目的 分析和探讨生化检验指标在糖尿病诊断中的价值.方法 以2017年9月至2019年9月为时间基准,在我院所有糖尿病患者当中,随机收集33例作为观察组,同期选取33名健康体检者作为对照组,对两组研究人员均进行生化检验.对比两组生化检验的结果 .结果 观察组的LDL-C、TG、TC、GLU、FRUC均高于对照组,HDL-C低于对照组;观察组空腹血糖水平、餐后2h血糖水平以及HbAlc均高于对照组(p值<0.05).结论 生化检验指标在糖尿病诊断中的价值显著,能够作为评估和判断糖尿病的依据和参考,适合在临床进行实施和开展.

目的 通过基于精准护理理念干预方案的实施,探讨其对妊娠糖尿病(GDM)患者血糖控制、分娩方式及围生儿结局的影响.方法 选取2019年6月至2020年10月在新乡医学院第一附属医院就诊的120例GDM患者,采用随机数表法将患者分为对照组和研究组,每组60例.对照组接受常规护理及健康宣教;研究组接受精准化护理策略.比较两组患者实施不同护理方式后血糖水平,统计两组患者分娩方式及围生儿结局.结果 护理前两组患者血糖水平比较,差异无统计学意义(P>0.05).护理后,两组患者空腹血糖(FPG)、餐后2小时血糖(2 h PG)水平均低于护理前,差异有统计学意义(P<0.05);研究组FPG、2 h PG水平低于对照组(P<0.05);研究组分娩方式、围生儿结局均优于对照组,差异有统计学意义(P<0.05).结论 通过对GDM患者实施基于精准护理理念的干预方案,可有效控制其血糖水平,降低剖宫产率、巨大儿发生率及新生儿低血糖发生率,改善妊娠结局,促进母婴健康.

We firstly investigated the association between IL-18 -137G/C and -607C/A genetic polymorphisms and the risk of developing diabetic nephropathy in a Chinese Han population. A total of 155 patients diagnosed with type 2 diabetes mellitus and 320 healthy controls were recruited from the First Affiliated Hospital of Xinxiang Medical University between January 2013 and March 2015. Genotyping of IL-18 -137G/C and -607C/A polymorphism was performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). As determined by multiple logistic regression analysis, individuals carrying GC genotype of IL-18 -137G/C were correlated with an elevated risk of diabetic nephropathy in comparison with the GG genotype, and the crude and adjusted ORs were 2.31 (1.49-3.56) and 2.54 (1.63-4.11), respectively. Moreover, the C allele of IL-18 -137G/C was associated with risk of developing diabetic nephropathy in comparison with G allele, and the crude and adjusted ORs were 1.81 (1.25-2.59) and 2.16 (1.36-2.85), respectively. In conclusion, our study suggests that IL-18 -137G/C is associated with development of diabetic nephropathy in the Chinese population.

Type 2 diabetes mellitus, a chronic and complex disease. NLRP3 inflammasome plays an important role in the obesity induced inflammation and insulin resistance, and polymorphisms of NLRP3 may contribute to the development of type 2 diabetes mellitus. Here, we carried out a study to investigate the role of two SNPs of NLRP3 (rs10754558 and rs4612666) in the risk of type 2 diabetes mellitus in a Chinese population. This study comprised of 286 patients with type 2 diabetes mellitus and 306 healthy control subjects. Genotyping of NLRP3 rs10754558 and rs4612666 was done using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Using unconditional logistic regression analysis, we observed that homozygous NLRP3 rs10754558 CC carriers demonstrated a significantly higher risk of developing type 2 diabetes mellitus in comparison to homozygous GG carriers, with an adjusted OR (95% CI) of 2.38 (1.53-3.97). Moreover, the C allele of NLRP3 rs10754558 was associated with an elevated risk of NLRP3 rs4612666 when compared to G allele (OR = 1.51, 95% CI = 1.18-1.91). However, we observed no significant relationship between NLRP3 rs4612666 genetic polymorphisms and type 2 diabetes mellitus risk in the Chinese population. In summary, our study has shown that the polymorphism of NLRP3 rs10754558 is associated with high risk of type 2 diabetes mellitus.

[目的]调查1型糖尿病病人主要照顾者负担的现状及其影响因素，为相关心理护理、行为干预提供科学依据。[方法]采用便利抽样法，选择94例1型糖尿病病人主要照顾者进行问卷调查，问卷包括自制一般资料问卷、照顾者负担量表、社会支持评定量表。[结果]本组调查对象照顾者负担总分为(31.49±13.65)分，处于轻度负担水平。主观支持、身体劳累、自觉身体状况、经济困难是照顾者负担的主要预测因素。[结论]1型糖尿病病人主要照顾者普遍存在照顾负担，应采取针对性的护理措施，减轻其身心负担，帮助其更有效地辅助照顾病人，优化疾病控制情况。

目的：探讨老年患者行玻璃体切割术的和硅油填充术健康教育。方法：对58例老年患者行玻璃体切割术硅油填充术健康教育进行分析总结。结果：58例老年患者经过护理人员对他们进行术前，术中、术后健康教育，出院的回访，患者无出现严重的并发症视力有不同程度提高。结论：术前充分准备、术中的配合，尤其术后体位的健康教育，出院的回访是对玻璃体切割和硅油填充术尤为重要。

One of the most important molecules mediating the proliferation, growth, and metastasis of cancer cells is insulin-like growth factor (IGF), with its receptor IGF-1R. Here, we describe the potential of an IGF-1R monoclonal antibody, HX-1162, on liver cancer apoptosis in vitro and in vivo. We found that HX-1162 could induce the apoptosis of cultured liver cancer cells. Additionally, HX-1162 treatment inhibited the tumor growth after cancer cell grafting and enhanced the cell apoptosis inside the tumor tissue. We conclude that IGF-1R targeting therapy provides a new avenue toward treating liver cancer.

