Objective To observe the cognitive function and N400 performance in elderly patients with depression during remission. Methods 64 patients with senile depression who were admitted to our hospital from March 2017 to March 2018 were enrolled in the observation group. At the same time, 64 normal elderly people were convenient selected as the control group, and the simple intelligence status examination (MMSE), the Montreal Cognitive Assessment Form (MOCA) and the Daily Living Ability (ADL) Rating Scale are used to evaluate the cognitive function of all elderly people. At the same time, all N400 related events in the elderly were tested, and the potential N400 clinical value in the diagnosis of depression in the elderly was analyzed and summarized. Results The MMSE score of the observation group was (25.6±3.5) points, and that of the control group was (31.5±2.7) points (t=6.172, P=0.000). The MOCA score of the observation group was (22.3±4.8) points, which was significantly lower in the control group (29.3±2.4)points (t=5.196, P=0.000); the observation group ADL score was (22.4±3.1)points, which was significantly higher than the control group (16.4±1.5)points, which was different(t= 4.627, P=0.000); the matching and mismatch of Fz, Px, C3, C4 and N400 latency between the two groups were statistically significant (P＜0.05); The amplitudes matched by Fz, Px, C3, C4 and N400 were statistically significant (P＜0.05). Conclusion There is a certain cognitive dysfunction in elderly patients with depression, and the patient's own potential N400 also has abnormal conditions. The application of potential N400 in the diagnosis of remission depression in the elderly has obvious auxiliary value and is worthy of clinical promotion.

目的 观察草酸艾司西酞普兰联合奥氮平治疗老年抑郁症患者的安全性与有效性.方法 将医院收治的老年抑郁症患者78例作为研究对象,随机分为对照组和观察组,每组39例.对照组给予草酸艾司西酞普兰治疗,观察组给予草酸艾司西酞普兰+奥氮平治疗,比较2组临床疗效与不良反应情况.结果 观察组治疗总有效率为100.0％,高于对照组的79.5％(P<0.01);2组不良反应发生率比较差异无统计学意义(P>0.05).结论 草酸艾司西酞普兰联合奥氮平治疗老年抑郁症患者效果显著,可有效改善患者临床症状,不会增加不良反应发生率,安全、有效,值得临床推广应用.

ObJective:To explore the relationship between alexithymia and self-harmony in schizophreni-a. Method:This study adopted randomized controlled design. 62 patients with schizophrenia meeting the di-agnostic criteria of international classification of disease(the 10th edition)(ICD-10)were taken as research group. 70 healthy adults were taken as control group randomly. Assessments were conducted with the Toronto alexithymia scale(TAS-20)and self-consistency and congruence scale(SCCS)in the two groups. Results:On TAS,all the factor scores of research group were higher than the control group(P ﹤ 0. 05). In SCCS,re-search group showed higher scores on disharmony between self and experience and on self-stereotype( P ﹤0. 05)and lower score on self-flexibility(P ﹤ 0. 05)than the control group. Correlation analysis result indicated the factor lack of ability to identify emotion in AQC was positively correlated with disharmony between self and experience,self-stereotype of SCCS. Conclusion:Patients with schizophrenia demonstrate alexithymia and low self-harmony. Alexithymia is correlated with self-harmony.

Objective To explore the relationship between alexithymia and coping styles in schizophrenia. Methods This study adopted randomized controlled design. 62 patients with schizophrenia met the diagnostic criteria of the International Classification of Diseases,tenth edition(ICD - 10)were taken as research group. 70 health adults were taken as control group randomly. Assessments were conducted with the Toronto Alexithymia Scale(TAS - 20)and Coping Styles Questionnaire(CSQ)in the two groups. Results In the TAS,all the factor scores of research group were higher than the control group(P < 0. 05 or 0. 01). Compared the CSQ between the two groups,the factor scores of retreat,fantasy and self - accusation in research group were higher(P < 0. 01),the factor scores of rationalization and solve the problem were lower(P < 0. 01). In correlated analysis,factor P1 of TAS - 20 was positively correlated with fantasy,self - accusation and rationalization(r = 0. 352 ~ 0. 488,P < 0. 05)and negatively correlated with solve the problem of the CSQ(r = - 0. 327,P < 0. 05). Factor P2 was positively correlated with rationalization(r = 0. 256,P < 0. 05)and negatively correlated with solve the problem(r = - 0. 349,P < 0. 05). Conclusion The alexithymia and negative coping styles exist in schizophrenia. Alexithymia of schizophrenia is correlated with coping styles.

