This study aimed to evaluate the efficacy and safety of anlotinib combined with limb salvage therapy in patients with osteosarcoma after chemotherapy failure. A retrospective study was conducted on 46 eligible osteosarcoma patients who failed chemotherapy, admitted to our hospital from October 2021 to December 2022. They were divided into 2 groups: 28 patients in the anlotinib combined with limb salvage surgery group (combined group) and 18 patients in the limb salvage surgery alone group (surgery group). The primary endpoint was progression-free survival (PFS); secondary endpoints included objective response rate, disease control rate, overall survival (OS), and adverse events (AEs). Therapeutic efficacy was evaluated by response evaluation criteria in solid tumors 1.1, and AEs were graded by common terminology criteria for adverse events v4.0. The median PFS in the combined group was 4.8 months (95% confidence interval: 3.5-7.1 months), significantly longer than that in the surgery group (2.8 months, P < .05). The objective response rate and disease control rate in the combined group were 39.29% and 67.86%, respectively, which were numerically higher than those in the surgery group (16.67% and 38.89%). Common AEs in the combined group included anorexia, leukopenia, and elevated transaminases, with significantly higher incidence than in the surgery group (P < .05); hypothyroidism was more common in the surgery group (P < .05). Anlotinib combined with limb salvage therapy shows favorable efficacy in prolonging PFS and improving disease control in chemotherapy-refractory osteosarcoma patients, with manageable adverse reactions. It may be a viable option for such patients.

The development of bone adhesives capable of restoring natural bone structure and function represents a pioneering advancement in surgical technology, offering significant potential to improve the treatment outcomes of comminuted fractures. However, the development of a clinically demand-driven adhesive, ensuring both reliable adhesion and osteogenic activity, poses a significant challenge. Herein, a structurally and functionally dual-biomimetic bone adhesive is developed through the design of an organic-inorganic network-enhanced hydrogel, which integrates caffeic acid-grafted collagen (CAC), aminated laponite (ALAP), and N-hydroxysuccinimide ester-terminated polyethylene glycol (tetra-PEG-SC). Benefiting from nanosheet-induced strengthening, the mechanically reinforced adhesive can maintain integrity under extreme compression (98%) and tensile (600%) deformations, facilitating anatomical repositioning of rabbit radius and porcine femur fractures. Of greater importance, the adhesive accelerated fracture healing, potentially via ROS scavenging and immunomodulation, as evidenced by reduced oxidative stress and M2 macrophage polarization in vitro. Assessed through an innovative rabbit radius comminuted fracture model, the injectable bone adhesive demonstrates rapid and flexible adhesion of bone fragments in a blood-rich environment, as observed over the 2 fold improvement in biomechanical and radiological performance compared with commercially available cyanoacrylate adhesives. This intricately designed bone adhesive holds promise as a novel solution for addressing complex fracture cases in surgical treatment.

Osteosarcoma is a type of aggressive malignant bone tumor that may cause severe pain and pathological fractures to patients. The preferred treatment for the femoral bone tumors is limb salvage surgery, which requires an accurate delineation of tumor regions from pre-operative MR and CT images. However, tumor images are characterized by high intra-class variation and low inter-class distinction, making it challenging to generate accurate segmentation. We propose a novel plug-and-play multi-cue integration (MCI) module that leverages attention mechanisms to selectively aggregate features learned from complementary-tasks. The aim is to enforce shape-prior leveraging the existing target labels. Two types of complementary-tasks including (1) reverse distance field (RDF) regression and (2) tumor edge detection are proposed to encode the geometric properties of the femoral bone tumors. The proposed MCI module is then plugged into the decoder layers of the state-of-the-art (SOTA) nnUNet (we refer the nnUNet with the plugged-in MCI module as MCI-nnUNet) to enable shape-aware complementary-task learning for accurate tumor segmentation. We designed and conducted comprehensive experiments on an in-house dataset consisting of 75 paired CT and MR volumes of the femoral bone tumor. MCI-nnUNet achieved an average Dice similarity coefficient of 90.19±3.22

