BACKGROUND:To evaluate magnetic resonance imaging (MRI)-visible perivascular spaces (PVSs) as an imaging marker of glymphatic function in neonatal hypoxic-ischemic encephalopathy (HIE) and to assess the diagnostic utility of a combined clinical-PVS model. METHODS:This retrospective study included 266 neonates with HIE, categorized as mild (n = 50) or moderate-to-severe (n = 216). PVS burden in the basal ganglia (BG) and white matter was assessed on T2-weighted imaging using visual grading and volumetric quantification. Logistic regression models (clinical vs combined clinical-PVS vs traditional MRI injury pattern model) were constructed, with performance evaluated by the area under the receiver operating characteristic (ROC) curve (AUC) and decision curve analysis. RESULTS:A significant severity-dependent reduction in PVS metrics was observed in the BG. Neonates in the moderate-to-severe group exhibited significantly lower BG PVS fractions compared to the mild group (P < 0.001). Multivariate analysis identified BG PVS fraction and clinical indicators as independent predictors of severity. The combined clinical-PVS model achieved an AUC of 0.82, which was significantly higher than the AUC of 0.69 yielded by the traditional MRI injury pattern model (P < 0.05). CONCLUSIONS:HIE severity is characterized by a progressive reduction in BG PVS, suggesting a structural collapse of the glymphatic network in severe injury. The combined application of clinical markers and quantitative PVS metrics provides superior diagnostic accuracy compared to conventional MRI injury patterns. This objective approach complements clinical assessment and enhances risk stratification for neonates with HIE.

This study aimed to evaluate whether three-dimensional (3D) Black Bone imaging enhances diagnostic accuracy in detecting skull fractures in children with traumatic brain injury (TBI), using computed tomography (CT) as the reference standard. Data were collected between January 2022 and August 2024 from 50 pediatric TBI patients (27 boys, 23 girls; mean age: 4.76 ± 3.39 years) who underwent CT (gold standard) and conventional magnetic resonance imaging (MRI), with or without the Black Bone sequence, for fracture diagnosis. Patients were categorized by age (< 3 years, ≧3 years) and fracture type (linear, depressed, sutural disconnection, comminuted). The presence or absence of skull fracture was assessed using conventional MRI with and without Black Bone images. Conen’s kappa, McNemar’s test, area under curve (AUC), accuracy, sensitivity, negative predictive values (NPV) and positive predictive values (NPV) were employed to compare inter-reader agreement and fracture detection performance between image types. For all cases of skull fracture, conventional MRI with Black Bone images demonstrated an AUC of 0.947 (95

BACKGROUND:Neonatal hypoxic-ischemic encephalopathy (HIE) diagnosis is confounded by heterogeneous neural injury and metabolic dysfunction. Multi-pool chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) uniquely quantifies amide proton transfer, nuclear Overhauser enhancement, and magnetization transfer signals, providing multi-parametric assessment of HIE pathophysiology. OBJECTIVE:To investigate whether multi-pool CEST MRI can serve as a molecular-specific biomarker for histopathological alterations in HIE and assess its efficacy in grading disease severity. MATERIALS AND METHODS:This prospective study included 20 neonates with HIE and 42 age-matched controls undergoing 3.0-T CEST MRI. Imaging data were spatially normalized to a neonatal atlas for region-specific analysis (caudate, putamen, thalamus, pallidum, amygdala, hippocampus). Group differences in CEST signals (amide proton transfer, nuclear Overhauser enhancement, magnetization transfer) were analyzed via Wilcoxon tests, with diagnostic performance evaluated through receiver operating characteristic analysis. RESULTS:Compared to controls, HIE neonates showed significant reductions in amide proton transfer (bilateral putamen, right hippocampus/pallidum/amygdala, left thalamus/caudate), nuclear Overhauser enhancement (left thalamus/caudate/putamen), and magnetization transfer signals (bilateral thalamus/pallidum/putamen, left caudate; all P<0.05). Subgroup analysis revealed progressive metabolic decline: moderate-to-severe HIE exhibited further amide proton transfer reduction in the right thalamus, nuclear Overhauser enhancement decreases in bilateral hippocampus, and magnetization transfer decreases in left hippocampus/thalamus compared to mild cases (all P<0.05). Notably, conventional amide proton transfer-weighted imaging showed no significant changes, as the reduction in amide proton transfer signal was offset by a concurrent decrease in the nuclear Overhauser enhancement, highlighting the superiority of multi-pool analysis. Left hippocampal nuclear Overhauser enhancement demonstrated exceptional severity discrimination (area under curve (AUC)=0.96), while a multi-region integrated model achieved perfect staging accuracy (AUC=1.00). CONCLUSION:Multi-pool CEST MRI effectively captures histopathological changes in neonatal HIE, with left hippocampal nuclear Overhauser enhancement emerging as a precise biomarker for severity stratification. The combined dynamics of amide proton transfer, nuclear Overhauser enhancement, and magnetization transfer signals provide noninvasive insights into metabolic-pathological correlations, highlighting its transformative potential for early diagnosis and targeted therapeutic monitoring.

