Objective:To investigate the expression and clinical significance of Jagged1 and Budding uninhibited by benzimidazoles-1 (BUB1) in non-small cell lung cancer (NSCLC).Methods:A total of 108 cases of NSCLC tissues and non-cancerous adjacent lung tissues from Affiliated Hospital of Guangdong Medical University with complete clinicopathological and medical records from August 2018 to May 2022 were collected. The expression levels of Jagged1 and BUB1 in the above tissues were detected by immunohistochemistry, and Chi-square test was used for statistical analysis. The relationship between Jagged1 and BUB1 expression and clinicopathological parameters of NSCLC was analyzed.Results:The positive expression rate of Jagged1 in cancer tissues of NSCLC patients was 81.48% (88/108), and the positive expression rate of Jagged1 in the non-cancerous adjacent lung tissues was 21.30% (23/108) with the difference being statistically significant ( χ2=78.301, P<0.01). The expression level of Jagged1 was significantly correlated with histological differentiation, lymph node metastasis and TNM stage of NSCLC (respectively, χ2=8.062, 5.268, 4.477, P<0.05), but not with gender and age of NSCLC (respectively, χ2=0.238, 0.008, P>0.05). The positive expression rate of BUB1 in cancer tissues of NSCLC patients was 75.00% (81/108), and the positive expression rate of BUB1 in adjacent tissues was 33.33% (36/108) with the difference being statistically significant ( χ2=37.762, P<0.01). The expression level of BUB1 was significantly correlated with lymph node metastasis and TNM stage of NSCLC (respectively, χ2=4.945, 6.008, P<0.05), but not significantly with age, histological differentiation and gender of NSCLC (respectively, χ2=0.013, 0.012, 0.234, P>0.05). Conclusion:Jagged1 and BUB1 are highly expressed in the cancer tissues of NSCLC patients, the abnormally elevated expression levels of Jagged1 and BUB1 are related to the malignant degree and poor prognosis of NSCLC, and are involved in the occurrence and development of NSCLC to a certain extent, which can be used as candidate targets for the diagnosis and treatment of NSCLC.

目的 比较EuroSCOREⅡ和阜外瓣膜手术风险评分在心脏瓣膜置换术后预后评估中的效用.方法 回顾分析2013年1月-2017年12月在本院行心脏瓣膜置换手术的376例患者的临床资料,分别使用EuroSCOREⅡ和阜外瓣膜手术风险评分对患者术后预后进行风险评分,评价两种评分系统对心脏瓣膜术后发生死亡及主要并发症的预测效能,采用患者特征曲线下面积(AUC)评价两种模型的区分能力,采用Hosmer-Lemeshow拟合优度检验评价其校正能力.结果 共376例患者施行了瓣膜置换术,共10例患者死亡,实际死亡率2.66％,EuroSCOREⅡ评分和阜外瓣膜手术风险评分预测死亡率分别为(3.5±6.8)％和(3.6±4.2)％;ROC曲线下面积分别为0.872和0.674;Hosmer-Lemeshow检验的P值分别为0.354和0.012;在预测术后主要并发症方面,EuroSCOREⅡ对术后肾功能不全、低心排综合征、机械通气时间长的区分度较好,而阜外瓣膜手术风险评分术后总并发症、术后低心排综合征、术后机械通气时间延长、重症肺炎发生率的区分度较好.结论 两种评分系统对本地区心脏瓣膜置换术后主要并发症的风险预测均有较好的应用价值.

Objective To investigate the clinical effect of selective bronchial artery infusion chemotherapy for central squamous cell carcinoma of the lung.Methods 93 cases of central lung squamous cell carcinoma patients who were treated in our hospital from February 2015 to February 2017 were enrolled in the study.They were divided into the observation group (n =45) and the control group (n =48) according to the patients'final treatment.The observation group was treated with bronchial artery perfusion chemotherapy,and the control group was treated with systemic venous chemotherapy.The short-term effect and the improvement of lung function in the two groups were observed,and the prognosis of the patients was followed up.Results The short-term effect of the observation group was better than that of the control group (P ＜0.05),and the total effective rate of the observation group was 95.56％;The forced vital capacity (FVC)and forced expiratory volume in the first second (FEV,) of the observation group were (75.39 ± 6.88)％and (78.19 ± 7.79)％,respectively,which were significantly higher than those in the control group (P ＜0.05).The reoperation ratio of the observation group was 44.44％ after chemotherapy,which was significantly higher than that of the control group,with statistically significant difference (P ＜ 0.05).The median total survival time of the observation group was 17 months,which was significantly higher than that of the control group,with statistically significant difference (P ＜ 0.05).The incidence of adverse reaction in the observation group was 6.67％,which was significantly lower than that in the control group,with statistically significant difference (P ＜ 0.05).Conclusions Selective bronchial artery infusion chemotherapy for central lung cancer is effective and worthy of clinical application.

目的 探讨下肺叶切除术后应用腹带以促进患者快速康复的可行性.方法 2015年3月至2016年5月在本院行下肺叶切除术的患者50例,随机分为两组,观察组26例,对照组24例.对照组术后接受加强呼吸功能锻炼、保持引流管通畅等传统方法治疗,观察组加用腹带束腹,余治疗措施相同.比较两组患者术后胸腔积液引流量、拔胸管时间等,观察两组术后胸内残腔情况.结果 观察组术后胸腔积液引流量、拔管时间均明显小于对照组(P<0.05).结论 下肺叶切除术后应用腹带可减少胸腔积液,缩短拔管时间而有助于术后快速康复.

Objective To investigate the expression of B7-H4 and cell division cycle 42(Cdc42)in non-small cell lung carcinoma(NSCLC),and their relation to the clinicopathological features.Methods Envision immunohistochemical method were used to assess the expression of B7-H4 and Cdc42 in 92 cases of human NSCLC tissues and non-cancerous adjacent lung tissues.Results The expression rate of B7-H4 in breast carcinoma tissues was higher than that of non-cancerous adjacent breast tissues(44.57％vs.8.70％,P＜0.01),the expressions of B7-H4 were related NSCLC to TNM stage and lymph node metastasis(P＜0.05);the expression rate of Cdc42 in breast carcinoma tissues was higher than that of non-cancerous adjacent breast tissues(56.52％vs.4.35％,P＜0.01);there was a close relation between the expression of Cdc42 and histology grade,histology grade and TNM stage(P＜0.05).Conclusion B7-H4 and Cdc42 may be participate in the development and progression of NSCLC.

<正>患者男,3岁5个月。以"反复咳嗽、胸痛2个月,加重伴呕吐6 d"入院。查体:体温36.8℃,脉搏102次分,呼吸频率39次/分,体重17 kg。神志清醒,精神欠佳,呼吸急促,无明显面色苍白、鼻翼扇动及口唇紫绀,咽部充血,口腔少量粘液。颈软,气管居中。