Objective:To investigate the clinical application value of frameless stereotactic electroencephalography (SEEG) electrode implantation assisted by domestic Remebot robot in patients with drug-refractory epilepsy.Methods:Ten patients with medically-refractory epilepsy, admitted to and accepted SEEG electrode implantation assisted by domestic Remebot robot in our hospital from October 2021 to March 2022, were chosen in our study. Epileptogenic focuses of these patients were determined. Bone Fiducial Markers were used for registration during surgery, and the registration error and implantation time of each electrode were recorded in detail. Thin-layer CT scan was performed immediately after surgery to observe the occurrence of complications. Three-dimensional reconstruction of all implanted electrodes was performed postoperatively, which was fused with the preoperative surgical planning paths and targets, and the electrode entry point error and target error were calculated.Results:SEEG electrodes were implanted in all 10 patients with the assistance of frameless surgical robot, and the resection areas were accurately determined according to the results of SEEG records. The registered error of these 10 patients was (0.24±0.03) mm. A total of 97 SEEG electrodes were implanted, and the average effective implantation time of each electrode was (6.3±1.2) min. After the fusion of three-dimensional electrode reconstruction with preoperative surgical plan, the mean entry point error of 97 electrodes was (1.9±1.2) mm, and the mean target error was (2.1±1.2) mm. Immediate postoperative head CT showed that none of the 10 patients had surgical complications such as intracranial hemorrhage or severe pneumoencephalos.Conclusion:The SEEG electrode implantation assisted by Remebot frameless robot is safe, accurate, and effective, which can meet the clinical needs.

Objective:To investigate the ototoxicity of cisplatin on distortion product otoacoustic emissions(DPOAE)and high frequency audiometry. Methods:DPOAE,conventional pure tone audiometry and expanded high frequency audiometry were examined in 24 gynecologic cancer patients before and after the first time of cisplatin administration.DPOAE amplitudes,conventional pure tone hearing thresholds and expanded high frequency hearing thresholds were compared statisticaolly.Results:After cisplatin administration, the pure tone hearing thresholds at expanded high frequency area incseased significantly,DPOAE amplitudes at frequency from 3 to 4 kHz and expanded high frequency area declined significantly too.The obvious change occurred in group of age from 19 to 29.No auditory chauges were foumd in patients(50~65 years old).Conclusion:DPOAE is a potential implement to early detect dectection of the ototoxicity of cisplatin.The susceptibility to cisplatin maybe declined while patient's age have increased.

Objective: To investigate the result of distortion product otoacoustic emissions(DPOAE)and expanded high frequency audiometry in noise exposure workers. Methods: DPOAE, conventional pure tone audiometry and expanded high frequency audiometry were examined in 42 young adults with normal hearing and 20 noise exposure workers. DPOAE amplitudes, conventional pure tone hearing thresholds and expanded high frequency hearing thresholds were compared. Results: In noise exposure workers against young adults with normal hearing, the pure tone hearing thresholds at 6 kHz and expanded high frequency area declined significantly,DPOAE amplitudes at frequency from 4 to 6 kHz and 11.2 kHz declined obviowly too,but there existed no significantly difference at frequency from 12.5 to 16 kHz between the two groups. Conclusion:DPOAE is potential implement to early diagnose and detect noise-induced deafness. The originated area and mechanism of DPOAE should be solved by further studies.