【Objective】To summarize the effects and experiences of the implementation of quality nursing in patients with pituitary tumor.Method:Quality nursing services,including health education after admission,preoperative and postoperative nursing care,and rehabilitation guidance at discharge were implemented in the pituitary tumor patients.Results:The degree of satisfaction with quality nursing from the patients improved significantly.It shortened the hospitalization time,reduced the cost of hospitalization.Conclusion:Through the implementation of the quality nursing,the nurse-patient relationship is improved and the nurses'own value in nursing work as well.

目的:比较普通一次性注射器与一次性胰岛素注射器在注射剂量、准确性及精密度方面的差异。方法:采用对照研究。分别在注射剂量4、10、20IU时,对普通1mL一次性注射器与1mL(40IU,40IU/mL)一次性胰岛素注射器的实际剂量、准确性及精密度进行比较。采用称重法对实际注射剂量进行检测。注射剂量用均数±标准差表示,准确性用相对离差绝对值来表示,用变异系数来评价精密度。所有注射均由专业护理人员完成。结果:一次性胰岛素注射器与普通一次性注射器比较,目标剂量为4IU时,实际注射剂量为(4.03±0.26)IUvs(3.76±0.44)IU,P=0.0065;相对离差绝对值为(5.58±3.16)%vs(10.43±6.88)%,P=0.0013;变异系数为6.41%vs11.74%,P<0.01。目标剂量为10IU时,实际注射剂量为(10.06±0.24)IUvs(9.92±0.42)IU,P=0.110;相对离差绝对值为(1.98±1.49)%vs(3.88±1.99)%,P=0.000;变异系数分别为2.41%vs4.26%,P<0.01。目标剂量为20IU时,实际注射剂量为(20.11±0.47)IUvs(19.98±0.40)IU,P=0.338;相对离差绝对值为(1.89±1.46)%vs(2.33±1.92)%,P=0.396;变异系数分别为2.33%vs2.97%,P>0.05。结论:目标剂量为10IU以下时,一次性胰岛素注射器的准确性与精密度优于普通一次性注射器,超过10IU时两种注射器的准确性与精密度趋于接近。

目的:探讨强化护理操作考核对临床护理工作的影响.方法:对全院各级护理人员连绪两年加强考核,将考核成绩与护理差错、患者满意度加以对比.结果:临床护理质量明显提高,减少了护理纠纷,确保护理安全,患者满意度明显提高,充分体现了人文关怀.结论:随着医学模式的转变、护理学的发展和社会文明程度的提高,护士人性化服务的重要性日益彰显,加强护理操作考核,是提高护理技术的有力保障.

目的:探讨系统化模式教育对糖尿病抑郁患者的影响。方法:门诊糖尿病患者45例,采用我国正常成人抑郁自评量表(SDS)标准自评,达抑郁标准者入组。采用多媒体以讲座形式,集中教育糖尿病相关系列知识。结果:99%患者抑郁情绪得到了改善。结论:在糖尿病抑郁患者逐年增高的趋势中,使患者掌握系统糖尿病治疗的基本措施,提高自我管理能力,对改善患者负性情绪具有重要意义。

目的:通过对需要用胰岛素治疗的老年患者的健康教育及正规治疗,提高患者的住院适应能力和自我保健能力,从而提高患者的生活质量。方法:对住院患者2004~2006年我院就诊的老年患者320例,进行合适的健康教育。结果:97%的患者都能坚持正规应用胰岛素治疗,减少了并发症的发生,使患者医疗费用明显降低、住院日明显缩短,同时提高了患者治疗依从性。结论:糖尿病的治疗为一种综合治疗,注射胰岛素是药物治疗中重要的措施之一,教会患者及家属正规注射胰岛素,是糖尿病治疗的重要保证,加强对患者及家属的健康教育具有一定的临床意义。

Objective To explore the effects of psychotherapy on depression with type Ⅱ diabetes patients and to explore its qulity of life. Methods 86 patients with type Ⅱ diabetes disease accompanied patients were divided into psychotherapy and nonpsychotherapy groups. The scores of SDS, SF-36 quality of life questionnaire and clinical outcome were evaluated between the two groups. Results The scores of SDS of the Psychotherapy group were significantly lower than the control group, The evaluation of clinical outcome were singficantly better than the control group (P<0.05 or P<0.01). While the SF-36 quality of life questionnaire scores with Psychotherapy group were singficantly better than the control group besides physiological function (P<0.05 or P<0.01). Conclusion Psychotherapy could obviously decrease the degree of depression and improves clinical outcome, physical function and quality of life in patients with type Ⅱ diabetes disease.

胰岛素泵模拟人体胰腺,每数分钟就自动释放微量短效胰岛素,使血糖在餐间及夜间睡眠期间保持平稳.进餐时,通过设置泵的程序(按动泵上按钮)使泵迅速输出较大剂量胰岛素,它能对付食物中所含碳水化合物量,因而能有效降低餐后高血糖状态.

对我院老年糖尿病便秘的护理总结如下. 1 临床资料 1.1 一般资料 2004-10～2006-06在我院住院老年糖尿病患者40例,年龄60～85岁,均符合1998年WHO糖尿病诊断标准,糖尿病病史8～33 a,住院时间平均15 d,3～10 d内无大便,有3个月～2 a的便秘史.其中糖尿病肾病7例,糖尿病足5例,糖尿病足致截肢3例,糖尿病合并脑梗死15例,糖尿病并腰椎骨折1例,糖尿病合并胃肠神经病变9例.