目的 探讨眼局部用药所致干眼的诊断和治疗.方法 对门诊有明确眼局部用药并有干眼症状37例54眼,就诊前既往诊断、眼局部用药情况、治疗前后基础Schirmer、BUT试验和荧光素染色的变化情况进行分析;根据病情给予停用原来的眼药,辅以不含防腐剂的人工泪液(爱丽眼液)和促眼表上皮修复药物(bFGF、EGF).结果 本组病例就诊前眼病诊断主要为慢性结膜炎17眼(31.48%)、病毒性结膜炎9眼(16.67%)、病毒性角膜炎7眼(12.96%)、沙眼5眼(9.23%)、近视滴用保健眼液4眼(7.41%)、青光眼6眼(11.11%)诊断不明确4眼(7.41%)等.既往眼局部用药有氯霉素、无环鸟苷、复方妥布霉素、噻吗洛尔、酮咯酸、地塞米松、萘甲唑林.分别对治疗前和治疗后的基础泪液分泌、BUT进行比较,差异有显著性(P＜0.01).结论 眼科局部用药不当易诱发药物性干眼的产生,应引起足够重视。

Objective:To evaluate the feasibility of argon laser-induced choroidal neovascularization(CNV)model in the pigmental rabbits in order to establish the foundation for studying the mechanism of CNV and for the development of treatment for CNV.Methods:Experimental eyes in 20 rabbits were received a series of 20 argon green laser(514.5nm) lesions per eye (700 mW,50um,0.1s).Fundus fluorescein angiography(FFA) and indocyanine green angiography (ICGA) were performed,then the rabbits were sacrificed immediately,the eyes were enucleated and processed for histopathologic and immunohistochemistry examination on days 3,7,14,21,30.Results:CNV first appeared on day 7 after photocoagulation,reaching the peak on day 21.The incidence of CNV was 63.0%.Disciform leakage staining appeared in the FFA.ICGA showed that the disciform area was filled with CNV.CNV was ascertained by light microscopy.The immunohistochemistry examination of VEGF was positive in ganglion cell layer and inner nuclear layer of retina from 2w after photocoagulation.Conclusion:The present studies demonstrated that argon laser photocoagulation could be used to produce choroidal neovascularization experimental model in the pigmental rabbits.CNV can be induced rapidly by the method,persists for a long period and at a high successful rate.VEGF plays a role in the formation of CNV.

中心性浆液性视网膜脉络膜病变(central serous chorioretinopathy,CSC)是一种常见的眼底病,近年来我们采用氩激光治疗,疗效甚好,报道如下.

目的探讨儿童眼外伤的超声影像特征及其在临床诊断中的价值.方法对经临床证实的231例237眼眼外伤眼球的声像图特征进行回顾性分析.结果发现球内异物101眼、玻璃体积血165眼、视网膜脱离的76眼、脉络膜脱离13眼及其他病变32眼.对上述各种病变的影像进行描述.结论超声检查对指导儿童眼外伤的诊断具有重要临床价值.