目的:探讨司库奇尤单抗治疗寻常性银屑病疗效及对患者皮损程度、炎性反应的影响.方法:选取96例寻常性银屑病患者,随机分为试验组(48例)和对照组(48例),对照组采用阿维A、复方甘草酸苷、卡泊三醇和卤米松软膏治疗,试验组采用司库奇尤单抗治疗.比较治疗前后两组患者病情严重程度[银屑病面积严重程度指数(PASI)、皮损面积(BSA)]、生活质量[皮肤病生活质量指数(DLQI)]及血清细胞因子[白细胞介素-17(IL-17)、白细胞介素-10(IL-10)、白细胞介素-22(IL-22)]的变化情况,观察司库奇尤单抗治疗寻常性银屑病患者的效果,并分析不良反应发生情况,随访患者复发率.结果:治疗12周后,试验组疗效优于对照组(P＜0.05),两组患者的PSAI、BSA、DLQI评分、血清IL-17、IL-22水平均低于治疗前,且试验组显著低于对照组(均P＜0.05).两组患者的血清IL-10水平高于治疗前,且试验组显著高于对照组(P＜0.05).治疗结束后随访3个月期间,试验组复发率显著低于对照组(P＜0.05).结论:司库奇尤单抗治疗寻常性银屑病疗效确切,可缓解患者病情严重程度,有效抑制炎性反应,提高其生活质量,并有利于改善患者预后.

Objective To observe the effect of Secukinumab in the treatment of severe plaque psoriasis and its influence on skin lesions. Methods A total of 76 patients with severe plaque psoriasis admitted to our hospital from July 2021 to February 2022 were randomly divided into control group and observation group, with 38 cases in each group. The control group was treated with calcipotriol ointment, and the observation group was treated with secukinumab. The PASI score, skin lesion symptom score, inflammation level, quality of life and adverse reactions were compared between the two groups. Results The PASI scores of the observation group were lower than those of the control group after 2, 4 and 8 weeks of treatment, and the differences were statistically significant (P ＜0.05). The scores of pruritus, erythema, scales and skin lesion area in the observation group were lower than those in the control group, and the differences were statistically significant (P ＜0.05). The levels of TNF-α and IL-17 in the observation group were lower than those in the control group, and the level of IL-10 was higher than that in the control group, the differences were statistically significant (P ＜0.05). The quality of life score of the observation group was higher than that of the control group, and the differences were statistically significant (P ＜0.05). The incidence of adverse reactions in the observation group was lower than that in the control group, and the differences were statistically significant (P ＜0.05). Conclusion Secukinumab can achieve a good effect in the treatment of patients with severe plaque psoriasis, which can improve the symptomatic area and skin lesions, reduce the level of inflammation, improve their quality of life, with less adverse reactions and good safety.

目的 探究于重度痤疮治疗中采用光动力疗法对临床疗效的影响.方法 研究分析对象均为本院皮肤科收治的重度痤疮患者,共计76例,病例纳入时间为2018年1月至2019年11月,依据蓝红双色进行1-38数列分布均分病例,38例予以常规治疗,设为常规组,38例予以光动力疗法,设为光疗组.结果 持续治疗8周后,光疗组疗效判定有效率97.37％ (37/38),常规组疗效判定有效率81.58％ (31/38),差异有统计学意义(P＜0.05);持续医学追踪患者6个月,光疗组患者无复发病例,常规组6例患者复发,光疗组复发病例少于常规组,差异有统计学意义(P＜0.05).结论 于重度痤疮治疗中采用光动力疗法,利于皮损转归,可为临床疗效增益,降低复发率.

Objective To observe the effect of kangfuxin liquid combined with eshaneé medical cold paster on patients with facial dermatitis. Methods A total of 120 patients with facial dermatitis within 2 weeks were diagnosed in department of dermatology of fifth people's hospital of datong city from January 2018 to January 2019, the patients were randomly divided into in the control group, the kangfuxin liquid group, the medical cold paster group and the combined group,each group has 30 patients, the control group was treated with general treatment, the experimental group was treated with kangfuxin liquid, the medical cold paster, and kangfuxin liquid combined with wet compress and cold spray.Compared the skin recovery and patient satisfaction within one week.Results After one week, the skin recovery and patient satisfaction in the experimental group were significantly different from those in the control group, and there were also significant differences between the combined treatment group and the single treatment group(P<0.05). Conclusion Kangfuxin liquid combined with medical cold paster wet compress is helpful to speed up the improvement of skin flushing in facial dermatitis, promote the repair of skin and improve the satisfaction of patients.

