Objective:To investigate the effects of C-X-C motif chemokine ligand 5(CXCL5)and C-X-C motif chemokine receptor 2(CXCR2)levels in tumor tissue of esophageal cancer patients on the condition and prognosis of esophageal cancer, and to provide a new direction for clinical diagnosis, treatment and prognosis evaluation of esophageal cancer.Methods:A total of 126 patients with esophageal cancer without radiotherapy and chemotherapy who were diagnosed at the Affiliated Hospital of Xuzhou Medical University from August 2013 to July 2015 and had complete clinical data were selected as the research objects.The expression levels of CXCL5 and CXCR2 in esophageal cancer tissues were detected by immunohistochemical staining, and the relationships between the expression levels of CXCL5 and CXCR2 and the clinicopathological classification and survival prognosis of esophageal cancer were explored.Results:The positive expression rates of CXCL5 and CXCR2 in esophageal cancer tissues were significantly higher than those in adjacent tissues(P<0.05), and there was a correlation between the two(P<0.05). CXCL5 and CXCR2 in esophageal cancer tissues were significantly correlated with TNM stage and lymph node metastasis of esophageal cancer(P<0.05). The survival curve showed that the 5-year survival rate and expected survival time of patients with CXCL5 and CXCR2 positive esophageal cancer tissues were significantly lower than those with negative esophageal cancer tissues, with a statistically significant difference(P<0.05). Cox multivariate analysis showed that the location of primary tumor, TNM stage of esophageal cancer, lymph node metastasis and the levels of CXCL5 and CXCR2 in esophageal cancer tissues were independent risk factors for the prognosis of esophageal cancer(P<0.05).Conclusion:The high expressions of CXCL5 and CXCR2 in tumor tissues of patients with esophageal cancer are related to the condition of esophageal cancer.CXCL5 and CXCR2 are independent risk factors affecting the prognosis of patients with esophageal cancer.

目的 分析研讨外周中性粒细胞和淋巴细胞比值(NLR)对溃疡性结肠炎疾病活动度的影响.方法 随机从2016年5月～2018年6月期间收治的溃疡性结肠炎患者中抽取80例进行讨论,依据其疾病阶段分组,其中40例为活动期(活动组),另40例为缓解期(缓解组),再选取同时期体检健康者40例作为对照组,测定其NLR值、白细胞计数(WBC)、红细胞沉降率(ESR)、CRP等指标,并评估NLR值判定溃疡性结肠炎活动的特异度、敏感度等.结果 活动组ESR、CRP、WBC、NLR指标均高于缓解组、对照组,组间数据差异有统计学意义(P<0.05),对照组与缓解组相比,组间数据差异无统计学意义(P>0.05).Logistic回归分析ESR、CRP、WBC、NLR变量,结果显示,CRP可评估UC活动度,数据差异有统计学意义(P<0.05);ESR、WBC、NLR则与UC活动度无关.ROC曲线分析后得知,NLR评估UC活动度的特异性和敏感度为63％、56％,截点值2.23,曲线下面积0.802.结论 临床评估溃疡性结肠炎活动度可参考NLR值,但NLR非判定溃疡性结肠炎活动度无独立性,仍需结合其他指标进行综合分析.

目的:分析肠易激综合征(IBS)的临床特点及影响患者病情严重程度的危险因素.方法:选取2017年4月至2018年4月期间徐州医科大学附属医院收治的336例IBS患者作为研究对象.采用自制的调查问卷调查这336例患者的病情.观察调查问卷的结果,分析这336例患者病情的临床特点及影响其病情严重程度的危险因素.结果:这336例患者中,病情间断发作的患者有232例,排便前发生腹痛的患者有202例.在这336例患者中,有283例腹泻型IBS(D-IBS)患者.在这283例D-IBS患者中,未发病时粪便为软便的患者有147例,发病时粪便呈糊状的患者有217例.这336例患者主要的合并症有焦虑、抑郁及睡眠障碍.进行单因素分析的结果显示,这336例患者病情的影响因素包括在未发病时出现腹痛或腹部不适、合并有胃食管反流、功能性消化不良、头痛、焦虑及抑郁(P<0.05).进行多因素Logistic回归分析的结果显示,这336例患者病情的影响因素包括合并有功能性消化不良、焦虑及抑郁(P<0.05).结论:IBS的临床表现较为复杂.此病的临床特点主要为:多数患者的病情呈间断性发作、在排便前常可发生腹痛、D-IBS患者在发病时粪便常呈糊状、D-IBS患者在未发病时大便常为软便.影响IBS患者病情严重程度的危险因素主要是其合并有功能性消化不良、焦虑或抑郁.

目的:探讨用美沙拉嗪治疗溃疡性结肠炎的效果.方法:将2016年2月至2018年4月期间徐州医科大学附属医院收治的80例溃疡性结肠炎患者随机平均分为observation组和control组.为observation组患者使用美沙拉嗪进行治疗,为control组患者使用柳氮磺胺吡啶进行治疗.然后,对比两组患者的治疗效果及其治疗前后血清中各项炎性因子的水平.结果:1)与control组患者相比,observation组患者治疗的总有效率较高(P<0.05).2)治疗前,两组患者血清中TNF-α(肿瘤坏死因子-α)、IL-8(白细胞介素-8)、IL-6(白细胞介素-6)、IL-1β(白细胞介素-1β)的水平相比,P>0.05,差异无统计学意义.治疗后,与control组患者相比,observation组患者血清中TNF-α、IL-8、IL-6、IL-1β 的水平均较低(P<0.05).结果:用美沙拉嗪治疗溃疡性结肠炎的效果显著,可有效地抑制患者体内的炎症反应.