目的 研究低浓度N2O清醒镇痛在高龄患者结肠镜检查中的安全性和有效性.方法 将2012年5月至2016年6月行N2O清醒镇痛结肠镜检查的520例≥70岁高龄患者作为观察组,同期常规行结肠镜检查的580例≥70岁高龄患者作为对照组,观察2组患者术前、术中、术后心率(HR)、血氧饱和度(SPO2)、血压(BP)情况,以及检查满意率及不良反应发生情况.结果 观察组术中HR、SPO2、BP与对照组比较差异有统计学意义(P<0.05),且观察组满意率高于对照组,不良反应明显低于对照组,差异有统计学意义(P<0.05).结论 低浓度N2O清醒镇痛用于结肠镜检查提高了老年患者结肠镜检查的舒适度和安全性,临床效果良好.

Objective To investigate the effectiveness and safety of nitrous oxide for colonoscopy and evaluate its clinical ap-plication value.Methods A total of 532 patients were randomly divided into N2 O group ( inhalation with nitrous oxide ) and O2 group ( inhalation with pure oxygen) .The heart rate( HR) and blood oxygen saturation ( SPO2 ) were observed before, during, and after the colonoscopy.The reaction and feeling of patients and doctors were evaluated by visual analogue scale( VAS) .Results There was not significant difference in HR and SPO2 between the N2O group and O2 group.The satisfaction rate of both doctors and patients in the N2O group was higher than O2 group,withsignificant difference(P<0.01).Conclusions Nitrous oxide for colonoscopy is comfortable and safe, and is worthy of widespread use.