Показано, что контроль качества лекарственных средств на основе гидроксиэтилированного крахмала можно проводить с помощью абсолютного метода анализа молекулярно-массового распределения — эксклюзионной хроматографии с детектором многоуглового лазерного светорассеяния. В работе приведены результаты, необходимые для обоснования включения описанной методики в отечественные нормативные документы на гидроксиэтилированный крахмал.

The content and molecular weight of polymer fraction in commercial albumin preparations from various manufacturers were evaluated by multiple angular laser photodiffusion detector. The results (percentage of high-molecular fraction) were compared with values obtained by the European Pharmacopoeia method. The polymer concentrations increased as a result of thermal inactivation of albumin.

Oligo(hexamethyleneguanidine) (OHMG) hydrochloride samples with various molecular weights synthesized from hexamethylenediamine and guanidine hydrochloride were characterized by 13C NMR, ultracentrifugation, and capillary viscosimetry techniques. It was found that OHMG hydrochloride has 0.16 - 1.08 branching points per molecule. Number-average molecular weights Mn and weight-average molecular weights Mw were calculated from 13C NMR and ultracentrifugation data. A comparative analysis of these characteristics shows that the synthesized oligomers have a wide molecular-weight distribution (Mw/Mn = 5.4 - 9.3).