This study was to evaluate the efficacy of soft tissue reconstruction using synthetic mesh and a medial gastrocnemius flap in patients who underwent proximal tibial hemiarthroplasty after resection of proximal tibial bone sarcomas. A retrospective cohort study was conducted on 102 skeletally immature children (58 males, 44 females) who underwent proximal tibial Hemiarthroplasty between January 2005 and December 2023. The most common diagnoses were osteosarcoma (95

BACKGROUND:The reconstruction options for Enneking II/II+III pelvic tumors-defined as periacetabular tumor with or without involving the pubis or ischium-remain controversial. Short-term outcomes of ipsilateral femoral head autograft for the reconstruction of acetabular defects have been reported in limited case series studies. However, the long-term stability and complications of this method remain unknown. QUESTIONS/PURPOSES:At a minimum of 5 years of follow-up: (1) What was the graft survival rate in patients who underwent pelvic Enneking II/II+III tumor resections using an ipsilateral autologous femoral head graft for reconstruction? (2) What were the radiologic outcomes? (3) What were the functional outcomes, and what factors were independently associated with poor functional outcomes (Musculoskeletal Tumor Society Score [MSTS]-93 scores < 80%)? (4) What percentage of patients experienced complications, and what were they? METHODS:Between January 2007 and June 2020, we surgically treated 583 patients with Enneking II/II+III pelvic tumors. Ten percent (61 of 583) of patients underwent amputation, 57% (335 of 583) underwent curettage, and the remaining 32% (187 of 583) underwent en bloc resection. During the period in question, we generally used en bloc resection in patients with primary pelvic tumors, invasive benign pelvic tumors, and metastatic pelvic tumors. Patients who underwent en bloc resection were considered potentially eligible for inclusion. This study only included patients who underwent Enneking II/II+III pelvic tumor resections with partial preservation of the acetabulum and ipsilateral femoral head autograft reconstruction and who had 5 years or more of follow-up. Twenty-one percent (120 of 583) of patients were excluded because they received other reconstruction methods. Although 2% (10 of 583) of patients had < 5 years of follow-up or were lost to follow-up, some patients may have experienced failure or complications prior to 5 years or at the time of loss to follow-up. Consequently, these patients should still be included, leaving 10% (57 of 583) of patients for analysis. The mean ± SD age at diagnosis was 41 ± 13 years, and the mean follow-up time was 11 ± 3 years. Fifty-one percent (29 of 57) of patients were men. The most common pathologic diagnoses were giant cell tumor of bone (42% [24 of 57]) and chondrosarcoma (35% [20 of 57]). At the last follow-up, 84% (48 of 57) of patients had no evidence of disease, 9% (5 of 57) were alive with disease, and 7% (4 of 57) died of disease. The graft cumulative removal rate and revision rate were estimated using the competing risk estimator. We used preoperative and postoperative thin-section CT scans to assess the displacement of the hip rotation center. We classified complications into major and minor complications according to whether patients underwent unplanned reoperation. The MSTS-93 score was used to assess functional outcomes. Preoperative and postoperative CT scans were used to assess the displacement distance of the hip rotation center and the femoral neck. Cox regression analysis was used to evaluate risk factors associated with poor postoperative functional scores (MSTS-93 < 80%). RESULTS:The cumulative implant removal rates at 2 years and 5 years were 2% (95% confidence interval [CI] 0.3% to 8%) and 5% (95% CI 1% to 13%), respectively. The revision rates at 2 years and 5 years were 10% (95% CI 4% to 18%) and 15% (95% CI 7% to 25%), respectively. The median (range) MSTS-93 score was 90% (57% to 100%). Sixteen percent (9 of 57) of patients developed a total of 11 complications, including five major complications and six minor complications. The most common complications were infection (5% [3 of 57]), delayed wound healing (5% [3 of 57]), and hip dislocation (4% [2 of 57]). After controlling for potential confounding variables such as gender, age, and previous surgery, we found that abductor muscle resection (cause-specific HR 2.9 [95% CI 1.3 to 6.1]; p = 0.012) was an independent risk factor associated with poor function. CONCLUSION:Among patients with Enneking II/II+III pelvic tumors with partial preservation of the acetabulum, ipsilateral autologous femoral head autografting combined with hip arthroplasty is a viable reconstructive approach. For patients who cannot undergo tumor prosthesis or allograft reconstruction because of difficulties in obtaining grafts, costs, or social and/or religious reasons, this reconstruction technique may be considered. Additionally, we do not recommend this surgery for patients with complete acetabular resection, as autologous femoral head transplantation is insufficient to completely compensate for bone defects. Future studies with larger sample sizes should compare the advantages and disadvantages of this reconstruction technique with prosthetic or biological reconstruction and focus on clarifying the patient indications for existing reconstruction techniques. LEVEL OF EVIDENCE:Level IV, therapeutic study.