This study aimed to determine whether adding pointwise encoding time reduction with radial acquisition (PETRA) images to conventional magnetic resonance (MR) imaging improves the depiction and characterization of traumatic fractures in pediatric patients. Twenty-nine pediatric subjects with fractures and a control group of twenty individuals without fractures were included. Two independent observers assessed conventional MR, PETRA, and combined MRI + PETRA images, documenting the presence of fractures, bone fragments, callus formation, displacement, size, and angles of fractures. Diagnostic accuracy was higher for combined conventional MR with PETRA images than for conventional MR or PETRA alone in detecting fractures (area under curve (AUC): 0.86 for conventional MR, 0.97 for PETRA, 1.00 for combined), callus formation (AUC: 0.67 conventional MR, 0.82 PETRA, 0.86 combined), and bone fragments (AUC: 0.89 conventional MR, 0.96 PETRA, 0.97 combined). PETRA images improved agreement in detecting fractures, especially in the ulna/radius (κ = 0.46 conventional MR, 1.00 PETRA, 1.00 combined) and fibula/talus (κ = 0.42 conventional MR, 1.00 PETRA, 1.00 combined), compared to CT. PETRA also enhanced agreement in characterizing callus formation, bone fragments, displacement, size and fracture angles (intraclass correlation > 0.88 for all comparisons), compared to CT. Addition of PETRA images revealed that the differences in the measurements of fragment displacement, size, and fracture angle compared to CT, were not statistically significant (all p > 0.05). Adding PETRA images to conventional MR enhances diagnostic accuracy and reliability in detecting fractures among pediatric patients compared to conventional MR alone. Not applicable.

ObjectiveThe deep medullary veins (DMVs) can be evaluated using susceptibility-weighted imaging (SWI). This study aimed to apply radiomic analysis of the DMVs to evaluate brain injury in neonatal patients with hypoxic-ischemic encephalopathy (HIE) using SWI.MethodsThis study included brain magnetic resonance imaging of 190 infants with HIE and 89 controls. All neonates were born at full-term (37+ weeks gestation). To include the DMVs in the regions of interest, manual drawings were performed. A Rad-score was constructed using least absolute shrinkage and selection operator (LASSO) regression to identify the optimal radiomic features. Nomograms were constructed by combining the Rad-score with a clinically independent factor. Receiver operating characteristic curve analysis was applied to evaluate the performance of the different models. Clinical utility was evaluated using a decision curve analysis.ResultsThe combined nomogram model incorporating the Rad-score and clinical independent predictors, was better in predicting HIE (in the training cohort, the area under the curve was 0.97, and in the validation cohort, it was 0.95) and the neurologic outcomes after hypoxic-ischemic (in the training cohort, the area under the curve was 0.91, and in the validation cohort, it was 0.88).ConclusionBased on radiomic signatures and clinical indicators, we developed a combined nomogram model for evaluating neonatal brain injury associated with perinatal asphyxia.

目的:分析新生儿脑白质损伤累及深髓静脉的MRI 特征及演变.方法:回顾性分析 2015年-2021 年本院新生儿科 57 例严重脑白质损伤,其中深髓静脉受累组 19 例(早产儿 8 例、足月儿 11例),15 例行 1～8 次不等的MR复查,对比分析病灶分布特征、出血部位及演变.深髓静脉未受累组 38例(早产儿 12 例、足月儿 26 例),35 例行 1～6 次不等 MR 复查,对比深髓静脉受累组与深髓静脉未受累组脑软化灶形成情况.结果:早产儿生发基质/侧脑室旁白质出血发生率较足月儿高(P＜0.05),早产儿脑损伤评估为 4 等级者较足月儿高(P＜0.05),其余病灶发生部位足月儿与早产儿无明显差异,顶叶(15/19)、额叶(13/19)较多见.19 例患儿中 7 例在第 1 次MR检查发现侧脑室周围脑软化灶形成,7例随访患儿最后发展为脑软化灶形成,1 例在复查中无软化灶形成,仅见胶质增生.38 例深髓静脉未受累组中最后 12 例形成脑软化灶.结论:与足月儿相比,早产儿脑白质损伤伴有深髓静脉受累者侧脑室旁出血发生率更高且脑白质损伤程度更严重.相比无深髓静脉受累的严重脑白质损伤者,深髓静脉受累患儿更易形成脑软化灶.因此在新生儿脑白质损伤患儿中当深髓静脉异常时需警惕.

