Objective To access the therapeutic effects of metformin to adolescents with polycystic ovary syndrome(PCOS).Methods Thirty patients with PCOS,aged 15 to 25 years,were treated by metformin,850 mg twice daily for twelve weeks.The changes of the following indexes after administration were observed: body weight,blood pressure,menstruation,testosterone(T),luteohormone(LH),follicle stimulating hormone(FSH),estradiol(E_2),LH/FSH,triglyceride(TG),total cholesterol(TC),high density lipoprotein-cholesterol(HDL),lower density lipoprotein-cholesterol(LDL),fasting blood glucose(FBG),2 h postprandial blood glucose(PBG),insulin(INS).The body mass index(BMI) and insulin sensitivity index(ISI) were also calculated.Results After the treatment with metformin,the BMI,the levels of INS,T,LH and LH/FSH ratio were decreased significantly(P0.001) and ISI was increased significantly(P0.001).The levels of FBG,TC,TG,and LDL were also improved(P0.05 or 0.01).The average value of diastolic blood pressure was significantly different among groups(P0.01) and 73.3% of patients(22/30) resumed normal menstruation.Conclusion Metformin can improve insulin resistance,hyperinsulinaemia,decrease the plasma levels of T and LH,and LH/FSH ratio,resume menstrual cycle.At the same time,it also can improve blood pressure,and regulate glucose and lipid.

Objevtive To study leptin and lipid metabolism in type 2 diabetic patients with fatty liver.Methods Selected 200 inpatients and outpatients in endocrinology department of Yuhuangding Hospital randomly of which 89 patients were with fatty liver,111 patients without fatty liver,a set of examinations including clinic history,biochemical test,leptin,C-peptide and liver ultrasound were carried out.Results Body mass index(BMI)((27.68)±(4.00)) kg/m~2 vs ((24.72)±(3.07)) kg/m~2,triglyceride(TG)((2.88)±(3.19)) mmol/L vs((1.74)±(1.18)) mmol/L,1 h C-peptide((4.23)±(2.87)) μg/L vs((2.32)±(1.97)) μg/L,2 h C-peptide((4.43)±(2.93)) μg/L vs((2.71)±(1.54)) μg/L and leptin((13.08)±(8.88)) μg/L vs((8.63)±(5.45)) μg/L in type 2 diabetes with fatty liver group were higher than in type 2 diabetes without fatty liver group.The result of logistic regression indicates that 1 h C-peptide,leptin,and TG are associative with fatty liver(r=(0.005),(0.002),(0.040)).Conclusion TG,1 h C-peptide and leptin are important associative factors in the patients of type 2 diabetes with fatty liver disease.

目的　对86例老年糖尿病人机会感染进行研究，探讨其发病机制、常见机会致病菌及临床特点。　方法　从住院的老年糖尿病人中筛选机会感染者86例，分析其致病菌、感染部位、血糖、血浆蛋白、血纤维蛋白原、血红蛋白及尿蛋白等。　结果　主要危险因素是高血纤维蛋白原、低白蛋白血症和高血糖等。常见的感染部位是泌尿系统、呼吸系统、双足、躯体皮肤及败血症；常见的机会致病菌有葡萄球菌、大肠埃希菌、肺炎克雷白菌及链球菌。　结论　老年糖尿病人易发生机会感染，致病菌呈多样性，在抗感染治疗中应积极改善器官功能和支持治疗。

目的探讨老年糖尿病患者康复过程中严重皮肤感染发病机制、临床表现及常见致病菌.方法回顾性分析38例皮肤损伤原因、感染好发部位及常见致病菌,分析入院时生化指标.结果皮肤损伤多因护理不当和保护知识缺乏,感染多发生在足部,其次是背部及臀部;病原菌多为条件致病菌,以金黄色葡萄球菌最多见;其中高血糖、高纤维蛋白原、低白蛋白血症及贫血为独立危险因素.结论老年糖尿病患者康复治疗过程中易发生皮肤感染,对糖尿病患者教育及护理是预防严重皮肤感染的关键.

调查Ⅱ型糖尿病患者239人,其中伴有DR者104人,列为DR组,对两组病程、血压、血脂、血糖、C肽、尿酸、BMI、HbA1c、纤维蛋白原(Fg)进行单因素及多因素分析.结果DR组病程、Ch、2hBG、2hc-p及Fg明显高于对照组.logistic多因素回归分析显示DR与病程及Fg密切相关.结论:DR的防治应侧重于控制餐后高血糖、降低胆固醇及纤维蛋白原.