We aimed to analyze the composition of urinary calculi and its correlations with blood lipids such as triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Three hundred patients with urinary calculi treated from January 2020 to July 2021 were selected retrospectively into a urinary calculi group, while three hundred healthy individuals who received physical examination in our hospital during the same period were enrolled in a control group. Using the Spearman correlation analysis, we investigated the correlation between the composition of urinary calculi and dyslipidemia and explored the factors affecting urinary calculi through multivariate logistic regression analysis. The serum levels of TG and TC were significantly higher (p<0.05), the serum HDLC level was significantly lower (p<0.05), while the serum LDL-C level displayed no significant difference (p>0.05) in the urinary calculi group compared with those in the control group. The proportion of uric acid calculi was significantly higher in urinary calculi patients with dyslipidemia than that in those with normal blood lipids (p<0.05). However, no significant difference was observed in the proportions of infectious calculi and calcium calculi between urinary calculi patients with dyslipidemia and those with normal blood lipids (p>0.05). Dyslipidemia was positively correlated with uric acid calculi (p<0.05) but not associated with infectious calculi or calcium calculi (p>0.05). TG was a risk factor for urinary calculi (p<0.05). The formation of urinary calculi is closely associated with blood lipid levels. Dyslipidemia, especially hypertriglyceridemia, can easily induce the formation of uric acid calculi.

目的 探讨肾虚育精方对肾精亏虚少弱精子症小鼠模型精子DNA损害及生精细胞凋亡的干预效果.方法 通过房劳联合惊恐的伤肾法复制肾精亏虚少弱精子症小鼠模型.动物实验分为正常组、模型组、五子衍宗丸组、肾虚育精方组四组,每组10只.按实验要求饲养父代小鼠以及子代小鼠后,予以取材.采用流式细胞术、Western blot依次检测父代小鼠的睾丸组织病理损伤、生精细胞凋亡、睾丸组织内Bcl-2/Bax的表达;血球计数法测定子代小鼠附睾内的精子数量.结果 与正常组相比,模型组父代小鼠生精细胞凋亡率、睾丸组织Bax的表达量明显升高,Bcl-2的表达量明显下降,子代小鼠附睾内精子浓度明显减少,差异具有统计学意义(P<0.05).与模型组相比,肾虚育精方组和五子衍宗丸组的生精细胞数量有所增加,生精细胞凋亡率、父代睾丸组织Bax的表达量明显下降,Bcl-2的表达量明显升高,子代小鼠附睾内精子浓度明显增加,差异具有统计学意义(P<0.05).结论 肾虚育精方可通过调节Bcl-2/Bax蛋白的表达,降低肾精亏虚少弱精子症小鼠生精细胞的凋亡率.

目的:评价输尿管结石中西医结合防治临床路径的实施效果.方法:选择2017年7月—2018年12月在江苏省第二中医院泌尿外科住院且符合纳入标准并接受中西医结合输尿管结石防治临床路径的患者,其中治疗组35例,根据输尿管结石防治临床路径治疗,对照组35例接受常规治疗.两组患者中医临床疗效、住院时间、住院费用、手术时间、术后清石率、手术前后炎性指标改变、患者的满意度、疾病知晓度、改善愈后等方面进行比较研究.结果:临床疗效:治疗组(94.3％)显著优于对照组(80％),差异有统计学意义(P<0.05);同时,治疗组在手术时间、住院天数、术后炎性指标:白细胞计数、C反应蛋白(CRP)、降钙素原(PCT)改变、术后1天清石率、术后1年结石复发率均显著优于对照组,差异有统计学意义(P<0.05);住院总费用、抗生素和药物费用上治疗组明显低于对照组,差异具有统计学意义(P<0.05);在患者满意度及对疾病掌握程度治疗组优于对照组,差异具有统计学意义(P<0.05);围手术期并发症两组无统计学差异(P>0.05).结论:输尿管结石中西医结合防治临床路径指导治疗,可以提高临床疗效,减少抗生素和西药使用,促进恢复,降低总费用,提高患者满意度和对疾病的知晓度.

Linshu Decoction combined with levofloxacin is more effective than levofloxacin alone in the treatment of lower urinary tract symptoms in patients with type ⅢA prostatitis.

目的:分析针灸联合生物反馈对压力性尿失禁患者尿流动力学的影响.探讨其在压力性尿失禁治疗中的潜在临床作用机制.方法:将65例SUI患者随机分为两组,对照组32例采用生物反馈治疗,观察组33例在此基础上给予针灸治疗,观察两组治疗前后尿流动力学参数改变情况.结果:与治疗前比较,治疗后对照组的尿流率(Qmax)、达峰时间(TQmax)、排尿时间(VT)、尿量(VV)、残余尿量(PVR)、咳嗽时腹压漏尿点压力(CPLL)、最大尿道闭合压(MUCP)、膀胱收缩指数(BCI)及Qmax时的逼尿肌压力(Pdet.Qmax)显著优于治疗前,差异均有统计学意义(P<0.05),观察组不仅上述指标有改善,同时初次尿感容量(FS)、强烈尿感容量(SS)、膀胱顺应性(BC)也显著优于治疗前,差异均有统计学意义(P<0.05).与对照组比较,治疗后观察组Qmax、TQmax、RUV、ND、SD、CLPP、Pdet-Qmax、MUCP、BC指标显著改善,差异均有统计学意义(P<0.05).结论:针灸联合生物反馈改善SUI临床疗效机制与协调膀胱逼尿肌和尿道括约肌功能和提高尿道闭合压密切相关.

目的 观察 F6.0/7.5输尿管镜下钬激光碎石术治疗的临床效果.方法 输尿管结石患者 231例分为两组,分别采用 F6.0/7.5输尿管镜(观察组,119例)和 F8.0/9.8输尿管镜(对照组,112例)钬激光碎石术治疗.比较两组疗效和相关并发症发生情况.结果 与对照组比较,观察组置镜成功率高(99.2％vs.93.8％)(P＜0.05),手术时间短[(27.31±9.9)min vs.(45.4±13.7)min](P＜0.05),住院时间短[(3.5±1.3)d vs.(5.2±1.5)d](P＜0.05).观察组一次碎石成功率稍高于对照组(95.0％vs.90.6％),但差异元统计学意义(P＞0.05).观察组术后尿路感染发生率为2.5％,输尿管狭窄发生率为 3.6％,稍低于对照组的 6.3％和 4.2％(P＞0.05).结论 采用 F6.0/7.5输尿管镜行钬激光碎石术临床疗效较 F8.0/9.8输尿管镜好.