本文旨在探讨公立医院如何通过自媒体平台提升医学科普的传播效果。通过分析医学漫画科普的积极作用、现状问题和相应策略，我们希望为公立医院提供有力的指导，以更好地满足公众对健康信息的需求，提高医疗科普的传播效率。

室内色彩设计越来越得到重视.色彩设计能够直接地影响人们的身体和情绪.对于色彩在商业过程当中的作用,已经有色彩营销学的专业学科进行研究和设计.在医疗环境设计中,色彩也发挥着极为隐秘的作用.合理的色彩设计,能够让病人和医生产生良好的情绪,甚至会让病人病情加速好转,实现身体的康复.正是因为医疗环境中的色彩设计有如此重要的功能和作用,我们才着眼于色彩设计的基础作用和色彩设计的基本原则,探讨在医疗环境中需要进行的合理色彩设计模式,以求能够让医院通过科学的色彩设计,降低对病人的精神刺激和身体刺激,为病人创造一个良好的养病环境.

在21世纪开放的、动态的、多元的文化背景下,跨界混搭已成为一种潮流.艺术在变化中求生存,其内容、形式与材质等都有了新的探索,所有人都渴望打破传统观念的束缚,再加上多种艺术形式及流派的影响,混搭艺术就此兴起.这在某种程度上是一种"嫁接",不仅是为了达到新的艺术效果,也是为了给观众带来与众不同的视听体验.文章提出当代艺术发展的现状,源于艺术家对于个性的更为强烈的展现、对于自我精神展现的强烈渴望,在艺术创作中,艺术家们不再拘于单一的形式,而是寻求更为多样的表现手法,以更为丰富的形式和语言去表达.跨界混搭正是一种新型的创作方式,不受形式、内容、文化等的限制,它们自由地组合在一起,形成一种新的视觉效果.艺术在这种广阔的创作空间和语言里,表达出更丰富的情感和精神状态.

Objective To observe the effects of recombinant human erythropoietin(rHuEPO) in hippocampal neurons of status epilepticus (SE) SD rats kildled by Pentylenetetrazol(PTZ), and the expression changes of Bax post the application of phosphatidyl inositol 3-kinase(PI3K) inhibitor LY294002, then discuss the possible mechanisms of rHuEPO.Method The SE rats kindled by the PTZ were randomly divided into normal control group (normal saline, NS), PTZ group (PTZ+NS), rHuEPO group (PTZ+rHuEPO), LY294002 group (PTZ+LY294002+rHuEPO), LY294002 solvent dimethyl sulfoxide(DMSO) control group (rHuEPO+PTZ+DMSO). The behavior changes and electroencephalogram(EEG) recording of rats were detected; The apoptosis of hippocampal neurons were detected by TUNEL method; The expression of phosphorylation protein kinase B(p-PKB/p-Akt) and Bax were detected by immunohistochemistry method; the expression of BaxmRNA in hippocampal neurons of rats were detected through reverse transcription polymerase chain reaction (RT-PCR) method; The expression of Akt, p-Akt and Bax protein in hippocampal neurons of rats were detected through Western blot method.Results rHuEPO can promote the he expression of p-Akt protein while down-regulate the expression of Bax protein and play a neuroprotective role. The expression of Bax protein and BaxmRNA in hippocampus increased while the p-Akt decreased compared with that in rHuEPO group post the application of PI3K inhibitor LY294002, which decreased the protective effects of rHuEPO and the difference was statistical significant.Conclusion The PI3K/Akt signaling pathway is one of the pathways through that rHuEPO play neuroprotective effects and testified from the two aspects of positive and negative. rHuEPO regulates the expression of mitochondrial apoptotic pathway related factor Bax to inhibit apoptosis and promote neuronal survival.

Objective To observe the effects of recombinant human erythropoietin (rHuEPO) in hippocampal neurons of status epilepticus (SE) SD rats kindled by Pentylenetetrazol(PTZ), and the changes of aspartate specific cysteine protease-9 (Caspase-9) post the application of phosphatidyl inositol 3-kinase(PI3K) inhibitor LY294002, then to provide laboratory basis for rHuEPO in epilepsy diagnosis and treatment.Method The SE rats kindled by the PTZ were randomly divided into normal control group (normal saline, NS), PTZ group (PTZ+NS), rHuEPO group(PTZ+rHuEPO), LY294002 group(PTZ+LY294002+rHuEPO), LY294002 solvent dimethyl sulfoxide (DMSO) control group(rHuEPO+PTZ+DMSO). The behavior changes and electroencephalogram (EEG) recording of rats were detected; The apoptosis of hippocampal neurons were detected by TUNEL method; The expression phosphorylation protein kinase B(p-PKB/, p-Akt) and Caspase-9 were detected by immunohistochemistryn method; the expression of Caspase-9mRNA in hippocampal neurons of rats were detected through reverse transcription polymerase chain reaction (RT-PCR) method; The expression of Akt, p-Akt and Caspase-9 protein in hippocampal neurons of rats were detected through Western blot method.Results rHuEPO can down-regulate the expression of Caspase-9 and play a neuroprotective role. The expression of Caspase-9 protein and Caspase-9mRNA in hippocampus increased compared with that in rHuEPO group post the application of PI3K inhibitor LY294002, which decreased the protective effects of rHuEPO and the difference was statistical significant.Conclusion The PI3K/Akt signaling pathway is one of the pathways through that rHuEPO play neuroprotective effects and testified from the two aspects of positive and negative. rHuEPO regulates the expression of mitochondrial apoptotic pathway related factor Caspase-9 to inhibit apoptosis and promote neuronal survival.

Objective To observe the hippocampal neuron damage of status epilepticus ( SE) SD rats kindled by Pentylenetetrazol ( PTZ) ,and the changes of neurons apoptosis and the expression changes of Bad 、Bcl-2 post the application of recombinant human erythropoietin (rHuEpo) and phosphatidyl inositol 3-kinase(PI3K) inhibitor LY294002,then discuss the possible mechanisms of rHuEpo furtherly .Methods The SE rats kindled by the PTZ were randomly divided into nor-mal control group (normal saline,NS),model group (PTZ+NS),rHuEpo treated group (PTZ+rHuEpo),LY294002 trea-ted group(PTZ+LY294002+rHuEpo),LY294002 control group (rHuEpo+PTZ+DMSO).The apoptosis of hippocampal neurons were detected by TUNEL method;The positive expression neurons of phosphorylation protein kinase B ( p-Akt)、Bcl-2 and Bad were detected by immunohistochemistry SP method;The expression of Bcl-2 mRNA、Bad mRNA in hippocampal neurons of each group of rats were detected through reverse transcription polymerase chain reaction ( RT-PCR) method;The expression of p-Akt and Bcl-2、Bad protein in hippocampal neurons of each group of rats were detected through Western blot method.Results rHuEpo can promote the expression of p-Akt、 Bcl-2 protein and Bcl-2 mRNA while down-regulate the expression of Bad protein and Bad mRNA and play a neuroprotective role .The expression of Bad protein and Bad mRNA in hippocampus increased significantly while the p-Akt、Bcl-2、Bcl-2 mRNA decreased significantly compared with that in rHuEpo treated group post the application of PI 3K inhibitor LY294002,which decreased the protective effects of rHuEpo and the difference was statistical significant .Conclusion From two aspects of positive and negative hints rHuEpo anti-apoptotic effect may through the impact of PI 3K/Akt signal pathway ,thus mediate the expression level of Bcl-2 and Bad pro-tein in the mitochondrial pathway of apoptosis ,finally achieve the neuroprotective effect against injury of status epilepticus apoptosis.