探求在对性传播疾病患者诊治过程中实施医学人文关怀对提高患者治疗依从性、促进其早日康复和减少性传播疾病蔓延的意义.通过对大同市第五人民医院实施人文关怀培训后接诊的100例性传播疾病患者与人文关怀培训前接诊的73例普通患者诊治的对比研究,主要包括接诊、治疗与治疗后三个阶段的全程人文关怀及特殊人群的针对性人文关怀.研究显示,与实行人文关怀前相比,实施人文关怀的100例患者的治疗依从性明显提高.由此可见,医学人文关怀在性传播疾病诊治中的实施是可行且有效的.

目的:探讨坦索罗辛治疗前列腺增生的临床效果及安全性.方法:收治前列腺增生患者80例,分为对照组和试验组.对照组采用盐酸特拉唑嗪治疗,试验组采用坦索罗辛治疗,比较两组治疗效果.结果:试验组前列腺症状、生活质量评分改善程度和不良反应发生率均优于对照组(P<0.05).结论:坦索罗辛治疗前列腺增生的临床效果显著,安全性高.

目的:探讨心理治疗对寻常型银屑病患者疗效及生活质量的影响.方法:收治寻常型银屑病患者100例,分为对照组与研究组.对照组采用常规治疗,研究组在常规治疗基础上联合心理治疗.结果:治疗前两组PASI、DLQI、SAS、SDS评分差异无统计学意义(P>0.05),治疗后两组均有改善,研究组改善更明显(P<0.05);对照组治疗总有效率明显低于研究组(P<0.05).结论:结合寻常型银屑病患者的疾病特点,在常规治疗基础上联合心理治疗,能改善患者的生活质量,提高临床治疗效果.

目的:探讨不同剂量泼尼松联合泛昔洛韦治疗带状疱疹的临床疗效.方法:选择86例带状疱疹患者作为观察对象,随机分为小剂量组(43例,应用小剂量泼尼松联合泛昔洛韦治疗)和大剂量组(43例,应用大剂量泼尼松联合泛昔洛韦治疗).对比小剂量组和大剂量组患者的止疱时间、疱疹消退时间及不良反应发生率.结果:小剂量组患者止疱时间、疱疹消退时间和大剂量组无显著差异(P>0.05),大剂量组患者不良反应发生率(16.28％)比小剂量组(2.33％)明显更高(P<0.05).结论:在泛昔洛韦治疗的基础上对带状疱疹患者实施小剂量泼尼松治疗的效果和大剂量泼尼松较相似,且小剂量的安全性更高.

目的:分析经皮肾镜气压弹道超声碎石术在肾结石治疗中的临床效果与安全性.方法:回顾性分析80例肾结石患者,分为对照组与联合超声组,各40例.对照组采用经皮肾镜气压弹道碎石术,联合超声组采用经皮肾镜气压弹道超声碎石术治疗,比较2组肾结石治疗效果、平均住院日数、手术实施时间、下床活动时间、治疗前后患者肾功能指标及并发症情况.结果:联合超声组肾结石治疗效果优于对照组(P＜0.05);联合超声组下床活动时间与对照组之间无明显差异,平均住院日数、手术实施时间短于对照组(P＜0.05);治疗后2组肾功能指标优于治疗前(P＜0.05),治疗后联合超声组肾功能指标和对照组之间无显著差异(P＞0.05).联合超声组并发症发生率低于对照组(P＜0.05).结论:经皮肾镜气压弹道超声碎石术在肾结石治疗中的临床效果与安全性高于单纯经皮肾镜气压弹道碎石术,可缩短手术时间和住院时间,减少并发症,对肾功能无明显影响.