Aims:Reconstruction after periacetabular tumour resection poses significant challenges in limb salvage surgery, particularly in the management of its complications and in optimizing functional outcome. This study aims to compare the outcomes of prosthetic reconstruction and hip transposition, and to develop a preoperative scoring system to assist surgical decision-making. Methods:Between January 2007 and December 2022, 197 patients underwent periacetabular tumour resection at two medical centres. Among them, 52 received prosthetic reconstruction and 62 underwent hip transposition, all with complete clinical and surgical data and postoperative follow-up. Inverse probability of treatment weighting and propensity score matching were applied to balance baseline preoperative variables. Surgical factors (e.g. operating time, blood loss, surgical margins) and postoperative outcome, including functional results and complications, were compared between groups. A preoperative scoring system was developed to predict the risk of major complications using Cox regression analysis and was validated through receiver operating characteristic analysis. Results:The Musculoskeletal Tumor Society (MSTS) scores showed no significant difference between the prosthetic reconstruction and hip transposition groups. However, the prosthetic group had a higher rate of complications requiring additional surgery, which was associated with decreased MSTS scores. Notably, patients in this group without complications had the highest functional outcomes. This trend remained consistent after adjusting for baseline characteristics. Hip transposition had a safer overall profile, while prosthetic reconstruction achieved better restoration of limb length and earlier mobilization. Based on these findings, we developed and internally validated a preoperative scoring system which included tumour region, gluteal invasion, and operation status to predict the risk of major complications (area under the curve = 0.77). Conclusion:Prosthetic reconstruction for periacetabular tumours is associated with a higher complication rate, potentially compromising functional outcome, while hip transposition is a safer and more conservative option. The proposed preoperative scoring system may help surgeons to choose the more appropriate reconstructive strategy based on the individual patient risk profile.

The proximal humeral reconstruction is challenging. This study aims to investigate the survival, function and complications of clavicla pro humero (CPH) for pediatric proximal humeral reconstruction. A retrospective cohort study was conducted on eight patients (4 males, and 4 females) who underwent clavicla pro humero reconstruction between January 2009 and December 2020 in our institution. The average age was 10.4 ± 2.7 years (range, 6 to 14 years). The functional outcomes were assessed by the Musculoskeletal Tumor Society Score (MSTS-93), the Toronto Extremity Salvage Score (TESS), the American Shoulder and Elbow Surgeons (ASES) score and the range of motion (ROM) of the shoulder. The complications and overall survivorship of clavicla pro humero were recorded in the follow-up. The mean follow-up of all patients was 54.6 ± 23.9 months (range, 24 to 84 months) and 73.3 ± 8.5 months (range, 72 to 84 months) in all survivors. All patients had a bone union at an average of 3.8 months after the initial procedure. Only one patient had no complications in the follow-up. The most common complications were clavicle fracture (87.5

