Objective To investigate preventive effect of uneven constant magnetic field on learning and memory impairment induced by hypobaric hypoxia in mice. Method Seventy two mice were divided into control group, hypoxia group(8 000 m,30 min), magnetic field pole N(15 days)+hypoxia group and magnetic field pole S(15 days)+ hypoxia group. The step through test and independent activity were used to observe effect of uneven constant magnetic field pole N and S on learning and memory impairment induced by hypobaric hypoxia . The histomorphological changes of brain cortex were observed by electron microscope Results ①The results of step through test indicated that the mistakes of magnetic field pole N+ hypoxia group and magnetic field pole S+ hypoxia group were less than that of hypoxia group( P0.01,P0.05 ) and the escape latency was longer than that of hypoxia group( P0.01,P0.05 ). Compared with the magnetic field pole S+ hypoxia group, the escape latency of the magnetic field pole N + hypoxia group was longer( P 0.05).②The independent activity of hypoxia group rats was significantly less than that of other 3 groups ( P 0.01).③Uneven constant magnetic field could alleviate the deformation of neuronal nucleus and change of nuclear membrane structure induced by hypoxia. Conclusions Staying in constant magnetic field especially pole N possesses preventive effect against impairment of brain induced by acute hypoxia.

AIM: To study the effects of hypothermia and hypoxia on neuropeptides and immune function. METHODS: Acute hypobaric hypoxia experiment in chambers at 22, 10 or 5℃ was carried out in 48 healthy Kunming mice. Plasma levels of β EP and L EK were observed. The splenocyte proliferation induced by ConA or LPS and the activities of IL 1 and IL 2 by mice thymocyte proliferation. were assayed with MTT method. RESULTS: Plasmaβ EP and L EK levels (ng·L -1 ) increased more significantly in 10℃ and 7 km environment than those at room temperature (395±66 vs 271±37, P 0.01). Plasma β EP level in 5℃ and 7 km environment decreased more significantly than that at room temperature (283±59 vs 271±37, P 0.01). T and B lymphocyte proliferation (MBq) decreased more in 10℃ and 7 km environment than that in the room temperature control (62.5±6.8 vs 2.1±0.2, 58.8±8.1 vs 30.6±3.9, P 0.01). IL 1 decreased more under 5℃ and 7 km than that under room temperature control (1.28±0.32 vs 1.51 ±0.31, P 0.01). CONCLUSION: Increased contents of β EP in 7 km and 10℃ environment inhibited mice immune function, and decreased contents of plasma β EP in 7 km and 5℃ environment inhibited mice immune function lightly.

目的:探讨非均匀恒磁场N极、S极对急性低压缺氧引起的学习记忆障碍是否有改善作用.方法:48只小鼠分为空白对照组、缺氧组、磁场N极+缺氧组和磁场S极+缺氧组.采用避暗实验法和自主活动法进行观察.结果:(1)避暗实验表明,磁场N极+缺氧组、磁场S极+缺氧组的累积错误次数(M值)分别为2.42±1.08与2.50±1.17;逃避潜伏期(EL值)分别为(71.08±19.55)s与(53.00±19.75)s,缺氧组M值为(3.58±1.08)次,EL值为(32.50±11.60)s,则表明记忆成绩M值减少(P＜0.01,P＜0.05),EL值延长(P＜0.01,P＜0.05),且磁场N极+缺氧组的EL值较磁场S极+缺氧组的EL值延长(P＜0.05).(2)动物自主活动测定表明,缺氧组、空白对照组、磁场N极+缺氧组和磁场S极+缺氧组的自主活动次数分别为104±22.07、185±41.15、187±37.16、182±29.13,缺氧组的明显减少(P＜0.05),而经磁场处理的两组已恢复到正常水平.结论:非均匀恒磁场的预防性治疗,可改善由低压缺氧造成的记忆功能损害,且以N极作用更为明显.

