Objective: Design a feasible study to assess the efficacy and safety of Craniosacral therapy (CST) in the treatment of migraine, using a rigorous and innovative randomized controlled study design involving complementary light-touch sham treatments (CLST) as an attention control intervention. Methods: This was a single-center, randomized, cross-over placebo-controlled experimental design. A total of 87 participants who suffered migraine attacks from 4 to 9 per month were randomly assigned into either 2 weekly units of CST or CLST for 4 weeks. And then the 2 groups were crossed and continued treatment for 4 weeks plus a follow-up observation for 4 weeks. As the primary outcome measures, Headache Impact Test-6 (HIT-6) and headache frequency were assessed every 4 weeks (at baseline, week 4, week 8 and week 12). The secondary outcome was the scores of Headache Disability inventory (HDI) and the Hamilton Anxiety Scale (HAMA) as well as the adverse events. Results: All 87 individuals had been screened for eligibility, of which 60 were licensed for the study. The difference of HIT-6 and headache frequency between the 2 groups was not significant at the baseline. But the headache frequency and HIT-6 of 2 groups were all declined respectively after the CST at week 4 (group A) and week 8 (group B) than before (P ☆= 0.01 < 0.05, 95% CI, −3.06 to −1.87; P ※= 0.01 < 0.05, 95% CI, −3.52 to −2.53; P 1A = 0.01 < 0.05, 95% CI, 4.55–11.7; P 2B = 0.01 < 0.05, 95% CI, −11.78 to −6.01) while the changes were not obvious after CLST with previous treatment. The scores and frequency of fourth evaluation showed that there was no significant increase or decrease in both the 2 groups. Besides, we found that the mean scores of HIT-6 for all participants, compared with the baseline, were decreased significantly after the 3 round treatments (P 3A = 0.01 < 0.05, 95% CI, −13.12 to −6.4; P 3B = 0.01 < 0.05, CI, −12.73 to −6.69). We also showed the similar result in the scores of HDI and HAMA. Conclusion: The results indicated that standardized CST was both effective and safe in alleviating the migraine intensity and frequency as well as the headache-related disability. Further larger research is needed.

目的:探究2型糖尿病周围神经病变患者运用步行阶梯训练的效果。方法:选取黄河水利委员会黄河中心医院收治的116例2型糖尿病周围神经病变患者，根据数字表法随机分组。对照组58例给予常规有氧运动训练，观察组58例增加步行阶梯训练，两组均持续干预6个月，对比疗效。结果:干预后，观察组足底压力中心轨迹(COP)曲线异常率、全足压力变化曲线异常率、全足平衡性曲线异常率、计时-起立测试(TUGT)、跌倒指数(FI)低于对照组，差异具有统计学意义( P<0.05)。干预后，观察组睁眼单腿站立测试(OLST)、闭眼OLST均高于对照组，差异具有统计学意义( P<0.05)。 结论:有氧运动与步行阶梯训练改善神经传导速度效果相当，但步行阶梯训练联合有氧运动改善2型糖尿病周围神经病变患者的动态平衡功能、步态调控效果更佳。

目的:探讨高频重复经颅磁刺激联合吞咽康复训练对脑卒中后吞咽障碍的治疗效果.方法:选取2017年1月—2019年12月在黄河水利委员会黄河中心医院接受康复治疗的脑卒中后吞咽困难患者160例为研究对象.采用随机数字表法分为单纯吞咽康复训练组80例和高频重复磁刺激+吞咽康复训练组80例.比较两组患者治疗后神经损伤情况、神经营养指标以及治疗效果.结果:神经损伤指标上,干预组治疗后VILIP-1、NSE、Fibulin-5和NPY较对照组低(P<0.05).神经营养指标上,干预组治疗后IGF-1、BDNF、NGF、VEGF较对照组高(P<0.05),Nogo-A较对照组低(P<0.05).治疗后吞咽时程、PAS评分和SSA评分较对照组低(P<0.05),吞咽最大振幅、VFSS评分较对照组高(P<0.05).结论:高频重复经颅磁刺激联合吞咽康复训练能够有效促进脑卒中后吞咽障碍患者的神经功能恢复及提升神经营养指标,进一步提高治疗的效果和减少吞咽障碍对患者生活质量的影响,值得在临床应用与推广.