Abstract Background Soft tissue recurrence of giant cell tumor of bone (GCTB) is rare. This study aims to provide its prevalence, recurrent locations, risk factors, effective detection methods and a modified classification for this recurrence. Methods Patients with soft tissue recurrence after primary surgery for GCTB were screened from January 2003 to December 2022. General data, recurrence frequency, types according to an original classification (type-I: peripheral ossification; type-II: central ossification; type-III: without ossification), a modified classification with more detailed subtypes (type I-1: ≤ 1/2 peripheral ossification; type I-2: ≥ 1/2 peripheral ossification; type II-1: ≤ 1/2 central ossification; type II-2: ≥ 1/2 central ossification; type III: without ossification), locations, detection methods such as ultrasonography, X-ray, CT or MRI, Musculoskeletal Tumor Society (MSTS) scores were recorded. Multivariate regression analysis was conducted to identify risk factors for recurrence frequency. Results A total of 558 recurrent cases were identified from 2009 patients with GCTB. Among them, 32 were soft tissue recurrence. The total recurrence rate was 27.78% (558/2009). Soft tissue recurrence rate was 5.73% among 558 recurrent cases, and 1.59% among 2009 GCTB patients, respectively. After excluding one patient lost to follow-up, 10 males and 21 females with the mean age of 28.52 ± 9.93 (16–57) years were included. The definitive diagnosis of all recurrences was confirmed by postoperative pathology. The interval from primary surgery to the first recurrence was 23.23 ± 26.12 (2–27) months. Eight recurrences occurred from primary GCTB located at distal radius, followed by distal femur (6 cases). Recurrence occurred twice in 12 patients and 3 times in 7 patients. Twenty-seven recurrences were firstly detected by ultrasonography, followed by CT or X-ray (10 cases in each). Types at the first recurrence were 5 cases in type-I, 8 in type-II and 18 in type-III. According to the modified classification, 3 patients in type I-1, 2 in type I-2, 1 in type II-1, 7 in type II-2, and 18 in type III. The mean MSTS score was 26.62 ± 4.21 (14—30). Neither Campanacci grade nor recurrence type, modified classification and other characters, were identified as risk factors. Conclusions Soft tissue recurrence of GCTB may recur for more than once and distal radius was the most common location of primary GCTB that would suffer a soft tissue recurrence. Ultrasonography was a useful method to detect the recurrence. Since no risk factors were discovered, a careful follow-up with ultrasonography was recommended.

The accurate extraction of accurate boundary of bone tumor is a prerequisite for surgical planning in robotic bone tumor resection. Current research mainly focuses on anatomy-based automatic or semi-automatic segmentation. We notice that besides the anatomically visible envelope of bone tumor, the responsive region should also be considered for the safe robot-assisted bone tumor resection. Based on this idea, this paper taking the femoral bone tumor as an example, proposes a bone tumor boundary extraction method incorporating envelope and responsive region for robot-assisted R0 resection. First, we automatically extract the envelope model of bone tumor utilizing the neural network and simplified its mesh model using the quadric edge collapse decimation algorithm. Then, we extend the envelope model to get preliminary bone tumor boundary model covering the responsive region using an offset along with the surface point normal of the envelope model. Finally, we calculate the intersection between the preliminary bone tumor boundary and the femoral condyle model to get the resulting bone tumor boundary. A case with clinical images is tested and assessed by surgeon which demonstrates the feasibly of the proposed method for robot-assisted accurate R0 resection.

目的 探讨合并腰椎退变的梨状肌综合征患者手术治疗效果.方法 分析2014年至2021年于郑州大学第一附属医院应用经椎间孔椎体间融合术(TLIF)治疗的合并腰椎退变的梨状肌综合征患者29例;根据日本矫形学会评分(JOA)、视觉模拟评分(VAS)、功能障碍指数(ODI)对患者手术前、手术后1周及末次随访进行评分.结果 本组29例患者均成功实施TLIF术;手术时间为(116.17±19.50)min;术中出血量为(310±105)ml,患者术后1周JOA评分高于术前[(20.83±2.79)分比(16.17±3.31)分,t=5.797,P＜0.05].患者末次随访VAS评分低于术前[(1.67±0.82)分 比(6.33±1.21)分,t=17.169,P＜0.05],患者末次随访ODI评分低于术前[(17.00±4.73)分比(34.67±5.35)分,t=13.325,P＜0.05].影像学检查结果显示所有患者手术节段均正常融合,椎间隙骨性愈合情况良好.27例患者接受TLIF处理后相关症状获得明显改善;2例患者接受TLIF处理后,梨状肌综合征相关症状缓解不理想,二次接受"坐骨神经松解术"处理,手术后相关症状缓解满意.结论 对于合并腰椎退变的梨状肌综合征患者,TLIF技术可有效改善患者疼痛、JOA评分及ODI指数,也能通过间接减压骶神经丛,使梨状肌综合征的相关症状得到明显的缓解.