Neonatal subpial hemorrhage is a poorly understood type of intracranial hemorrhage. Herein, we reported on 34 neonates with subpial hemorrhages, focusing on the imaging features, clinical factors, and outcomes of this type of intracranial hemorrhage. This retrospective case series enrolled 34 neonates with subpial hemorrhages. We analyzed their magnetic resonance (MR) images, clinical manifestations, and prognoses. We categorized, for the first time, the MR images of patients with subpial hemorrhages into three imaging patterns; moreover, on the basis of a yin-yang sign, we added a sandwich sign, attaining an MR image feature that was easier to understand. MR Patterns A and B both have good prognoses, and most patients had normal clinical outcomes. Subpial hemorrhage in neonates may be diagnosed via imaging patterns. Recognizing this pattern of hemorrhage may help gain a better understanding of the associated risk factors.

Background No study has assessed normal magnetic resonance imaging (MRI) findings to predict potential brain injury in neonates with hypoxic–ischemic encephalopathy (HIE). Objective We aimed to evaluate the efficacy of MRI-based radiomics models of the basal ganglia, thalami and deep medullary veins to differentiate between HIE and the absence of MRI abnormalities in neonates. Materials and methods In this study, we included 38 full-term neonates with HIE and normal MRI findings and 89 normal neonates. Radiomics features were extracted from T1-weighted images, T2-weighted images, diffusion-weighted imaging and susceptibility-weighted imaging (SWI). The different models were evaluated using receiver operating characteristic curve analysis. Clinical utility was evaluated using decision curve analysis. Results The SWI model exhibited the best performance among the seven single-sequence models. For the training and validation cohorts, the area under the curves (AUCs) of the SWI model were 1.00 and 0.98, respectively. The combined nomogram model incorporating SWI Rad-scores and independent predictors of clinical characteristics was not able to distinguish HIE in patients without MRI abnormalities from the control group (AUC, 1.00). A high degree of fitting and favorable clinical utility was detected using the calibration curve with the Hosmer−Lemeshow test. Decision curve analysis was used for the SWI, clinical and combined nomogram models. The decision curve showed that the SWI and combined nomogram models had better predictive performance than the clinical model. Conclusions HIE can be detected in patients without MRI abnormalities using an MRI-based radiomics model. The SWI model performed better than the other models. Graphical Abstract

OBJECTIVE:This study aimed to apply radiomics analysis of the change of deep medullary veins (DMV) on susceptibility-weighted imaging (SWI), and to distinguish mild hypoxic-ischemic encephalopathy (HIE) from moderate-to-severe HIE in neonates.METHODS:A total of 190 neonates with HIE (24 mild HIE and 166 moderate-to-severe HIE) were included in this study. All of them were born at 37 gestational weeks or later. The DMVs were manually included in the regions of interest (ROI). For the purpose of identifying optimal radiomics features and to construct Rad-scores, 1316 features were extracted. LASSO regression was used to identify the optimal radiomics features. Using the Red-score and the clinical independent factor, a nomogram was constructed. In order to evaluate the performance of the different models, receiver operating characteristic (ROC) curve analysis was applied. Decision curve analysis (DCA) was implemented to evaluate the clinical utility.RESULTS:A total of 15 potential predictors were selected and contributed to Red-score construction. Compared with the radiomics model, the nomogram combined model incorporating Red-score and urea nitrogen did not better distinguish between the mild HIE and moderate-to-severe HIE group. For the training cohort, the AUC of the radiomics model and the combined nomogram model was 0.84 and 0.84. For the validation cohort, the AUC of the radiomics model and the combined nomogram model was 0.80 and 0.79, respectively. The addition of clinical characteristics to the nomogram failed to distinguish mild HIE from moderate-to-severe HIE group.CONCLUSION:We developed a radiomics model and combined nomogram model as an indicator to distinguish mild HIE from moderate-to-severe HIE group.

