Objective To investigate the effects of calcitonin gene-related peptide ( CGRP ) on renal interstitial fibrosis and expression of Inflammatory cytokines in mice with unilateral ureteral obstruction (UUO).Methods The animal models with UUO were established in 36 mice.The mice in treatment group were given CGRP 1.0nmol · kg-1 · d-1 by intravenous injection,however,the mice in model group were given equivalent 0.9% sodium chloride solution by intravenous injection.The mice in both groups were sacrificed after 14-day administration,then the percentage of renal tubular lesion ,the extent of renal interstitial fibrosis , number of renal interstitial macrophage cells , the expression levels of renal interstitial expression of α-smooth muscle actin (α-SMA), monocyte chemotactic protein-1 (MCP-1) and F4/80 mRNA were observed and compared between two groups .Results CGRP alleviated significantly renal tubular lesion and renal interstitial fibrosis (P<0.05 ).The expression levels of α-SMA and macrophages number in renal interstitial in treatment groups were significantly lower than those in model group ( P <0.05).Moreover CGRP inhibited significantly the expression levels of MCP-1 and F4/80 mRNA ( P <0.05).Conclusion CGRP can reduce macrophage infiltration of mice with UUO ,decrease the expression levels of MCP-1 and F4/80 mRNA,inhibit the expression of α-SMA so as to relieve renal interstitial fibrosis .

患者 男,24岁.因吞咽困难,声音嘶哑1个月,左侧舌肌颤动4 d入院.查体:左侧舌肌萎缩,伸舌左偏.颅脑CT及MRI提示斜坡中下段占位病变并向左侧岩骨尖部生长,病变骨质呈膨胀性破坏.T1WI为稍低信号混杂影,T2WI为较高信号混杂影;病变内可见斑点状、片状钙化.入院诊断:岩斜区占位病变.左枕远外侧入路硬膜外切除肿瘤.术中刮出物为红褐色沙砾样组织,大小约3 cm×3 cm ×5 cm,质地坚硬,血运欠丰富.病理诊断:软骨母细胞瘤.镜下可见软骨母细胞呈中等大小,圆形,境界清楚,胞质丰富淡红色或透明,核大位于细胞中央,多呈圆形或卵圆形,核仁不明显,有核纵沟。

患者 女,54岁.因头外伤3 d伴头痛恶心入院.3 d前患者乘坐汽车,因道路颠簸,头顶碰在车顶上,当时受力局部头痛,2 d前出现持续性全头胀痛.入院查体:无明显阳性体征.患者既往体健,近来未服用任何药物,月经不规律,尚未绝经.凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原、凝血酶时间各项值均正常.头CT提示:窦汇、右侧横窦、部分矢状窦、直窦血栓形成.入院诊断:硬膜窦血栓.

许多研究表明,原发性高血压常伴发左心室肥厚 (LVH),LVH是心血管疾病的独立危险因素,与心功能减退、室性心律失常、猝死密切相关.LVH的逆转可能与预后的改善有关.本研究旨在利用超声心动图检查LVH及质量指数,探讨辛伐他汀长期治疗对原发性高血压患者LVH的影响.