Objective:To investigate the effect of life review therapy on spiritual comfort and dignity among patients with advanced bladder cancer, to provide reference for the improvement of quality of death outcomes.Methods:A total of 60 patients with advanced bladder cancer who were admitted to the Cancer Hospital of the University of Chinese Academy of Sciences from March 2018 to January 2020 were selected as the research objects. Randomly divided all the patients into the control group and the experimental group, 30 cases in each group. The control group was given routine end-of-life care, and the experimental group was given 5 times of life review therapy on the basis of the control group. The effect of the intervention was evaluated by the Functional Assessment of Chronic Illness Therapy-Spiritual Well-being Scale(FACIT-Sp-12) and the Patient Dignity Inventory (PDI).Results:Finally, there were 28 cases in the experimental group and 29 cases in the control group. After the intervention, the scores of peace, meaning and belief demensions and total scores in FACIT-Sp-12 in the experimental group were (10.61 ± 2.23), (11.14 ± 1.90), (10.67 ± 1.79) and (32.36 ± 3.28), respectively, which was significantly higher than those in the control group (8.34 ± 2.24), (10.03 ± 1.49), (8.66 ± 1.89) and (27.03 ± 3.61), the differences were statistically significant ( t values were 2.45-5.82, all P<0.05). The psychological state, dependence, mental peace, social support demension scores and total scores of PDI in the experimental group were (8.64 ± 2.06), (3.14 ± 0.89), (4.21 ± 0.79), (2.43 ± 0.69) and (28.46 ± 4.98), which were significantly lower than those in the control group (10.34 ± 2.93), (4.17 ± 1.17), (4.93 ± 1.33), (3.17 ± 1.07) and (34.01 ± 4.79), the differences were statistically significant ( t values were 2.48-4.28, all P<0.05). Conclusions:Life review therapy can promote spiritual comfort and alleviate dignity destroyed in patients with advanced bladder cancer.

目的 探讨预见性护理干预对前列腺癌根治术患者术后尿失禁的影响.方法 选取2020年1月至2021年10月于中国科学院大学附属肿瘤医院确诊的前列腺癌并接受前列腺根治术的80例患者纳入本研究.根据纳入时间先后将其分为对照组(2020年1～12月,40例)和研究组(2021年1～10月,40例).对照组患者给予前列腺癌根治术后常规护理,研究组患者应用基于循证护理的前列腺癌根治术后尿失禁的预见性护理.比较两组患者的国际尿失禁咨询委员会尿失禁问卷(international consultation on incontinence questionnaires,ICIQ)评分、尿垫使用情况及对护理的满意度.结果 术后6个月,两组患者的ICIQ评分均显著低于本组术后3个月(P<0.05);术后3个月、6个月,研究组患者的ICIQ评分均显著低于同期对照组(P<0.05).两组患者的尿垫使用情况比较差异无统计学意义(P>0.05).研究组患者的总满意度显著高于对照组(χ2=11.259,P=0.010).结论 基于循证护理的预见性护理干预能更有效地预防前列腺癌根治术后尿失禁的发生,改善患者的生活质量,提高患者的满意度.

Background: Kidney carcinoma is a major cause of carcinoma-related death, with the prognosis for advanced or metastatic renal cell carcinoma still very poor. The aim of this study was to investigate feasible prognostic biomarkers that can be used to construct a prognostic index model for clear cell renal cell carcinoma (ccRCC) patients. Methods: The mRNA expression profiles of ccRCC samples were downloaded from the The Cancer Genome Atlas (TCGA) dataset and the correlation of AIF1L with malignancy, tumor stage and prognosis were evaluated. Differentially expressed genes (DEGs) between AIF1L-low and AIF1L-high expression groups were selected. Those with prognostic value as determined by univariate and multivariate Cox regression analysis were then used to construct a prognostic index model capable of predicting the outcome of ccRCC patients. Results: The expression level of AIF1L was lower in ccRCC samples than in normal kidney samples. AIF1L expression showed an inverse correlation with tumor stage and a positive association with better prognosis. ccRCC samples were divided into high- and low-expression groups according to the median value of AIF1L expression. In the AIF1L-high expression group, 165 up-regulated DEGs and 601 down-regulated DEGs were identified. Three genes (AIF1L, SERPINC1 and CES1) were selected following univariate and multivariate Cox regression analysis. The hazard ratio (HR) and 95% confidence intervals (CI) for these genes were: AIF1L (HR = 0.83, 95% CI: 0.76–0.91), SERPINC1 (HR = 1.33, 95% CI: 1.12–1.58), and CES1 (HR = 0.87, 95% CI: 0.78–0.97). A prognostic index model based on the expression level of the three genes showed good performance in predicting ccRCC patient outcome, with an area under the ROC curve (AUC) of 0.671. Conclusion: This research provides a better understanding of the correlation between AIF1L expression and ccRCC. We propose a novel prognostic index model comprising AIF1L, SERPINC1 and CES1 expression that may assist physicians in determining the prognosis of ccRCC patients.

目的 研究阴茎癌患者术后的病耻感现状.方法 使用社会影响量表对本院2011年至2017年行阴茎癌切除手术的60例患者的病耻感进行调查,并对相关原因进行分析.结果 本组60例患者在阴茎癌手术后均存在不同程度的病耻感.结论 病耻感会使患者感到沮丧和自卑,社交能力下降,极大地影响了患者的生活质量,这已经成为了一个不容忽视的问题,亟需采取相关措施降低阴茎癌术后患者的病耻感.