目的 观察儿童肌纤维瘤(病)影像学及临床表现.方法 回顾性分析16例经病理确诊肌纤维瘤(病)患儿的C T、M RI及临床资料,观察其特征性表现.结果 16例均见全身不同部位单发或多发浅表肿块,其中13例单发病灶多位于头面部、四肢,3例多发病灶均位于四肢和躯干且累及骨骼;肿块可呈正常肤色、红色或淡紫色,质硬,活动度差,多不伴疼痛、发热及皮温升高.平扫C T肿块呈混杂密度,实性部分呈稍低密度,11例(11/16,68.75％)病灶伴囊变,6例(6/16,37.50％)伴钙化;增强C T扫描,病灶多呈中、重度不均匀强化,周边多明显强化.M R平扫中肿块均表现为混杂信号;增强后病灶均呈不均匀强化,且周边强化明显.3例病变累及骨骼,影像学见骨质密度减低区/稍长T1长T2信号,边界清晰,无明显骨膜反应,增强后多呈中、高度强化.结论 肌纤维瘤(病)多见于2岁以下婴幼儿,多表现为头面部和四肢单发、无痛性结节,可呈正常肤色、红色或淡紫色,亦可多发并累及骨骼;C T/M RI可呈密度/信号不均的实性肿块,血供丰富,多伴囊变,增强后多呈中、高度强化,周边强化明显.

目的:探讨儿童自身免疫性胶质纤维酸性蛋白(Glial fibrillary acidic protein,GFAP)星形细胞病的头颅MRI特征及临床表现.方法:回顾性分析11例儿童自身免疫性GFAP星形细胞病患儿的临床及影像学改变.结果:主要临床症状为发热(3例)、头痛(3例)、头晕(1例)、嗜睡(2例)、精神行为异常(2例).脑内异常信号患者9例,其中5例表现双侧基底节、丘脑、侧脑室周围及皮层下脑白质内多发对称性线样、条状异常信号,于T2WI、FLAIR序列呈高信号,仅2例出现脑白质放射状强化,最常见的是软脑膜异常强化(5例).结论:目前儿童自身免疫性GFAP星形细胞病头颅MRI表现具有一定特征性.

OBJECTIVE:To describe the clinical features of autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy in children.METHOD:Data from 11 pediatric patients with autoimmune GFAP astrocytopathy were retrospectively analyzed.RESULTS:All of the patients showed encephalitis and meningoencephalitis or meningoencephalomyelitis with or without myelitis. 45.4% of the patients had fever, 27.3% headaches, 18.2% dizziness, 18.2% drowsiness, and 18.2% mental disorders. Cerebrospinal fluid (CSF) was detected in all patients. The white blood cell counts (WBC) (90.9%), lactic dehydrogenase levels (72.7%), protein level (36.4%), and adenosine deaminase activity (ADA) level (27.3%) were elevated, and the CSF glucose levels (72.7%) were slightly reduced. Nine patients (90%) were found to have brain abnormalities, of which five (50.0%) patients had abnormal symmetrical laminar patterns or line patterns hyperintensity lesions on T2-weighted and fluid-attenuated inversion recovery (FLAIR) images in the basal ganglia, hypothalamus, subcortical white matter and periventricular white matter. The linear radial enhancement pattern of the cerebral white matter was only seen in two patients, with the most common being abnormal enhancement of leptomeninges (50%). Five patients had longitudinally extensive spinal cord lesions.CONCLUSION:The findings of pediatric patients with autoimmune GFAP astrocytopathy are different from previous reports.