Osteosarcoma is a malignant bone tumor occurring in adolescents. Surgery combined with adjuvant or neoadjuvant chemotherapy is the standard treatment. However, systemic chemotherapy is associated with serious side effects and a high risk of postoperative tumor recurrence, leading to a high amputation rate and mortality in cancer patients. Implant materials that can simultaneously repair large bone defects and prevent osteosarcoma recurrence are in urgent need. Herein, an intelligent system comprising 3D-printed titanium scaffold (TS) and pH-responsive PEGylated paclitaxel prodrugs was fabricated for bone defect reconstruction and recurrence prevention following osteosarcoma surgery. The drug-loaded implants exhibited excellent stability and biocompatibility for supporting the activity of bone stem cells under normal body fluid conditions and the rapid release of drugs in response to faintly acidic environments. An in vitro study demonstrated that five human osteosarcoma cell lines could be efficiently eradicated by paclitaxel released in an acidic microenvironment. Using mice models, we demonstrated that the drug-loaded TS can enable a pH-responsive treatment of postoperative tumors and effectively prevent osteosarcoma recurrence. Therefore, local implantation of this composite scaffold may be a promising topical therapeutic method to prevent osteosarcoma recurrence.

Multiple myeloma (MM) is a neoplasm of aberrant plasma cells and ranks second among hematologic malignancies. Despite a substantial improvement in clinical outcomes with advances in therapeutic modalities over the past two decades, MM remains incurable, necessitating the development of new and potent therapies. Herein, we engineered a daratumumab-polymersome-DM1 conjugate (DPDC) based highly potent and CD38-selective immuno-nano-DM1 toxin for depleting MM cells in vivo. DPDC with controllable daratumumab density and disulfide-linked DM1 is of small size (51-56 nm), with high stability and reduction-triggered DM1 release. D6.2PDC potently inhibited the proliferation of CD38-overexpressed LP-1 and MM.1S MM cells with IC50 values of 2.7 and 1.2 ng DM1 equiv. per mL, about 4-fold stronger than non-targeted PDC. Moreover, D6.2PDC effectively and safely depleted LP-1-Luc MM cells in an orthotopic mouse model at a low DM1 dosage of 0.2 mg kg(-1), thus alleviating osteolytic bone lesion and extending the median survival by 2.8-3.5-fold compared to all controls. This CD38-selective DPDC provides a safe and potent treatment strategy for MM.

Osteoarthritis (OA) is the most common type of arthritis and the leading cause of disability globally. It tends to occur in middle age or due to an injury or obesity. OA occurs with the onset of symptoms, including joint swelling, joint effusion, and limited movement at a late stage of the disease, which leads to teratogenesis and loss of joint function. During the pathogenesis of this degenerative joint lesion, several local inflammatory responses are activated, resulting in synovial proliferation and pannus formation that facilitates the destruction of the bone and the articular cartilage. The commonly used drugs for the clinical diagnosis and treatment of OA have limitations such as low bioavailability, short half-life, poor targeting, and high systemic toxicity. With the application of nanomaterials and intelligent nanomedicines, novel nanotherapeutic strategies have shown more specific targeting, prolonged half-life, refined bioavailability, and reduced systemic toxicity, compared to the existing medications. In this review, we summarized the recent advancements in new nanotherapeutic strategies for OA and provided suggestions for improving the treatment of OA.

