Objective:To investigate the correlation between inositol level and glycolipid metabolism in gravidas with gestational diabetes mellitus (GDM).Methods:A cross-sectional study was conducted on 80 GDM cases undergoing routine examination at Fujian Provincial Maternity and Children's Hospital from November 2018 to August 2019, who were selected as GDM groups. Another 50 women with uncomplicated pregnancies during the same period were selected as the control group. Blood and urine inositol level and serum glycolipid profiles were compared between the two groups, and their association was analyzed. Independent or paired-sample t test, Mann-Whitney test, Chi-square (or Fisher's exact) test, and Pearson correlation test were performed for statistical analysis. Results:The serum inositol concentration and high-density lipoprotein (HDL) cholesterol in the GDM group were significantly lower [322.1 ng/ml (279.1-364.1 ng/ml) vs 403.8 ng/ml (391.8-425.3 ng/ml), Z=-7.879; 1.8 mmol/L (1.5-2.0 mmol/L) vs 2.0 mmol/L (1.7-2.2 mmol/L), Z=-2.419; both P<0.05], while the concentration of urine inositol, lipoprotein-a (lipo-a), 0 h-, 1 h-, 2 h-oral glucose tolerance test (OGTT) glucose, fasting insulin, and glycosylated hemoglobin (HbA1c) were significantly higher when comparing to the control group [192.2 ng/ml (171.0-219.9 ng/ml) vs 143.8 ng/ml (121.1-158.6 ng/ml), Z=-6.834; 253.2 mg/L (65.0-349.0 mg/L) vs 148.5 mg/L(46.5-159.3 mg/L), Z=-0.187; 5.0 mmol/L (5.1-5.6 mmol/L) vs 4.4 mmol/L (4.2-4.6 mmol/L), Z=-5.547; 10.0 mmol/L (9.1-11.3 mmol/L) vs 7.8 mmol/L (7.0-8.4 mmol/L), Z=-6.987; 8.6 mmol/L(7.6-9.4 mmol/L) and 6.6 mmol/L (5.7-7.1 mmol/L), Z=-7.100; 18.2 mU/L(10.6-25.9 mU/L) vs 11.0 mU/L (6.3-12.7 mU/L), Z=-4.537; 5.4%(4.5%-5.5%) vs 5.1%(4.9%-5.4%), Z=-3.468; all P<0.05]. (2) Serum inositol concentration was negatively correlated with fasting insulin and 0 h-, 1 h-, 2 h- OGTT glucose level ( r=-0.386, -0.416, -0.350 and -0.407, respectively); urinary inositol concentration was positively correlated with 0 h-, 1 h-, 2 h-OGTT glucose levels ( r=0.402, 0.389 and 0.429, respectively) (all P<0.05). Conclusions:Serum inositol concentration was decreased, and urinary inositol excretion was increased in women with GDM. Measurement of changes in inositol levels during the second trimester may be helpful to assess the metabolic status of pregnant women.

目的 探讨椎管内分娩镇痛对产程及妊娠结局的影响.方法 选取福建省妇幼保健院2017年1月—12月椎管内分娩镇痛经阴道分娩初产妇53例为观察组,随机抽取同期经阴道分娩非镇痛初产妇55例为对照组,比较观察组与对照组产程及妊娠结局(产后2 h出血量、羊水胎粪污染率、新生儿科转入率、缩宫素使用率、阴道检查率和破膜方式).结果 观察组与对照组第一产程分别为7.33(4.50～13.75)h与13.00(10.00～15.00)h,第二产程分别为0.48(0.37～0.74)h与0.75(0.38～1.12)h,总产程分别为8.02(5.10～14.56)h与14.08(10.80～16.25)h,两组相比差异均有统计学意义(Z=-4.085,P<0.001;Z=-2.315,P=0.021;Z=-4.290,P<0.001;);观察组与对照组缩宫素使用率分别为22.6％(12/53)与54.5％(30/55),阴道检查率分别为26.4％(14/53)与58.2％(32/55),两组相比差异均有统计学意义(χ2=11.560,P=0.001;χ2=11.139,P=0.001);观察组第三产程时间、产后2 h出血量、羊水胎粪污染率、新生儿科转入率及人工破膜率与对照组相比,差异无统计学意义(P>0.05).结论 分娩镇痛能有效减轻疼痛,缩短第一、第二产程及总产程,安全可靠,可推广应用于产科分娩.

目的:探讨椎管内分娩镇痛在一次剖宫产术后再次妊娠阴道试产中的可行性.方法:选取2017年1月至12月福建省妇幼保健院收治的一次剖宫产术后再次妊娠阴道试产的孕妇180例.根据是否实施椎管内镇痛分为镇痛组(93例)和非镇痛组(87例),回顾分析两组孕妇的分娩情况与新生儿结局.结果:镇痛组孕妇的中转剖宫产比例低于非镇痛组孕妇[6.45％ (6/93) vs 16.09％ (14/87),P=0.040];两组的阴道试产成功率、产钳助产率比较,差异均无统计学意义(P＞0.05).镇痛组孕妇的第一产程及总产程时间较非镇痛组孕妇明显缩短[8.33(5.50～11.00)h vs 12.50(8.29～14.46)h,8.92(6.19～12.03)h vs 13.03(9.27～15.18)h,Z=-4.69;P均＜0.001],两组间的第二及第三产程时间比较,差异无统计学意义(P＞0.05).镇痛组的缩宫素使用率低于非镇痛组[6.45％ (6/93) vs 25.29％ (22/87),P＜0.001],两组的人工破膜率、产后2h出血量比较,差异无统计学意义(P＞0.05).两组的新生儿出生体质量及出生后1 min Apgar评分比较,差异无统计学意义(P＞0.05).结论:一次剖宫产术后再次妊娠阴道试产的孕妇可在严密监护下行椎管内分娩镇痛,安全可靠,值得临床推广.