目的 探讨针灸结合颅骶疗法对颞下颌关节紊乱病患者下颌功能及疼痛程度的影响.方法 60例颞下颌关节紊乱病患者根据治疗方法的不同分为对照组(n=28)与观察组(n=32).在常规保守治疗的基础上,对照组予以针灸治疗,观察组予以针灸结合颅骶疗法治疗.比较两组的临床疗效,以及治疗前后的下颌功能及疼痛程度.结果 观察组的治疗总有效率为93.75％,显著高于对照组的72.43％(P＜0.05).治疗后,观察组的MFIQ评分、VAS评分均显著低于对照组(P＜0.05).结论 针灸结合颅骶疗法治疗颞下颌关节紊乱病患者疗效显著,可有效减轻疼痛程度,改善下颌功能.

Objective:To study the effect of craniosacral therapy on neuron discharge and sleep quality in patients with migraine.Methods:60 patients with migraine who admitted in our hospital from September, 2018 to September, 2019 were divided into a control group and an observation group according to random number table, with 30 cases in each group. The control group was treated with scalp acupuncture; in addition, the observation group was given craniosacral therapy. The symptom indicators, cerebrovascular blood flow, and improvement of sleep quality were compared between two groups before and 4 weeks after the treatment.Results:Before the treatment, there were no statistical differences in the frequency, duration, and VAS score of headache between the two groups (all P>0.05). After the treatment, the frequency, duration, and VAS score of headache were (1.46±0.94) times/month, (3.24±1.16) min per time, and (0.54±0.15) in the observation group, which were lower than those in the control group ( P<0.05). Before the treatment, there were no statistical differences in the scores of VA, BA, ACA, MCA, and sleep quality between the two groups (all P>0.05). After the treatment, the scores of VA, BA, ACA, MCA, and sleep quality were( 85.93±14.76) m/s, (51.03±8.07) m/s, (65.24±13.67) m/s, (86.68±17.11) m/s, and (53.02±6.03) in the observation group, which were significantly higher than those in the control group (all P<0.05). Conclusion:Craniosacral therapy for patients with migraine can relieve their degree of pain, improve their sleep quality and cerebrovascular blood flow, and reduce frequency of headache, and has more significant curative effect.

目的 从整合医学角度出发,以个体化治疗为基础,探讨慢性便秘综合诊治团队对慢性便秘的干预治疗作用,为慢性便秘的治疗提供新思路.方法 选择2013年4月-2014年4月在本院就诊的慢性便秘患者120例,随机分为对照组和干预组各60例,对照组实施患者自主就诊,给予泻药的治疗模式管理半年;干预组进行个体化综合干预治疗,除给予泻药外,辅助以饮食改变、心理指导、运动锻炼、康复指导等干预方式,并随访强化管理,以该模式管理半年.结果 2组患者治疗效果比较,差异有统计学意义(P＜0.05).经3～6个月综合治疗后干预组患者每周排便次数较对照组提高明显,在大便性状评分和排便困难程度评分方面均较对照组明显改善(P＜0.05).结论 慢性便秘综合诊治团队能针对每个患者制定长期的个体化方案,提高诊治效率和疗效.

目的：探讨导管球囊扩张术对环咽肌失弛缓症所致吞咽障碍的治疗疗效以及其疗效是否与时间效应有关。方法选取2013年5月～2015年5月我院神经康复科收治的由脑卒中后引起环咽肌失弛缓所致吞咽障碍患者20例作为研究对象，将其随机分为治疗组和对照组，各10例。治疗组给予导管球囊扩张术，辅助以常规吞咽康复治疗，对照组只给予常规康复治疗，共6周，每周6次训练，分别在治疗前、治疗3周和治疗6周时对每一个患者采用洼田饮水试验和视频吞咽造影（VFSS）检查两种方法进行吞咽功能评定。结果治疗组患者吞咽功能较对照组有明显改善，差异有统计学意义（P＜0.05）；两组患者吞咽功能治疗后不同时间点均较治疗前有改善，差异有统计学意义（P＜0.05）。结论导管球囊扩张术对吞咽障碍的疗效显著，且与时间相关联。