Objective To retrospectively analyze the effects of management techniques including systemic and topical therapeutic treatments for patients with toxic epidermal necrolysis(TEN). Methods The comprehensive therapy based on systemic treatments such as anti-shock, anti-infection, anti-allergic drug and primary disease treatment. Topical treatments for skin lesions included applications of acellular dermal sheet, nano silver dressing, artiifcial cellular healing membrane, growth factor, suspension bed, wound therapeutic apparatus and semi-conductive laser. Results Among these 22 patients, 19 patients were cured and discharged, 1 patient died from pulmonary embolism and 2 patients died from septic shock. Conclusions Systemic measures play key roles in maintaining stability of internal environment, which may control the progression of skin lesions and decrease the incidence of infection. Topical measures also play key roles in TEN treatment, e.g. relieving wound deepening by application of suspension bed, decreasing the incidence of wound infection by nano silver dressing, accelerating wound healing and reducing the pain of patients by application of acellular dermal sheet, artiifcial cellular healing membrane, growth factor and semi-conductive laser, etc.

烧伤患儿静脉补液及用药是其抢救和治疗的主要途径,特别是在患儿大面积烧伤休克期占有重要的地位.若静脉穿刺一次成功,可迅速建立静脉通道,不仅为烧伤的抢救和治疗提供了有效的保证,还为建立良好的护患关系打下基础.因此,熟练掌握小儿烧伤静脉穿刺技术非常必要.现将我科近年来提高小儿静脉穿刺成功率的经验和体会报告如下.

Objective:To explore the abnormal expression of cyclin D1 in keloid fibroblast,and the roles in mechanism of the keloid production pathogeny.Methods:The expression level of cyclin D1 in Keloid fibroblast(KFs)and normal skin fibroblast were taken from 4 respective cases and detected by cell immunohistochemistry and Western Blot.Results:The protein expression level of cyclin D1 in Keloid fibroblast was higher than that in normal skin fibroblast(P0.05);Western Blot results showed that the expression level of cyclin D1 was higher in the lab group than in the control group(P0.05).Conclusion:The abnormal expression of cyclin D1 in keloid fibroblast can play a role in keloid pathogenesis.

<正> 患者男,45岁,因雷管及电视机爆炸致全身多处部位爆炸伤并双眼失明、双耳失聋。先后在外院行多处部位爆炸伤清创缝合术,双眼裂伤缝合术,辗转1周来我院。糖尿病史2年,口服降糖药物治疗,伤后停用。入院查体:体温38.8℃,脉搏92次/min,呼吸24次/min,血压126/84 mm Hg

足部冻伤易发生在高纬度地区,常造成肌腱及骨坏死,在修复上具有一定难度,处理不当不仅影响外观,而且其足部正常功能还会因难以负重而受到影响,甚至被截肢,给患者工作和生活带来不便.2000年12月～2005年12月,我科应用腓肠神经营养血管筋膜皮瓣修复因足部冻伤引起的足跟部皮肤软组织缺损,取得良好效果,现报告如下.