目的:观察黄连青饮治疗风热型急性咽炎的临床疗效.方法:将152例风热型急性咽炎患者随机分为对照组与观察组各76例,两组患者均给予常规治疗,观察组在常规治疗基础上给予黄连青饮汤剂口服,观察比较两组患者治疗效果.结果:两组患者症状均明显改善,且观察组患者咽痛、咽干灼热、咽部黏膜充血、咽痒咳嗽、发热等症状改善情况优于对照组,差异具有统计学意义(P＜0.05).结论:黄连青饮治疗风热型急性咽炎效果明显,值得临床推广应用.

Objective:to observe the curative effect of San Ao Tang with Lingguizhugan on facilitating expectoration, suppressing cough and relieving dyspnea. Methods:1) suppressing cough:the mice were divided into high and low dosage groups of combined for-mula, high and low dosage groups of Lingguizhugan Tang, high and low dosage groups of San Ao Tang, Guilong Kechuangning Cap-sule group, Kebiqing group and control group. Each group was given intragastric administration to observe the function of suppressing cough by mouse concentrated ammonia-induced cough. 2) facilitating expectoration:the mice were randomly divided into model group, high and low dosage groups of combined formula, high and low dosage groups of Lingguizhugan Tang , high and low dosage groups of San Ao Tang, Guilong Kechuangning Capsule group and NH4CL (ammonium Chloride) group. The function of facilitating expectora-tion was observed by mice trachea phenolsulfonphthalein excretion quantity method. 3 ) relieving dyspnea: the preselected qualified sensitive guinea pigs were randomly divided into combined formula group, Lingguizhugan Tang group, San Ao Tang group, aminolhyl-line group and control group. Prepare water solutions of Lingguizhugan Tang and San Ao Tang , and mixed liquor of both solutions with the same volume. Except aminolhylline group with intraperitoneal injection, the others were administered with atomization, 15 min a day for three days. Mix the same volume of 2% acecoline and 0. 1% histamine phosphate to induce asthma so to observe the latency period in guinea pigs. Results:1) suppressing cough:the latency period in the high dosage group of combined formula was prolonged, compared with control group, with significant difference, P <0. 05;compared with both groups of San Ao Tang , the period was pro-longed without significant difference; compared with both groups of Lingguizhugan Tang , the period was prolonged with significant difference, P <0. 05. 2) facilitating expectoration:mice trachea phenolsulfonphthalein excretion quantity detection showed that all the dosage groups could increase mice trachea phenolsulfonphthalein excretion quantity with significant difference compared with control group, P <0. 05. And the combined formula group was superior to others. 3) relieving dyspnea:there was significant difference in the latency periods between the combined formula group and control and Lingguizhugan Tang groups, P <0. 05; compared with San Ao Tang group, the difference was significant, P <0. 05. Conclusion:the combined formula of San Ao Tang with Lingguizhugan can sig-nificantly suppress cough, facilitate expectoration and relieve dyspnea, which is superior to San Ao Tang or Lingguizhugan Tang , with dose-effect relationship.

乳疾灵颗粒为国家中药保护品种,由淫羊藿、丹参、鸡血藤等多味中药配伍制成,主要用于治疗乳腺增生症.为考察本品长期给药是否会产生蓄积毒性,参照有关文献进行了大鼠毒性观察.

乳疾灵对大鼠棉球肉芽肿及醋酸所致急性渗出性炎症有明显抑制作用,小鼠醋酸扭体法表明其镇痛作用明显.其浓缩膏1.3g/kg和2.6g/kg剂量可明显缩小家兔乳腺增生模型的乳腺体积,减少乳腺小叶和腺泡数,明显降低血中雌二醇的浓度,病理学检查显示对实验性乳腺增生有明显抑制作用.