“Binaural beats” (BB) is a type of sound stimulus being studiedas non-invasive tools to promote sleep. BB is a sensation occuringwhen two monotonous sounds of slightly different pitch are suppliedto the listener’s right and left ear separately. This type of stimulationhas the advantage to be perceived even at very low sound volumesessentially bordering the hearing threshold, so such a stimuluscreates little disturbance to sleep. However, the patterns of itseffect are difficult to study due to the weakness of electric brainwaveresponse. The purpose of present paper is to check applicabilityof the brainwave entrainment hypothesis to auditory stimuli withembedded BB delivered during short-term human nap. The results demonstratevariability of auditory steady state response (ASSR) depending onBB frequency of the stimulus as well as on sleep stage that is not envisagedby the above hypothesis. It should be taken into account when predictingthe effect of BB-based noninvasive sleep aids. Furthermore, theanalysis of ASSR spectra allows the hypothesis to be put that thehuman brain falling asleep is a self-adjusting system in relationto incoming sound stimuli, for it strengthens the elements of auditoryresponse which contribute to deepening of naturally evolving sleep.

We studied the effect of collagen fragments (PGP and AcPGP) on serum content of epinephrine, corticosterone, and IL-1β in rats subjected to water-immersion stress. The degree of local inflammation accompanying ulceration was assessed by IL-1β production by ln. gastricus caudalis cells. In 1 h, the sharp increase in hormone concentrations in the blood of stressed animals reflected the high stress intensity. Intranasal administration of PGP reduced the area of stress-induced ulcers by 63%, prevented the increase in the levels of stress hormones and the main proinflammatory cytokine in rat blood. The concentrations of IL-1β in cell culture from regional lymph node of experimental animals returned to normal in 24 and 48 h after the stress. Acetylation of PGP prevents with gastroprotection, but does not abrogate other properties of the peptide.

The paper describes formation of abnormal conditions with the use of alcohol in a laboratory experiment. The generally accepted experimental model are evaluated from the point of view of their suitability for oculographic studies of operator activity. Recommendations for the use of these methods in oculographic study are given.

In article data about functional reserves of organism of the students in adaptation period in changed environment are presented.

The features of development of external respiration development and anthropometric indices in children living in different climatic-geographic and ecological conditions have been studied. It has been shown that at the age from 11 to 15 y.o., growth and development of the respiratory system in children in the examined climatic-geographic regions were significantly different. In children of the Vladimir region, there was observed the most rapid increase in body mass, body mass index, forced respiratory capacity from 11 to 13 y.o. in contrast to children from Kalmykia where the period of the most rapid growth and development is observed at the age 13-15 y.o.