目的：探讨无抽搐电休克方法治疗难治性精神分裂症的临床疗效。方法选取38例难治性精神分裂症患者，在采用抗精神病药物治疗的基础之上行无抽搐电休克治疗，利用阳性与阴性症状量表(PANSS)、副反应量表(TESS)以及韦氏记忆量表(WMS)评定患者的疗效以及不良反应情况。结果临床联合行无抽搐电休克治疗后，PANSS量表评分明显低于治疗前（P<0.05），TESS评分后各时间段无明显差异P>0.05)，WMS评分在治疗第1d后明显低于治疗前（P<0.05），治疗后2 w与治疗前无明显差异(P>0.05)。结论临床行无抽搐电休克治疗难治性精神分裂症效果确切，不良反应率低，值得临床推广。

我们采用帕利哌酮治疗女性首发精神分裂症患者，探讨其对生活质量和执行功能的影响，现报告如下。

目的 探讨研究奥氮平对阿尔兹海默病精神行为症状的临床效果和安全性.方法 对2010年1月--2012年9月我院收治的阿尔兹海默病精神行为症状患者73例作为临床研究对象,使用单双号将患者随机分为两组,对照组给予利培酮治疗,实验组患者给予奥氮平治疗,对比观察两组患者治疗效果和患者治疗期间出现的不良反应.结果 实验组患者的总有效率为94.59%,对照组总有效率为91.67%,两组患者比较,以实验组的治疗效果更优,P<0.05,差异有统计学意义;两组患者的不良反应均较为轻微,且组间比较无显著差异,P>0.05,差异无统计学意义.结论 在治疗阿尔兹海默病伴有精神行为症状期间给予奥氮平治疗的效果更好,且不良反应少,值得应用.

Objective To observe the efficacy and side effects of Ziprasidone combined with sertraline in the treatment of negative symptoms in schizophrenia.Methods This study adopted simple randomized controlled design.Totally 82 inpatients met the diagnostic criteria of mental disorders of China were randomly assigned to Ziprasidone combined with sertraline group and Ziprasidone group.Each group had 41 inpatients for 8 weeks treatment.The max dosage of Ziprasidone was 160 mg/d in the two groups.The Positive and Negative Syndrome Scale(PANSS) and the Scale for the Assessment of Negative Symptoms(SANS) were used to evaluate the symptoms of the two groups before and after 2,4,8 week treatment.The Treatment Emergent Symptoms Scale(TESS) was used to evaluate the side effects of the two groups after 2,4,8 week treatment.Results The scores of PANSS,negative symptom and SANS in Ziprasidone combined with sertraline group were lower at 4,8 weekend.The scores of TESS in Ziprasidone combined with sertraline group was lower at 2,4,8 weekend.Conclusion Ziprasidone combined with Sertraline is effective and safe in the treatment of the negative symptom in schizophrenia.

Objective To explore the correlation between social support and parental rearing patterns of middle school students.Methods The research adopted systematic stratified sampling study.1115 middle school students from grade 1 to 3 of 4 middle schools in Yuxi city were assessed with the Egma minnen av bardndosnauppforstran(EMBU)and the Social Support Rating Scale(SSRS).Then the μ-test and Pearson correlation were analyzed.Results In EMBU,strict punishment,over interference,rejection and repudiation of father showed a difference between boys and girls(μ=4.047,2.338,2.301;P<0.05).In SSRS,the subjective support and utilization of social support showed differences between boys and girls(μ=2.544,4.087;P<0.05).In correlated analysis,all the factors of SSRS were positively correlated with emotional warmth and understanding of parents(r=0.3996,0.2743,0.3062,0.3770,0.2548,0.2775,P<0.05)and negatively correlated with strict punishment,rejection and repudiation of parents(r=-0.1927,-0.1092,0.1878,-0.1821,-0.0871,-0.1513,-0.2280,-0.0853,-0.1907,-0.2151,-0.0633,-0.1574;P<0.05).Conclusion Utilization of social support of middle school students can significantly promote individual psychological endurance and load-bearing capacity,increase the level of dealing with crises and conflicts;Parental rearing patterns on the effects of social support of children is very important.

