目的 探讨基于行为转变理论的饮食健康教育在脊柱转移瘤术后患者中的应用效果.方法 选取2022年 1 月-2023 年 1 月医院收治的 72 名脊柱转移瘤术后患者作为研究对象,根据组间均衡可比原则分为对照组和观察组,每组各 36 例.对照组行常规护理,观察组在对照组基础上实施基于行为转变理论的饮食健康教育,比较两组患者营养状况、自护能力以及生活质量的改善情况.结果 饮食健康教育干预前,两组患者血清白蛋白(ALB)、转铁蛋白(TRF)、前白蛋白(PA)等3项营养状况指标以及患者自护能力评分和生活质量评分比较,差异均无统计学意义(P＞0.05).饮食护理干预后,两组患者ALB、TRF、PA等营养状况指标,自护能力评分和生活质量评分均明显升高,且观察组患者营养状况指标水平和自护能力、生活质量评分均高于对照组,差异均有统计学意义(P＜0.05).结论 基于行为转变理论的饮食健康教育在脊柱转移瘤术后患者中的应用效果较好,可改善患者营养状况,提高患者自护能力和生活质量.

目的 观察分析综合护理模式在球囊阻断下骶骨肿瘤切除术患者中的应用效果.方法 选择医院2021年 1 月-2022 年 12 月收治的 100 例骶骨肿瘤患者作为研究对象,按照组间性别、年龄等基线资料均衡可比的原则将其分为对照组和观察组,每组 50 例.对照组按照常规护理标准实施护理,观察组开展综合护理.比较两组患者干预前、后下肢功能恢复状况及治疗期间并发症发生率.结果 综合护理模式干预后,观察组患者并发症发生率为 2.00%,显著低于对照组的 18.00%,差异有统计学意义(P<0.05).综合护理模式干预前,两组患者下肢功能恢复评分比较,差异无统计学意义(P>0.05);综合护理模式干预 7d后,两组患者下肢功能恢复评分均升高,但观察组高于对照组,差异有统计学意义(P<0.05).结论 综合护理模式在球囊阻断下骶骨肿瘤切除术患者中的应用,可有效预防术后并发症发生,促进患者下肢功能恢复.

BACKGROUND:The increased inflammation is closely correlated with post-operative delirium (POD). Mesencephalic astrocyte-derived neurotrophic factor (MANF) shows protective effect on inflammatory diseases. However, the relationship between MANF and POD is still undefined. This study aimed to explore the potential effect of MANF on POD.METHODS:Pre- and post-operative levels of MANF and inflammatory cytokines were measured in serum from POD and non-POD patients by ELISA, as well as endogenous MANF in serum from healthy individuals with different ages. Endogenous MANF in mice brain from different ages was also measured. Abdominal surgery was performed for POD mice model. POD-like behavior changes in mice were evaluated using buried food test, open field test and Y maze test.RESULTS:Endogenous MANF was decreased in age-dependent manner in both humans and mice. The pre-operative level of MANF in serum from POD patients was lower compared with that in non-POD patients (p=0.016). MANF increase in serum after surgery was less in POD patients than that in non-POD patients (p<0.001). In mice, recombinant human MANF reversed the surgery-induced elongation of latency to eat food, increase in latency to center and increase in time in center in open field test, and also increase in duration in novel arm in Y maze test. In addition, MANF inhibited surgery-induced inflammation, microglial activation and M1 polarization in mice.CONCLUSION:The relative low MANF level may contribute to POD in the elderly. MANF has a protective role against POD-like behavior changes in mice.

目的:分析总结腹主动脉球囊阻断技术在骶骨、骨盆肿瘤切除手术中应用的临床效果、球囊相关并发症及围手术期护理要点.方法:对20例患者进行围手术期护理评估、出血量、深静脉血栓(DVT)形成、手术时间、大小便及下肢功能、伤口及球囊置入相关并发症等资料进行观测分析.结果:20例患者均在腹主动脉球囊阻断下顺利完成手术.通过手术治疗及良好的围手术期康复护理,疗效满意,无护理及球囊阻断相关并发症发生.结论:腹主动脉球囊阻断是安全有效的术中控制出血的方式,良好的围手术期康复护理对减少并发症,提高疗效有着重要作用.