目的:回顾性分析12例自身免疫性胶质纤维酸性蛋白星形细胞病(autoimmune glial fibrillary acidic protein astrocytopathy，GFAP-A)患儿的临床资料，总结其临床特点及治疗经验。方法:回顾性分析2020年2月至2022年4月湖南省儿童医院重症医学科诊断的12例GFAP-A患儿病例资料，对患儿的临床表现、实验室检查、神经影像学、脑电图、治疗方案及预后等情况进行分析。结果:12例GFAP-A患儿平均发病年龄6.5岁，男女比例3∶1。主要以发热(10例，83.3%)为前驱症状，临床表现为认知或意识水平下降9例(75.0%)、头痛或头晕6例(50.0%)、呼吸衰竭6例(50.0%)、癫痫发作7例(58.3%)等。实验室检查脑脊液呈炎性改变10例(83.3%)，脑脊液、血清GFAP-IgG抗体阳性分别为8例(66.7%)、9例(75.0%)，合并抗体2例(16.7%)。头颅MRI为颅内多发性病灶8例(66.7%)，垂直于脑室周围线状放射状样强化1例(8.3%)，脊髓长节段受累伴强化4例(33.3%)。录像脑电图背景节律慢化7例(58.3%)。12例患儿急性期均给予大剂量甲基泼尼松龙冲击或联合丙种球蛋白等治疗，10例(83.3%)好转，1例症状反复，1例因合并多系统感染死亡。结论:儿童GFAP-A临床表现为急性或亚急性脑膜脑炎伴或不伴脊髓炎综合征，脑脊液或血清抗体阳性，特异性MRI改变，大部分患儿经早期激素及免疫治疗预后良好。

[目的]探讨免疫正常的侵袭性肺曲霉菌病的CT特征.[方法]回顾性分析临床20例免疫正常的侵袭性肺曲霉菌病患儿的临床资料,分析其CT特征.[结果]20例确诊的免疫正常的侵袭性肺曲霉菌病患儿中,20例CT均可见异常改变,表现为斑片影、实变、结节、团块影等.肺实变75％(15/20),多沿肺段分布,呈节段性肺实变;25％(5/20)表现为斑片状渗出病灶,无实变.结节多发,占50％(10/20),大小不一,平均直径约4(3.0～7.0)m m;典型支气管黏液栓形成率为10％(2/20),结节周围晕征多见,约为80％(8/10).支气管呈中心性扩张,支气管扩张25％(5/20),中心性扩张占80％(4/5);支气管管壁增厚30％(6/20),其中合并支气管扩张5例,发生率为25％ ～30％;少数病例可见肺门区淋巴结肿大15％(3/20);无钙化.所有病例中均无空气新月征形成.[结论]免疫功能的侵袭性肺曲霉菌病CT特征有结节伴晕征、实变、不同程度支气管扩张、管壁中心性增厚、支气管黏液栓,临床上可根据上述CT特征结合临床诊断侵袭性肺曲霉菌病.

目的 分析儿童抗N-甲基-D-天冬氨酸(NMDA)受体脑炎的头颅MRI表现及发病机制.资料与方法 回顾性分析行头颅MRI平扫及增强扫描的34例抗NMDA受体脑炎患儿的头颅MRI资料,总结其影像学特征.结果 34例患儿中,17例MRI表现异常.14例为多发病灶,3例为单发病灶.病灶分布:额叶10例,顶叶10例,颞叶9例,枕叶5例,岛叶4例,基底节4例,丘脑7例,胼胝体1例,脑干2例,小脑2例.根据累及部位可分为4型:皮层灰质受累型6例,皮层灰质及皮层下白质受累型2例,深部神经核团受累型2例,混合型7例.15例病灶形态多呈脑沟样或团块状,受累皮层灰质显示肿胀.病灶在T1WI序列呈稍低信号,T2WI、FLAIR序列呈稍高信号,其中6例有异常强化.结论 抗NMDA受体脑炎影像学表现各异,可仅累及皮层灰质、灰质下白质,也可累及深部神经核团,甚至表现为多部位混合受累.

目的 探讨儿童朗格汉斯细胞组织细胞增生症(LCH)累及肝脏的CT、MRI表现.方法 回顾性分析确诊为LCH侵犯肝脏的22例患儿的CT及MRI表现.结果 22例患儿均表现肝脏肿大.20例Glisson鞘增宽及汇管区轨道征、晕征,其中16例CT呈低密度,5例CT增强扫描呈轻、中度强化,4例MRI表现为T2WI高信号,2例MRI增强后轻度强化.14例表现为肝内多发结节,直径约0.51～2.35 cm,其中10例沿门静脉分布、4例呈弥漫性分布;11例CT呈低密度,5例CT增强呈轻、中度强化,3例T1WI呈低信号、T2WI呈高信号,2例MR增强扫描轻度强化,较大结节呈环形强化.8例肝内胆管呈节段性狭窄及不同程度扩张.结论 儿童LCH累及肝脏的CT、MRI表现具有一定特征性.

