Objective To analyze the clinical effect of CO2 lattice laser combined with salicylic acid in the treatment of depressed scar after acne. Methods A total of 60 patients with depressed scar after acne admitted to our hospital from January 2021 to June 2022 were selected as the research objects and divided into control group and observation group according to the random number table method, with 30 cases in each group. The control group was treated with CO2 lattice laser, and the observation group was treated with Borda salicylic acid on the basis of the control group. The skin status (skin texture value and skin pore value), clinical efficacy, quality of life and adverse reactions were compared between the two groups. Results The scores of quality of life in the observation group were higher than those in the control group (P ＜0.05). The incidence of adverse reactions in the observation group was 6.67％, which was lower than 33.33％ in the control group (P ＜0.05). The total effective rate of the observation group was 90.00％, which was higher than 66.67％ in the control group (P ＜0.05). The scores of skin texture value and skin pore value in the observation group were lower than those in the control group (P ＜0.05). Conclusion CO2 lattice laser is a common and effective method for the treatment of acne scars in clinic. Lattice laser combined with salicylic acid therapy for the treatment of depressed acne scars can achieve better clinical efficacy, improve the skin state of patients, improve the quality of life of pati ents, and have fewer adverse reactions.

目的:观察寻常型银屑病患者血清肽基脯氨酰顺反异构酶1(Pin1)、摄食抑制因子1(nesfatin-1)、血管生成素2(ANGPT2)水平的变化,并探讨分析其临床意义.方法:选择我院2019年5月～2021年5月收治的寻常型银屑病患者98例,分别比较不同疾病严重程度和不同疾病分期患者的血清Pin1、nesfatin-1、ANGPT2水平,采用Pearson检验分析血清Pin1、nesfatin-1、ANGPT2水平与皮损面积及严重程度指数(PASI)评分的相关性,采用光疗仪对患者进行治疗,比较治疗前后血清Pin1、nesfatin-1、ANGPT2水平变化.结果:重度组和中度组患者的Pin1、ANGPT2水平均高于轻度组,且重度组高于中度组(P＜0.05);重度组和中度组患者的nesfatin-1水平均低于轻度组,且重度组低于中度组(P＜0.05).进行期组患者的Pin1、ANGPT2水平高于静止期组和退行期组患者,而nesfatin-1水平低于静止期组与退行期组患者(P＜0.05);静止期组与退行期组之间上述各指标比较差异无统计学意义(P＞0.05).Pearson相关性分析结果显示,寻常型银屑病患者的血清Pin1、ANGPT2水平与PASI评分呈正相关,而nesfatin-1水平与PASI评分呈负相关(P＜0.05).治疗后,寻常型银屑病患者的血清Pin1、ANGPT2水平明显降低,nesfatin-1水平则明显升高(P＜0.05).结论:寻常型银屑病患者的病情越重,血清Pin1、ANGPT2水平越高,而nesfatin-1水平越低,且三者对患者疗效有一定评估价值.

目的:探讨光动力联合CO2激光治疗对尖锐湿疣患者外周血T淋巴细胞亚群及炎性因子的影响.方法:收集在我院接受治疗的尖锐湿疣患者临床资料,基于特定时间段内(2020年2月-2021年2月)对其进行选取(80例),将所有选取患者的病例信息均输入Excel系统,按照系统编号的单双数分为2组(各40例),以SPSS23.0为统计工具,其中40例双数者联合光动力治疗,将其设为A组,另40例单数者选择CO2激光治疗,将其设为B组,就A组、B组治疗效果展开对比.结果:A组临床疗效(95.00％)显著高于B组(80.00％)(P<0.05);治疗后,A组CD3+、CD4+、CD4+/CD8+显著高于B组(P<0.05),CD8+显著低于B组(P<0.05);治疗后,A组炎性因子水平显著低于B组(P<0.05);不良反应:A组(7.50％)显著低于B组(25.00％)(P<0.05).结论:该研究具有可行性.

目的:探讨加巴喷丁、多塞平联合治疗方案应用于带状疱疹神经痛治疗中的效果.方法:共纳入贵阳市第二人民医院收治的86例带状疱疹神经痛患者(2020年1月至2021年6月入院)作为研究对象,以随机分组方式分为参照组和治疗组(各43例),两组均接受常规抗病毒治疗,在此基础上参照组行加巴喷丁治疗,治疗组在以上治疗基础上联合多塞平,比较治疗效果.结果:较参照组79.07％,治疗组治疗有效率95.35％更高(P＜0.05).治疗前,两组患者疼痛评分、血清疼痛介质水平、血清炎性因子水平相似(P＞0.05).治疗后,较参照

1 临床资料 患者,男,21岁,因“躯干红斑1年,全身潮红、脱屑伴瘙痒1月余”于2016年2月21日就诊我院.患者1年前无明显诱因于躯干出现散在红斑,伴瘙痒,无发热、关节疼痛、腹痛等不适,自行购买“氯雷他定片、马来酸氯苯那敏片、醋酸泼尼松片”(具体剂量不详)口服,治疗后瘙痒好转,皮疹消退,但停药后瘙痒加重,皮疹反复并逐渐增多.1月前,患者皮疹泛发全身,头面部、躯干、四肢出现潮红、肿胀、脱屑,伴剧烈瘙痒,伴发热体温波动于:(39.5 ～42.0)℃、咳嗽、咳痰,无腹痛、腹泻、关节疼痛等不适,遂至当地医院就诊,诊断为“1.肺炎2.胸腔积液查因3.皮疹查因4.肝肾功能不全查因”.予抗感染、抗过敏治疗,无明显好转.为进一步诊治来我院,门诊拟“红皮病查因”收入我科.发病以来睡眠、精神、饮食欠佳,二便正常,体重无明显变化.否认糖尿病、高血压、心脏病病史,无药物、食物过敏史.既往史、个人史、婚育史、家族史无特殊.

Leprosy is a chronic infectious diseasecaused by Myc-obacterium leprae. Majorviolations of human skin and nerves, if not treatment can cause permanent damage to the skin, nerves, etc. At present, Chinese treatment of leprosy prevention, and for those patients who have been suffering from leprosy, treatment is also worth studying deeper exploration. The research method of this article is through the T cellreceptor gene drift a chain V region each family CDR3 immune pedigree analysis technique to monitor leprosy patient TCR a chain CDR3 pedigree, and preliminary analysis of CDR3 PCR products and TRAVcloning of quantitative hyperplasia of the family, in order to provide a new research direction for T cell immune response changes after the patients infected with leprosy.