EDITORIAL article Front. Pharmacol., 20 September 2022Sec. Experimental Pharmacology and Drug Discovery Volume 13 - 2022 | https://doi.org/10.3389/fphar.2022.1016631

目的 评估颈椎椎旁肌退变与颈椎退行性改变之间的相关性.方法 回顾性分析2019年10月至2021年6月因颈部疼痛或根性症状至郑州大学第一附属医院就诊的147例患者,其中男51例,女96例,年龄18～79[50.00(40.00,55.00)]岁.通过Image J软件测量MRI图像中C3～6椎体水平椎管的前后径(AP)、浅层颈伸肌横截面积(SEA)、深层颈伸肌横截面积(DEA)、椎体横截面积(VBA)以及脂肪浸润率(FIR).通过影像归档和通信系统(PACS)在MRI图像上评估C3～6层面椎间盘的退变分级及Modic改变.采用Spearman相关性分析对颈伸肌退变与颈椎退行性改变的关联性进行分析.结果 C3～4节段的AP与C3～6水平的DEA/VBA比值(r=0.168,r=0.216,r=0.223,r=0.232)具有相关性;Modic改变与椎旁肌参数无相关性;颈椎间盘退变在C4～5节段与C3～6水平的颈深伸肌群FIR(r=0.168,r=0.234,r=0.251,r=0.211)具有相关性,C4～5节段与 C3～6水平的颈浅伸肌群 FIR(r=0.234,r=0.273,r=0.307,r=0.209)具有相关性,C6～7节段与C3～6水平的颈浅伸肌群FIR(r=0.291,r=0.261,r=0.256,r=0.253)具有相关性.结论 颈椎椎旁肌退变与颈椎退行性改变之间存在相关性.

Objective:To analyze the correlation between the occipital-cervical fusion angle and the long-term changes in the curvature of the lower cervical spine.Methods:A total of 28 patients with atlantoaxial dislocation or skull base depression who were treated in the First Affiliated Hospital of Zhengzhou University from June 2001 to June 2011 were selected. All patients received posterior occipital-cervical fixation and fusion. The OC2A and C2-C7 Cobb angles were measured by cervical X-ray films, and the data were collected and measured before surgery, after surgery and during follow-up. The patients were divided into groups A, B, and C according to the fusion angle. Spearman correlation was used in the correlation analysis between the occipital-cervical fusion angle and the curvature of the lower cervical spine was performed.Results:Among the 28 patients, there were 12 males and 16 females; the age was (38.5±12.4) years; the follow-up time was (158.25±62.34) months. The OC2A fixation angle of 5 patients in group A was within 10°, and the OC2A value of the 5 patients after operation was statistically significant at 6 months after operation, 5 years after operation and at the last follow-up ( P<0.01). The 4 patients in group C were fixed above 20°, and the differences in C2-C7 Cobb angle were statistically significant at 6 months after operation, 5 years after operation and at the last follow-up ( P<0.01). In group C, the OC2A value was negatively correlated with the C2-C7 Cobb angle ( r=-0.797, P<0.01). Conclusion:OC2A has a significant correlation with the C2-C7 Cobb angle, and an appropriate one should be selected when performing posterior occipital-cervical fixation and fusion. The occipital-cervical fusion angle should be within 20° for OC2A. An OC2A exceeding 20° may cause long-term degeneration of the lower cervical spine or even reverse arch.

