2020年的诺贝尔生理学或医学奖授予了在发现丙肝病毒（HCV）方面作出突出贡献的哈维 · 阿尔特（Harvey J. Alter）、迈克尔 · 霍顿（Michael Houghton）和查尔斯 · 赖斯（Charles M. Rice）。然而，从1989年霍顿捕获 HCV 到 1997 年赖斯证明 HCV 能引发肝炎，间隔了 8 年时间。这看似一步之遥的距离何以耗时如此之久？文章通过回顾文献，对这一时期的研究脉络进行了梳理，明确了包括赖斯团队在内的不同研究者对于推进 HCV 相关认识所作的具体贡献。同时，针对研究过程中的两个关键节点——病毒 RNA 基因组3′末端的准确测序和感染性分子克隆的建立，文章从技术储备、路径依赖和目标定位的角度分析了赖斯团队为何能在科学研究竞争中拔得头筹。

Objective This study examined the curriculum of the Biomedical English Program of Peking University Health Science Center and identified issues in its design,in an attempt to inform improvement efforts in this regard.Methods A questionnaire survey was conducted to 92 undergraduates enrolled to this program between 2010 and 2012,where the students were required to rate the perceived importance of all the 93 courses in the program and give feedback on the current curriculum and curriculum system.Results Medical courses were perceived to be significantly less important than language courses [(3.76±0.20) vs (4.15±0.34),F=24.42,P＜0.001].The students suggested that issues existed in the current curriculum concerning scope,depth,transition and term distribution;that the ratios of compulsory and medical courses were too large;and that there was a lack of cohesion between medical and language courses.Conclusions It is necessary to adjust the curriculum by consolidating medical courses,increasing elective courses on the language side,fostering greater cohesion of medical science and language training,and creating online courses.