Glioma is the most common primary intracranial tumor and is related to poor clinical outcomes. The developments of sensitive markers can be applied to reveal the mechanisms involved in the progression of glioma. This study examined CDCA2 expression in glioma samples and its significance in predicting glioma patient outcome. GEPIA and GEO datasets were used to explore the expression of CDCA2 in glioma. Kaplan-Meier and multivariate assays were applied to delve into the prognostic values of CDCA2 expression in glioma patients using CGGA datasets. Our group also determined the associations between CDCA2 and clinical characteristics. Coexpression analysis was performed. In this research, we observed that CDCA2 expression was distinctly upregulated in glioma specimens compared with nontumor specimens. The prognosis of glioma with high CDCA2 expression was distinctly worse compared with that of glioma with low CDCA2 expression. Additionally, multivariate Cox regression analysis revealed that high CDCA2 expression was an independent poor prognostic indicator for glioma patients. High expression of CDCA2 was positively associated with advanced clinical progression. Coexpression analysis revealed that CDCA2 could be positively related to ASPM, SKA1, DLGAP5, NCAPG, and CDCA8 and was negatively associated with ETNPPL, LDHD, MRVI1, CBX7, and CENPJ. Overall, our findings revealed that CDCA2 might serve as an independent prognosis indicator for glioma.

目的:研究微创穿刺联合开颅减压治疗高血压脑出血致脑疝患者的疗效及预后.方法:选择2017年6月至2018年2月于广东三九脑科医院就诊的50例高血压脑出血致脑疝患者,按照随机数字法分为对照组和观察组,各25例.对照组行常规开颅血肿清除术及去骨瓣减压术,观察组采取微创穿刺引流联合开颅减压的术式,比较两组患者临床疗效、巴氏指数(BI)评分、格拉斯哥预后量表(GOS)评分及并发症发生率.结果:观察组的总有效率为96.00％,显著高于对照组的72.00％,差异具有统计学意义(P＜0.05);观察组术后3个月BI评分高于对照组,差异具有统计学意义(P＜0.05);观察组GOS评分Ⅳ、Ⅴ级人数占比高于对照组,差异具有统计学意义(P＜0.05).结论:微创穿刺联合开颅减压治疗高血压脑出血致脑疝疗效较好,明显改善患者的预后.

目的 总结颅脑手术术中超声在非术区急性脑出血的应用经验.方法 回顾性分析5例颅脑外科手术中突发非术区出血的病例资料,均应用术中超声观察与寻找非术区脑出血,并引导术者清除血肿.结果 术中均证实为非术区脑出血,术中超声诊断准确率达100％.术中超声检查显示:手术同侧非术区脑出血4例,对侧出血1例.术中均即刻进行处理,其中血肿完全清除4例,部分清除1例.结论 颅脑手术术中超声能快速评估手术异常情况,迅速定位出血部位,评价血肿清除效果.

自1998年以来,我科对320例肛肠病手术患者行局部麻醉,效果满意,现报告如下.