目的:分析儿童抗N-甲基-D-天冬氨酸(N-methyl-D-aspartate,NMDA)受体脑炎头颅MRI表现与临床特征.方法:对34例抗NMDA受体脑炎患儿进行影像资料与临床资料综合分析,并在入院时、入院治疗6月后全部进行改良的疾病严重程度评分(mRS).结果:34例患儿中17例MRI表现异常,MRI表现异常者T2WI、FLAIR序列呈高信号.异常信号灶多分布于颞叶、岛叶、额顶枕叶,部分病灶亦可见于基底节、丘脑、胼胝体及脑干、小脑,其中6例伴有脑膜和/或脑实质病灶明显强化.首发症状癫痫位于第一位(74％),其次精神行为异常(35％)、发热(32％)、运动障碍(17.6％)、意识障碍(17.6％).癫痫发作、精神行为异常、发热、运动障碍、意识障碍、单纯疱疹病毒感染患儿MRI表现正常者与MRI表现异常者差异无统计学意义(P＞0.05),34例患儿中MRI表现正常与MRI表现异常的年龄分布差异无统计学意义(P＞0.05).入院mRS评分,MRI表现正常者与MRI表现异常者差异无统计学意义(P＞0.05),治疗6月后mRS评分,MRI表现正常者平均评分低于MRI表现异常者,差异有统计学意义(P＜0.05).结论:儿童抗NMDA抗体受体脑炎MRI表现正常者预后较好、治愈率高,MRI异常者常提示预后较差.

Objective To investigate the application value of magnetic resonance diffusion tensor imaging (DTI) in auditory pathway of sensorineural hearing loss (SNHL) infants caused by cytomegalovirus (CMV) infection.Methods Thirtyone SNHL infants caused by CMV infections were included,and were divided into bilateral hearing loss (BPHL;n=13) group and unilateral hearing impairment (UPHL;n=18) group (including damaged side [lpsi subgroup] and the undamaged side [contrast subgroup]).Thirty-one infants without hearing loss as control group.The fractional anisotropy (FA),the mean diffusivity (MD),the axial diffusivity (AD) and the radial diffusivity (RD) of bilateral inferior colliculus (IC)and lateral lemniscus (LL) were obtained with DTI technique.The statistical analysis was performed.Results Compared with the control group,the FA value reduced and the RD value increased at LL and IC in the BPHL group (all P＜0.001).Compared with the contrast subgroup,the FA value reduced and the RD value increased at IC and LL in lpsi subgroup (all P＜0.001).Compared with the control group,the FA value reduced at LL in the lpsi subgroup,and FA values reduced and RD value increased at IC (all P＜0.001).Compared with the contrast subgroup,the FA value reduced and RD value increased at LL,and RD value increased at IC in the BPHL group (all P＜0.001).The FA value at IC was negatively correlated with auditory threshold (r=-0.966,P＜0.001).No matter in IC or in LL,the MD and AD had no statistical differences (all P＞0.05).Conclusion White matter of auditory pathway of SNHL infant caused by CMV infection is obviously altered,suggesting white matter myelination or myelin dysplasia.

目的 探讨MRI优化的三维容积内插快速扰相梯度回波(3D-Radial-VIBE)序列在胎儿神经系统检查中的应用价值.方法 收集超声诊断或疑似胎儿颅脑异常的中晚期妊娠妇女20名,对其分别行二维快速小角度激励扰相梯度回波序列(2D-FLASH)和3D-Radial-VIBE序列扫描,然后对2个序列图像显示的胎儿颅脑26个正常解剖结构分别进行评分,并进行统计学分析.结果 26个胎儿颅脑解剖结构中,22个结构的3D-Radial-VIBE序列与2D-FLASH序列评分的差异有统计学意义(P均＜0.05).与2D-FLASH序列比较,3D-Radial-VIBE序列运动伪影较小,胎头、胎盘、内脏等均显示较好,尤其可清晰显示胎头结构以及灰白质、髓鞘化过程.3D-Radial-VIBE序列示20胎正常颅后窝静脉窦区均呈低信号,而2D-FLASH示15胎呈高信号,假阳性率为75.00％(15/20).与2D-FLASH序列比较,3D-Radial-VIBE序列显示的出血灶更清晰.3D-Radial-VIBE序列显示顶叶灰质与白质的信号对比度、颞叶灰质与白质的信号对比度及颞叶灰质与板障的信号对比度均高于2D-FLASH序列(P均＜0.05).结论 3D-Radial-VIBE序列扫描过程中无需屏气,抗运动伪影效果好,对神经核团、髓鞘化过程及出血灶的显示具有明显优势.