Early weaning from mechanical ventilation in children will lead to an extubation failure,however,prolonging mechanical ventilation will increase the risk of ventilator associated complication and the economical burden of disease.Nowadays there is no unified and objective ventilator weaning indexes in pediatrics,so it is significant to searching for appropriate and feasible ventilator weaning indexes.This article detailed the current progress on the condition and predictors of ventilator weaning in children,and comparing the predictability and accuracy of ventilator weaning indexes in children,also looking forward to the possibility of higher accuracy or scheme in ventilator weaning that used for clinical purposes.

微小RNAs(miRNAs)的异常表达与肿瘤的发生、分化、转移及复发等密切相关。研究发现,在食管癌组织中,miR-NAs在表达水平上明显区别于癌旁正常组织;在外周血中,miRNAs也表达出显著的肿瘤相关性、组织特异性和表达稳定性。本文将对miRNA作为食管癌血清标志物的研究进展作一综述。