Objective To explore the Alexithymia features of psychosomatic disorders and depression.Methods Assessments were conducted with the Hamilton Depression Scale(HAMD) and the Toronto Alexithymia Scale(TAS) to 62 psychosomatic disorders,66 depression and 60 healthy controls.Results The total score and factor scores of I,II and IV of TAS in psychosomatic disorders were higher than those of the control group(t1=4.230,P1=0.000);depressive patients showed higher scores in total score and all factor scores of TAS than the control group(t2=4.903,P2=0.000).The total score and factor scores of anxiety/somatization,cognitive disturbance and retardation of HAMA in psychosomatic disorders were higher than those of the control group(t1=0.365,P1=0.716);depressive patients showed higher scores in total score and factor scores of anxiety/somatization,cognitive disturbance,retardation,sleep disturbance and hopelessness of HAMD than the control group(t2=16.143,P2=0.000).Conclusion The four dimensions of Alexithymia play important roles in occurring and advancement of psychosomatic disorders and depression.The depression exists in the psychosomatic disorder.

目的 评价文拉法辛缓释剂(怡诺思)与氯丙咪嗪治疗老年抑郁症的临床疗效与安全性.方法 将60例老年抑郁症患者依住院顺序随机分为2组,分别给予怡诺思和氯丙咪嗪治疗,治疗前后用汉密尔顿抑郁量表(HAMD),不良反应量表(TESS)评定疗效和不良反应.结果 怡诺思与氯丙咪嗪治疗老年抑郁症的疗效相近,但前者起效更快,不良反应少于后者.结论 怡诺思治疗老年抑郁症是安全有效,依从性好,不良反应较少.

Objective To explore the relationship between the behaviors of mood disorder children and the education method of their parents.Methods To assess 82 children with mood disorder and 82 normal children with PLOC,PSQ and EMBU.Results The scores of the parents whose children had mood disorder were higher than the controls in educational effect,parents' responsibility,the parents' belief of fatal and pooprtunity and the parents' control of children's behaviors(P<0.05).There were some associations between factors of PLOC and the behaviors of mood disorder children.The parents whose children had mood disorder educated excessively,punished severely,interfered more often and gave more protections,but gave less understanding and supporting.Conclusion There was association between the behavior of mood disorder children and the parents' education mode.

Objective:To study the relationship among the psychological defensive mechanism,personal characters of teenagers with internet addiction and their parents' educational mode.Methods:The Internet Addiction Questionmire(IDQ),Defensive Style Questionmire(DSQ),Eysenk personality questionnaire(EPQ)and Egma Minnen av Bardndosnauppforstran(EMBU) scales were used to assess 75 Internet addictions and compared with 75 controls.Results:Firstly,the addictions adopted unripe and middle type of defensive mechanisms(χ2=4.23,P<0.05).Secondly,There were different levels of defects in the Internet addictive' personal characters.The last,There were obvious differences between the Internet addictive parents' educational mode and the control'.Conclusion:The first,the addictions adopted unripe defensive mechanisms more often,and had morbidity personal character,which had relativities obviously.The second,there was association between the Internet addictives and their parents' educational mode.

目的:研究丁二酸洛沙平对女性精神分裂症患者的疗效与不良反应.方法:将120例精神分裂症女性患者随机分成两组,研究组(洛沙平组)和对照组(维思通组),分别予丁二酸洛沙平和利培酮治疗8周,在治疗前及治疗后第2、4、6、8周分别进行PANSS量表和TESS量表评分.结果:两组之间疗效无显著差异.在阳性症状评分方面丁二酸洛沙平组和维思通组有显著性差异.研究组的主要不良反应为EPS、心动过速及植物神经不良反应,对照组主要为EPS、焦虑、失眠及泌乳.结论:丁二酸洛沙平是一种安全有效的抗精神病药物,在控制患者的阳性症状方面优于维思通,少数患者可出现锥体外系反应.

目的探讨乡村中小学教师心理健康状况.方法采用症状自评量表(SCL-90)对341名乡村中小学教师进行评定,同时与全国常模对照,小学教师与中学教师对照.结果乡村中小学教师SCL-90的总分、总均分、阳性项目数、躯体化、强迫、焦虑、敌对、恐怖、偏执、精神病性因子分均比常模高.小学教师除躯体化和其它因子分高于中学教师外,总分、总均分和其余各因子分与中学教师比较无差异.主要存在的心理问题是人际关系敏感、躯体化、强迫、其它等.结论乡村中小学教师存在心理健康问题,小学教师较中学教师严重.

本刊编辑部综合 编辑:本刊综合13篇关于精神药物副反应及其处理方面的稿件,其中有些副反应是颇为罕见,甚至未见报道的,可供临床参考.这些稿件是由14个单位29位作者所撰写的.