目的 评价沙利度胺对糜烂型口腔扁平苔藓的疗效和不良反应.方法 选择本院口腔科门诊确诊的糜烂型口腔扁平苔藓70例,用随机数字表法分为两组,治疗组予沙利度胺100mg/d服用,对照组予雷公藤多苷60mg/d服用,治疗8周后比较两组患者的临床疗效和不良反应.结果 治疗8周后,治疗组有效率为94.12％,对照组为72.73％,两组差异有统计学意义(P＜0.05).治疗组和对照组不良反应发生率分别为8.57％和6.06％,两组差异无统计学意义(P＞0.05).结论 沙利度胺是治疗糜烂型口腔扁平苔藓的有效药物.

Objective To evaluate the clinical efficacy of an enhanced therapy after night guard vital bleaching to maintain a longer whitening effect .Methods Fifty pre-selected patients with discolored teeth were randomly and evenly divided into 2 groups .The treatment group received one enhanced therapy every month after night guard vital bleaching,a total of 12 times.The control group was treated with NGVB only .Vitalescence Esthetic Restorative Masters Shade Guide was used to record the change of color and help evaluate the lightening efficacy .Two groups were followed up for two years and the lightening efficacy was evaluated again by then .Results Two years later ,the treatment group's bleaching efficacy stayed the same as two years ago ,while that of control group dropped greatly .Conclusion The en-hanced therapy could greatly reduce the rebounce of discoloration .It is economical and practical ,easy to operate ,and is highly recommended to be used along with NGVB .

目的 分析白塞病的临床特征,减少临床医生的误诊率和漏诊率.方法 对2008年1月-2013年7月本院口腔科和皮肤科确诊的55例白塞病患者临床资料进行回顾性分析.结果 男∶女为1.29∶1;平均发病年龄(31.22±11.37)岁;平均病程(2.50±1.86)年.最常见的临床表现为口腔溃疡(98.18％),其次为生殖器溃疡(70.91％)、针刺反应阳性(69.09％)、发热(38.18％)、关节炎(36.36％)、结节性红斑(34.55％)、假性毛囊炎(30.91％)和眼损害(29.09％).实验室检查异常包括血沉增快(56.36％),白细胞计数升高(38.18％),IgG升高(36.36％),C反应蛋白升高(32.73％),中性粒细胞百分比升高(27.27％),IgM升高(20.00％).结论 白塞病的临床表现多样,可累及多器官和多系统,其实验室检查结果和组织病理学表现缺乏特异性,诊断主要依靠临床表现.

Ⅰ类清洁切口是指手术未进入炎症区,未进入呼吸、消化及泌尿生殖道,以及闭合性创伤手术符合上述条件者[1].一般的Ⅰ类清洁切口手术后大多无需使用抗菌药物.但实际上围手术期预防使用抗菌药物级别过高、疗程过长,一直是临床普遍存在的问题.为切实提高围手术期合理用药水平,我院在普外科设置专职临床药师进行了一系列药事干预,重点对Ⅰ类清洁切口手术抗菌药物预防用药进行全程干预,取得了不错的效果,现总结如下.

OBJECTIVE:To evaluate the clinical efficacy of a combined in-office cold light bleaching and night-guard vital bleaching (NGVB) system for treating tetracycline stained teeth (TST). METHODS:90 patients with light, medium and heavy TST were randomly and evenly divided into 3 groups. 30 patients with 472 TST from the treatment group were treated with in-office cold light bleaching and NGVB, 30 patients with 466 TST from the control group 1 were treated with in-office cold light bleaching and 30 patients with 469 TST from control group 2 were treated with NGVB. At the time of treatment completion, after half a year and after one year, Vitalescence esthetic restorative masters shade guide was used to record the change of color. Bleaching efficacy and course of treatment were calculated, and lightening stability were evaluated. RESULTS:1) Three groups had satisfied lightening efficacy for light TST with 100% bleaching efficacy. The overall efficacy of treatment group and control group 2 were superior to the in-office cold light bleaching system (P < 0.05). Though there was no significant lightening efficacy difference between the treatment group and control group 2 (P > 0.05), the periods of treatment of the treatment group for light, medium and heavy TST were shortened by 43%, 46% and 49%, respectively, compared to the control group 2. 2) All three groups' treatment efficacy for light, medium and heavy TST became weaker progressively (P < 0.05). 3) For the treatment efficacy between the time of treatment completion and after half a year and one year, there was significant statistical difference (P < 0.01) for the control group 1, while there was no significant difference for both the treatment group and the control group 2 (P > 0.05). Both treatment group and control group 2 had better performance in treatment stability than control group 1. CONCLUSION:In treating the light and medium tetracycline stained teeth, the combined in-office cold light bleaching and NGVB system can achieve a more satisfied whitening result in much shorter period, and significantly enhance the long term whitening stability.

Objective To evaluate the clinical efficacy of potassium nitrate gel to prevent nightguard vital bleaching sensitivity.Method 60 pre-selected patients with discolored teeth were randomly and evenly divided into 2 groups.The treatment group used potassium nitrate gel before and after each NGVB,while the control group was treated with NGVB only.Vitalescence Esthetic Restorative Masters Shade Guide was used to record the change of color and help evaluate the lightening efficacy.Results The control group has a higher incidence of light,medium and heavy sensitivity.66.6% of patients from the control group and 36.6% from the treatment group reported bleaching sensitivity,and there is a remarkable difference between the two groups(P0.01).Both groups have satisfied lightening efficacy for discolored teeth,and there is no significant difference between them(P0.05).However,the treatment group has a better grade improvement than the control group(P0.05).Both groups show that a higher degree of tooth sensitivity means a lower degree of shade enhancement.The treatment group's average grade(1.36) of sensitivity self evaluation is much lower than that(2.24) of the control group,and there is a significant difference between the two groups(P0.01).Patients of both groups with facial enamel fissures and gingival recession have a much higher incidence of sensitivity than those without(P0.01).Both groups' Loe-Silness gingival index and gingival recession assessment all showed satisfying periodontal safety.Conclusion Potassium nitrate gel will not affect NGVB'S bleaching efficacy,could effectively prevent the incidence of bleaching sensitivity,alleviate sensitivity discomfort,improve patient's feeling of comfort,help achieve a better lightening effect,and is highly recommended to be used along with NGVB.

目的:研究局部应用碱性成纤维生长因子(basic fibroblast growth factor,bFGF)治疗复发性口腔溃疡(RAU)的近期疗效.方法:80例RAU患者随机分两组,试验组溃疡面局部应用bFGF,对照组多贝尔氏液含漱,记录溃疡面愈合时间和疼痛缓解情况,进行统计学分析.结果: bFGF有促进溃疡面愈合,缓解疼痛的作用.结论:bFGF对RAU溃疡面的愈合有应用价值.