目的:探讨在老年骨质疏松患者中,在补钙基础上增加骨化三醇口服对于骨代谢指标的影响.方法:搜集2015年6月至2017年6月期间住在我院骨科的的老年骨质疏松住院患者64例,所有患者年龄大于65岁,根据是否口服骨化三醇分为对照组与治疗组,对照组共32例,每晚口服钙尔奇D 1片,包含钙600 mg,维生素D3125IU;治疗组32例,每晚口服骨化三醇0.25μg联合钙尔奇D 1片,均服药6个月.对比分析两组患者基本指标及骨代谢指标.结果:两组患者临床基本资料无统计学差异,治疗组患者血钙、血磷、碱性磷酸酶、骨碱性磷酸酶、骨钙素、25羟维生素D水平明显高于对照组,差异有统计学意义(P<0.05).Ⅰ型胶原羧基末端肽明显低于对照组,差异具有明显统计学意义(P<0.01).结论:联合应用骨化三醇与钙尔奇D能够明显提高骨形成,降低骨吸收,改善骨代谢,值得临床推广.

目的:晚期非小细胞肺癌中应用恩度的疗效观察.方法:抽选2016年1月～2018年1月在我院治疗的60例晚期非小细胞肺癌患者作为研究对象,随机分为两组,对照组30例,采用常规化疗治疗,观察组30例,在常规化疗的基础上再给予恩度治疗,比较两组的不良反应率、治疗效果等.结果:观察组近期治疗总有效率为83.33％,不良反应发生率(4例,13.33％),疾病进展时间为(8.13±3.07)月,对照组近期治疗总有效率为56.67％,不良反应发生率(7例,23.33％),疾病进展时间为(5.07±3.22)月,观察组临床效果优于对照组,两组比较,有显著差异,P<0.05,具有统计学意义.结论:晚期非小细胞肺癌在常规化疗的基础上联合恩度治疗,有效减少不良反应发生率,延缓了疾病的发展时间,取得比较显著的治疗效果,具有重要的临床研究价值.

Objective To investigate the rational dispensation method of Propacetamol Hydrochloride for Injection,and to ensure the safe-ty and effectiveness of deployment of the finished product. Methods The propacetamol hydrochloride was diluted by volume ratio of 1:50,which were compatible with 0. 9％ Sodium Chloride Injection,5％ Glucose and Sodium Chloride Injection,10％ Glucose Injection, 5％ Glucose Injection and Invert Sugar Injection,and 0. 9％ Sodium Chloride Injection diluted by the volume ratio of 1:100. The mor-phological characteristics of the mixture were observed,and the pH,insoluble particles and content change of propacetamol hydrochloride were measured. Results 0. 9％ Sodium Chloride Injection was chosen as solvent,in accordance with the volume ratio of 1:50 diluted solution of the drug compatibility and good stability in 2 h. There was little change in the content of propacetamol hydrochloride,and the pH and insoluble particles met the requirements. Conclusion 0. 9％ Sodium Chloride Injection should be used as preferred solvent with dilution volume ratio of 1:50 for Propacetamol Hydrochloride for Injection and it should be used in a short time after configured.

目的 探讨按病区排药和按药品排药两种方法对静脉用药调配中心各项工作的影响.方法 共30个工作日,两种排药方法各15 d进行比较.结果 按病区顺序排药时平均每袋静脉输液的花费总时间为152 s,而按药品顺序排药时则为137 s,两组间差异显著;按病区顺序排药时平均每袋静脉输液排药、核对和配液环节的时间分别为26.3、28.3和54.1 s,而按药品顺序排药时则分别为19.9、28.4和44.5 s,两组间差异显著;结论 排药可提高工作效率降低差错率,应作为首选方法.

Objective To investigate the interference of urine cephalosporins in the detection of urinary occult blood when dry chemical urine analysis was applied.Methods The treated samples,composed of healthy volunteers' urine,red blood cells and cephalosporins,were fully mixed according to a certain proportion.The control samples were prepared in the same way but without the addition of cephalosporing.All samples were assayed by dry chemical urine analysis.Results The detected numbers of red blood cells were decreased significantly in treated samples than those in the control samples and the decrease were cephalosporins dose-dependent.The false-negative occult blood results in treated sample were found when urine cephalosporins was ≥20 mg/L.Conclusion Cephalosporins may interfere in the quantitative results of occult blood test,or even lead to false-negative results.

目的 介绍医院儿科开展静脉用药集中调配优越性与可能存在的问题.方法 结合<静脉用药集中调配质量管理规范>对儿科开展静脉用药集中调配的好处和可能存在的问题进行分析.结果 儿科开展静脉用药集中调配能增加用药的安全性,减少输液反应,但由于儿科输液量偏少,配置耗费时间较多.结论 儿科开展静脉用药集中具有一定的优越性,但由于静脉用药调配中心是为全院所有科室服务,日配置量大,所以儿科不适合集中调配.