目的 评价认知行为干预对晚期前列腺癌去势手术患者焦虑抑郁情绪及应对方式的影响.方法 选取2015年1月至2018年11月广州军区广州总医院诊治的42例晚期前列腺癌去势手术后合并焦虑抑郁情绪患者作为研究对象.按照随机数字表法将其随机分成试验组(n=21)和对照组(n=21).对照组按照相关诊疗标准进行药物治疗和常规护理;试验组在对照组基础上采用认知行为干预,每周3次.在干预前、术后第7天和术后第14天,用焦虑自评量表(SAS)和抑郁自评量表(SDS)分别评定两组患者的焦虑和抑郁情绪,用医学应对方式得分(MCMQ)评定两组患者应对行为.结果 术后7天和术后第14天,试验组患者的SAS和SDS评分均低于对照组,差异具有统计学意义(均P<0.05),试验组SAS及SDS评分不同时点间差异均具有统计学意义(均P<0.001);干预7天后,两组患者面对得分及回避得分组间差异均具有统计学意义(均P<0.05),而屈服得分在干预14天后差异具有统计学意义(P<0.001),试验组面对得分比对照组高,回避得分及屈服得分比对照组低,试验组面对得分、回避得分及屈服得分不同时点间差异均具有统计学意义(均P<0.001).随访治疗1年后的患者发现,试验组患者在认知功能、情绪功能、躯体功能、角色功能、社会功能、总体生活质量得分高于对照组,差异均具有统计学意义(均P<0.05).结论 认知行为干预能改善晚期前列腺癌去势手术后患者的焦虑抑郁负性情绪,改善应对方式,值得临床进一步推广.

Objective To observe the expression of microRNA-497 (miR-497) in bladder cancer cells and investigate its possible functions in epithelial-mesenchymal transition (EMT) of bladder cancer.Methods The expression of miR-497 in bladder cells and human normal bladder tissue were measured by real-time quantitative polymerase chain reaction (RT-qPCR).MiR-497 mimics and miR-497 inhibitor were transfected into bladder cancer EJ cells and RT-qPCR was used to analyze the effect of transfection.Then,morphological changes of cells were observed under the inverted microscope and the wound healing assay,transwell invasion assay were used to detect the cell migration and invasion of bladder cancer EJ cells transfected by miR-497 mimics and miR-497 inhibitor.cytometry.Finally,Western blotting was applied to detect the levels of EMT-related proteins.Results MiR-497 levels were obviously down-regulated in bladder cancer cells (5637,EJ,BIU-87,TCCSUP and T24) in comparison to human bladder pillon biochemical cell (SV-HUC-1),the difference was statistically significant (P =0.000).Compared with negative control,overexpression of miR-497 significantly suppressed EJ cells migration [(74.00 ± 3.61) ％ vs.(25.33 ± 6.11) ％] and invasion [(219 ± 17) cells vs.(109 ± 3) cells],and EJ ceils turned into epithelioid cells morphology,when compared with the control group.Moreover,opposite results were obtained when miR-497 inhibitor was transfected into EJ cells.Compared with mimics NC,the protein expression of E-cadherin was upregulated (P =0.000),while N-cadherin and vimentin downregulated (P =0.001,P =0.000) in miR-497 mimics transfection group.Conclusion MiR-497 may play an important role of EMT in bladder cancer.

Objective To compare clinical efficacy of intravesical instillation of epirubicin (EPI) and gemcitabine (GEM) for high-risk non-muscle invasive bladder cancer (NMIBC).Methods A total of 165 high-risk NMIBC patients in authors, hospital from July 2013 to April 2016 were retrospectively analyzed.All patients were randomly divided into auxiliary bladder perfusion chemotherapy EPI group (n=76) and GEM group (n=89) after implemented with transurethral resection of bladder tumor (TURBT).The tumor recurrence rate, time of recurrence, progression-free survival and adverse effects were evaluated.Results All patients were followed up, 3 cases in EPI group had severe perfusion side effects and stopped treatments, the tumor recurrence rate (24.72% vs.42.47%) of group GEM was significantly lower than that in group EPI (X2=5.738, P=0.017).There were no significantly different in tumor progression rates (12.36% vs.21.92%, X2=2.638, P=0.104) ,perfusion complications (X2=2.792, P=0.095) between groups GEM and EPI.Conclusion This study suggests that intravesical chemotherapy with EPI and GEM treatment can reduce tumor recurrence,but do not reduce tumor progress.GEM for preventing tumor recurrence curative effect is superior to EPI.

肾上腺嗜铬细胞瘤多为良性,该病典型表现为高儿茶酚胺症,引起以高血压、高血糖、高代谢等为主要表现的疾病,以持续高血压多见,由于其生物学行为不确定的特点,导致临床表现不确定和多变 [1] 。发病年龄以20~40岁青壮年居多,儿童少见,有家族遗传性。后腹腔镜下肾上腺嗜铬

临床护理工作中经常会遇到迁床的工作,但在迁床过程中容易出现丢三落四的现象,这样不仅给工作带来安全隐患,也容易导致医疗护理差错事故的发生,为此,我科自行设计了一种迁床流程表,效果很好.

注射用夫西地酸钠为白色块状物或粉末,适用于各种敏感细菌引起的感染,尤其是葡萄球菌引起的感染,如肺炎、败血症、皮肤软组织感染等.悉复欢属于第三代喹诺酮类药物,化学名:乳酸环丙沙星氯化钠注射液,适用于对本品敏感