Connection of an immune system with infection agents defines the further development of infectious diseases especially rotavirus infection (RVI). The state of immune system before the beginning of disease and an adequacy of immune answer to causative agent defines the possibility of disease and its heaviness, duration of an acute period, cyclicity, time of pathogens elimination and period of reconvalescence. The humoral link is one of important components of immune system.Methods. 96 children 1 month-5 years old with acute intestinal infections of rotavirus etiology were under observation. 51 children with mono-variant of rotavirus infection formed the 1 group. The 11 group included 45 patients with mixed-variant of rotavirus infection. The control group included 32 practically healthy children. The research was carried out at the high point of disease (1–3 day) and in period of reconvalescence. (5–6 day). The study of humoral link of immunity was carried out using the method of radial immunodiffusion in agar on Mancini G.Results. At comparison of indicators of the humoral link of immune system in children with mono- and mixed-variants of RVI at admission to hospital it was established that Ig М concentration in children of the 1 group was higher (р<0,05), and Ig G level in blood serum lower(р<0,05) than in the 11 group. So the study of the humoral immunity in blood serum in children with rotavirus infection revealed changes that were presented as an increase of Ig М and IgG indicators and also decrease of IgА. An assessment of an immune system after treatment within this research is characterized with an increase of IgА and IgG and decrease of IgМ.Conclusions. In blood serum of children with mono- and mixed-variants of rotavirus infection in an acute period of disease there was observed decrease of Ig А concentration and increase of Ig М і IgG. In the period of reconvalescence in children with mono- and mixed-variants of an acute intestinal infection of rotavirus etiology the humoral link of immune system is characterized with a tendency to increase of Ig М, there was no improvement on the other indicators. At comparative characteristic of the studied groups it was established that in children with mono-variant of rotavirus infection was detected the reliable decrease of immunoglobulin M concentration and increase of immunoglobulin G comparing with mixed-variant of rotavirus gastroenteritis

The opbjective of the study is to determine the features of the colon microbiocenosis in children with community-acquired pneumonia depending on concomitant mild iron deficiency anemia. Materials and methods. The study involved 48 patients with community-acquired pneumonia and 18 apparently healthy children. Bacteriological study of intestinal microflora was conducted by the method of Epstein-Litvak. The findings showed that the intestinal microflora of patients with community-acquired pneumonia is different from that of healthy individuals. Colon microflora in children with community-acquired pneumonia as a whole is characterized by reduced obligate bacteria (bifidobacteria, normal E.coli, lactobacilli) and the growth of opportunistic pathogenic microflora. The colon of patients with community-acquired pneumonia, associated with iron deficiency anemia, is characterized by more significant change in the microbiota (deficiency of bifidobacteria, lactobacilli, reduced total number of E.coli and rising titer of Staphylococcus, yeast-like fungi, opportunistic pathogenic microflora). Thus, impaired bowel microbiota in children with community-acquired pneumonia associated with iron deficiency anemia may be a reason to include probiotic preparation into the complex of pathogenetic therapy.