Objective Local vibration can cause microcirculatory abnormalities such as blood stasis and symmetrical intermittent digital artery vasospasm. Finger SBP (FSBP) measurement is a potential way of assessing vascular components. This study aims to comprehensively investigate the relationship between the occurrence of the vibration-induced white finger (VWF) and changes in FSBP and then set the application value of FSBP measurements in the early diagnosis of VWF. Methods All samples were judgmental sampling from one factory. Totally 50 patients with VWF were the case group, while 50 without occupational hand-transmitted vibration exposure were the control group. FSBP measurements and epidemiological feature investigations were taken. Results There were significant reductions in FSBP level and %FSBP index at both 10 °C and 30 °C in fingers reported VWF (P < 0.05). The %FSBP abnormal rate of the index, ring and little finger in the VWF group was higher than the control (44.00% vs. 18.00%, 78.00% vs. 26.00%, 64.00% vs. 8.00%). The %FSBP of the ring and little finger had a relatively high application value (area under curve = 0.902, 0.737), while their standard regression coefficients were −0.23 and −0.412. The diagnostic cutoff value of the ring finger was 77.60%, while the sensitivity and specificity were 86.67%. Conclusion FSBP measurements were proven helpful in monitoring and diagnosing VWF prospectively and proved to have great application value in our study. %FSBP of the ring finger was the appropriate diagnostic index in FSBP measurements, while its abnormal value could be set as 80.00%.

人类基因组在转录水平上非常活跃,有超过98％的被转录为非编码RNA(ncRNAs)[1]. 这其中微小RNA(miRNAs)是一种由内源基因编码的,成熟后包含 18～24 个核苷酸的单链RNA分子[2] ,它主要通过靶向抑制信使RNA即mRNA的3′ 非翻译区(3′UTR)翻译或促进相应的降解调控基因表达两种方式影响其编码mRNA翻译成蛋白质,在大分子水平上调控基因的表达.

选择60名健康成年男性作为对照组,30名接触手传振动(HTV)的男性工人作为接振组,进行职业健康特征以及指端收缩压(FSBP)采集,计算健康人群的医学参考值范围;比较10℃以及15℃下对照组FSBP指数(％FSBP)的差异,并分别绘制两种温度下除大拇指外四指的受试者工作特征(ROC)曲线,预测FSBP诊断手臂振动病(HAVD)的价值.结果显示,食指至小指的％FSBP医学参考值上限10℃时分别为 99.08％、102.46％、107.83％、105.49％,15℃时分别为 130.71％、145.29％、137.34％、136.89％;10℃时食指、中指、无名指的曲线下面积(AUC)分别为0.825、0.880、0.755(P＜0.05),10℃时小指以及15℃时四指的AUC均P＞0.05.提示％FSBP检测在HAVD及其他振动性血管损伤疾病早期诊断中的应用价值较高;首选指标可以定为10℃le时的中指％FSBP,异常判定值可设为79.88％.

选取某运动器材厂208名工人进行健康问卷调查和职业健康体检,并进行指端振动觉阈值(VPT)检测,采用多因素线性回归分析指端VPT的影响因素.结果显示,接振组(92人)手指麻木、刺痛、白指的发生率均高于对照组(116人)(P＜0.05),食指低频、高频VPT随接振工龄的增长呈递增趋势.接振工龄、手指麻木、手指刺痛对食指低频及小指低频、高频VPT具有正向预测作用(P＜0.05),接振工龄、手指刺痛对食指高频VPT具有正向预测作用(P＜0.05).

目的 探究手传振动(HTV)作业工人指端温度觉阈值(TPT)水平及其影响因素,为早期诊断手臂振动病(HAVD)提供依据.方法 对某运动器材公司187名工人开展横断面研究,其中接振组69人、对照组118人.采用HVLab温度觉测试仪进行测量,多元线性回归分析指端TPT的影响因素.结果 接振组工人主力手食指与小指的热觉阚值水平[(46.4±5.7)℃、(45.8±5.6)℃]均高于对照组[(43.4±4.7)℃、(43.7±4.2)℃](P＜0.05),且中性区范围[(22.8±8.9)℃、(24.7±9.3)℃]均大于对照组[(18.3±7.6)℃、(21.2±7.8)℃](P＜0.05);接振组主力手食指冷觉阈值[M(P25,P75)]24.3(21.0,27.5)℃低于对照组[26.2(22.7,28.3)℃](P＜0.05).多元线性回归分析显示,年龄、身高和手指麻木为主力手食指热觉阈值和中性区的影响因素(P＜0.05),手指麻木为主力手冷觉阈值的影响因素(P＜0.05).年龄对主力手小指温度觉阈值和中性区具有正向预测作用(P＜0.05).结论 长期暴露于HTV会导致接振工人指端TPT变化,且接振工龄、年龄和手指麻木是TPT的影响因素.

Local vibration can induce vascular injuries, one example is the hand-arm vibration syndrome (HAVS) caused by hand-transmitted vibration (HTV). Little is known about the molecular mechanism of HAVS-induced vascular injuries. Herein, the iTRAQ (isobaric tags for relative and absolute quantitation) followed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomics approach was applied to conduct the quantitative proteomic analysis of plasma from specimens with HTV exposure or HAVS diagnosis. Overall, 726 proteins were identified in iTRAQ. 37 proteins upregulated and 43 downregulated in HAVS. Moreover, 37 upregulated and 40 downregulated when comparing severe HAVS and mild HAVS. Among them, Vinculin (VCL) was found to be downregulated in the whole process of HAVS. The concentration of vinculin was further verified by ELISA, and the results suggested that the proteomics data was reliable. Bioinformative analyses were used, and those proteins mainly engaged in specific biological processes like binding, focal adhesion, and integrins. The potential of vinculin application in HAVS diagnosis was validated by the receiver operating characteristic curve.

近年来,温度觉阈值(thermotactile perception threshold,TPT)被推荐用于评估手传递振动(hand-transmitted vibration,HTV)所致的小感觉神经功能的变化,我国早已将指端TPT测试列为HTV作业人员职业健康监护的选检项目之一.研究发现,随着时间推移,温度觉损伤与振动接触水平之间存在显著的剂量-反应关系.本文主要针对TPT在手臂振动病(hand-arm vibration disease,HAVD)所致神经损伤方面的检测特点和应用进行综述.