Development of versatile theranostic agents that simultaneously integrate therapeutic and diagnostic features remains a clinical urgent. Herein, we aimed to prepare uniform PEGylated (lactic-co-glycolic acid) (PLGA) microcapsules (PB@(Fe3O4@PEG-PLGA) MCs) with superparamagnetic Fe3O4 nanoparticles embedded in the shell and Prussian blue (PB) NPs inbuilt in the cavity via a premix membrane emulsification (PME) method. On account of the eligible geometry and multiple load capacity, these MCs could be used as efficient multi-modality contrast agents to simultaneously enhance the contrasts of US, MR and PAT imaging. In-built PB NPs furnished the MCs with excellent photothermal conversion property and embedded Fe3O4 NPs endowed the magnetic location for fabrication of targeted drug delivery system. Notably, after further in-situ encapsulation of antitumor drug of DOX, (PB+DOX)@(Fe3O4@PEG-PLGA) MCs possessed more unique advantages on achieving near infrared (NIR)-responsive drug delivery and magnetic-guided chemo-photothermal synergistic osteosarcoma therapy. In vitro and in vivo studies revealed these biocompatible (PB+DOX)@(Fe3O4@PEG-PLGA) MCs could effectively target to the tumor tissue with superior therapeutic effect against the invasion of osteosarcoma and alleviation of osteolytic lesions, which will be developed as a smart platform integrating multi-modality imaging capabilities and synergistic effect with high therapy efficacy.

目的 研究骨质疏松与腰椎间盘退变之间的关系.方法 回顾性收集2019年10月至2021年3月于郑州大学第一附属医院骨科就诊的258例腰腿痛患者的资料.测量患者腰椎常规平扫CT及磁共振影像资料数据.根据患者L1椎体的平均CT值进行分组,CT值>160 HU为骨量正常组(85例),CT值为100～160 HU为骨量减少组(91例),CT值<100 HU为骨质疏松组(82例).使用Pfirrmann分级系统对腰椎间盘退变进行评分.用Spearman相关性分析椎体CT值与腰椎间盘退变的相关性.结果 除L2/3节段外,其余节段腰椎间盘退变评分组间比较差异有统计学意义(P<0.05);除L2/3节段外,骨质疏松组腰椎间盘退变评分高于骨量正常组和骨量减少组(P<0.05);骨量减少组腰椎间盘退变评分与骨量正常组比较,差异无统计学意义(P>0.05).L1/2、L3/4、L4/5、L5/S1及L1～S1椎间盘退变评分均与L1 CT值呈负相关(P<0.05).结论 骨质疏松与腰椎间盘退变具有正性相关的关系.

Damage and degeneration to bone and articular cartilage are the leading causes of musculoskeletal disability. Commonly used clinical and surgical methods include autologous/allogeneic bone and cartilage transplantation, vascularized bone transplantation, autologous chondrocyte implantation, mosaicplasty, and joint replacement. 3D bio printing technology to construct implants by layer-by-layer printing of biological materials, living cells, and other biologically active substances in vitro, which is expected to replace the repair mentioned above methods. Researchers use cells and biomedical materials as discrete materials. 3D bio printing has largely solved the problem of insufficient organ donors with the ability to prepare different organs and tissue structures. This paper mainly discusses the application of polymer materials, bio printing cell selection, and its application in bone and cartilage repair.

[目的]分析颈后路单开门椎板成形术后颈伸肌(neck extensor muscle,NEM)与颈椎矢状位参数变化,探讨术后NEM萎缩与颈椎矢状位参数变化的相关性.[方法]2015年1月—2019年7月于本院行颈后路单开门椎板成形术的患者共128例,于术前、术后1周,术后1、2年行影像检查,测量C2-7Cobb角、C2-7SVA、T,斜率,以及NEM的丰度(SEA/VBA和DEA/VBA)及脂肪变性率.并进行相关分析.[结果]随时间推移,C2-7SVA、C2-7Cobb角、T1S,以及SEA/VBA、DEA/VBA和脂肪含量均显曲线变化,各时间点间差异均有统计学意义(P＜0.05).Spearman相关分析表明,SEA/VBA和DEA/VBA均与C2-7 Cobb角的变化呈正相关(P＜0.05).NEM脂肪含量与C2-7Cobb角的变化呈负相关(P＜0.05).C7T1的NEM脂肪含量与T1S的变化呈正相关(P＜0.05).[结论]颈后路单开门椎板成形术后颈椎出现后凸改变的趋势,NEM萎缩与颈椎矢状位参数的变化具有相关性.