目的 观察急性高空缺氧对D-半乳糖亚急性衰老小鼠免疫功能的影响。方法 将D-半乳糖亚急性衰老小鼠放入小动物低压舱内，以20m/s速度上升到7000m停留1h，停留后以20m/s速度降至地面。然后对鼠的脾淋巴细胞增殖反应、IL-1、IL-2及IL-3活性进行检测。结果 D-半乳糖亚急性衰老小鼠与其它各组鼠之间的脾淋巴细胞增殖反应有显著差异(P＜0.01)；D-半乳糖亚急性衰老小鼠与正常小鼠IL-3活性比较显著升高(P＜0.01)，IL-1、IL-2活性无显著差异；在7000m高度，正常鼠与地面比较IL-1及IL-2显著增高(P＜0.01)，D-半乳糖亚急性衰老小鼠与地面比较IL-2显著增高(P＜0.01)。结论 7000m急性高空缺氧致使正常及D-半乳糖亚急性衰老小鼠免疫功能的变化。D-半乳糖亚急性衰老小鼠中，小鼠脾淋巴细胞增殖反应、IL-2增高。

目的:探讨环境温度变化对低压、缺氧动物体温的影响,为高空实验中条件的选择提供科学依据.方法:在自制小动物温控低压舱内,模拟升空上升、下降速度为30 m·s-1,测量大鼠在10℃及20℃条件下,平地、3 000 m及5 000 m停留时的体温.结果:在模拟平地、海拔3 000m和海拔5 000 m的不同高度下,10℃组大鼠体温明显低于20℃组(P＜0.05或P＜0.01);随着高度上升,体温下降的绝对值增大.结论:模拟平地、海拔3 000 m和海拔5 000m实验条件下,在同一高度下,实验大鼠的体温随着外界温度的降低,体温降低;随着高度上升,由于低压缺氧引起外周血管扩张,致使体温降低更加明显.

素质教育是本世纪教育的主题,教育工作者需以学生为主体,结合素质形成和发展的基本规律来提高学生的整体素质.

目的探讨音频电对急性低压缺氧引起学习记忆障碍的保护作用.方法采用小鼠避暗实验法及自主活动法,观察音频电疗法对急性低压缺氧小鼠学习记忆功能的影响.结果音频电及音频电+低压缺氧组与相应的对照组比较,错误次数(M)明显减少,潜伏期(EL)显著延长;音频电+低压缺氧组与模型组比较,自主活动增加.结论音频电预防性治疗可改善由低压缺氧造成的记忆功能损害,并对急性缺氧所致的中枢抑制有改善作用.

目的：探讨急性轻、中度缺氧对智力的影响。方法：对19名非智力、心理因素的航校停飞学员，在地面分别吸入13．6％、10．5％浓度的低氧混合气30 s后作简便运算。结果：与吸入空气相比，吸入13．6％低氧混合气时，计算时间延长(P＜0．01)，正确率降低(P＜0．05)；吸入10．5％低氧混合气时，反应时间及正确率与吸入13．6％低氧混合气时均有显著差异(P＜0．01)。结论：急性轻、中度缺氧时，智力呈进行性减退。

目的研究低温和低压缺氧复合因素对大鼠脑垂体和血浆阿黑皮素原衍生肽含量的影响. 方法采用56只健康成熟的雄性Wistar大鼠,分别在10℃和20℃条件下模拟上升至3 km和5 km高度,设25℃室温地面对照组.观察大鼠脑垂体和血浆阿黑皮素原衍生肽含量的变化. 结果 20℃环境中,5 km组血浆β-EP和ACTH含量显著高于地面对照组和3 km组(P<0.01),脑垂体β-EP的含量显著降低(P<0.01);10℃环境中随高度升高,血浆β-EP含量显著降低(P<0.01),脑垂体β-EP的含量显著升高(P<0.01),5 km组血浆ACTH较地面对照组显著降低(P<0.01). 20℃地面对照及各高度组血浆ACTH含量和20℃ 5 km组血浆β-EP含量均显著高于10℃相应高度组(P<0.01). 结论 20℃条件下随着缺氧程度加深,血浆β-EP和ACTH升高;10℃条件下血浆β-EP降低,低压缺氧条件下,随着环境温度降低,血浆ACTH含量下降,将对体温调节产生重要影响.