This study aimed to assess the prevalence and clinical characteristics of obstructive sleep apnea (OSA) in pneumoconiosis patients using home sleep apnea tests (HSAT) and to identify associated risk factors. This study is a single-center, cross-sectional investigation. Data collection encompassed clinical information, lung function, and arterial blood gas analysis. Additionally, patients completed questionnaires such as the STOP-BANG, Pittsburgh Sleep Quality Index (PSQI), Generalized Anxiety Disorder 7-item (GAD-7), and Patient Health Questionnaire-9 (PHQ-9). The study enrolled 217 pneumoconiosis patients. Finding showed that 82

Background Obstructive sleep apnea (OSA) and coronavirus disease 2019 (COVID-19) share key pathophysiological features, including intermittent hypoxemia, systemic inflammation, and endothelial dysfunction, which may worsen clinical outcomes. However, whether OSA independently increases the risk of COVID-19 pneumonia remains unclear. This study aimed to assess the association between OSA and the risk of COVID-19 pneumonia in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Methodology In this single-center, cross-sectional study, 136 hospitalized patients with confirmed SARS-CoV-2 infection were evaluated. OSA was diagnosed using home sleep apnea testing (HSAT), defined by an apnea-hypopnea index (AHI)≥five events/hour. Propensity score matching (PSM) was performed at a 1:1 ratio based on age, sex, body mass index (BMI), smoking history, and hypertension. Multivariate logistic regression was used to identify independent risk factors for COVID-19 pneumonia. Results The overall prevalence of OSA among patients infected with SARS-CoV-2 was 36.76% (50/136). After PSM, 32 patients with OSA were matched to 32 controls without OSA. The prevalence of pneumonia-related abnormalities on chest computed tomography (CT), including patchy or ground-glass opacities, was significantly higher in the OSA group compared to the non-OSA group. Furthermore, patients with OSA exhibited more severe nocturnal hypoxemia, as reflected by elevated oxygen desaturation index (ODI) and increased total sleep time with oxygen saturation below 90% (TST90). Multivariate logistic regression analysis identified age ≥60 years (odds ratio (OR)=12.05, p=0.004) and the presence of OSA (OR=4.56, p=0.010) as independent risk factors of COVID-19 pneumonia. Conclusions OSA was common among patients infected with SARS-CoV-2 and was independently associated with an increased risk of developing COVID-19 pneumonia, even after adjustment for major confounders. Patients with OSA exhibited more frequent radiological evidence of pneumonia and worse sleep-related respiratory parameters.

Liver fibrosis is characterized by the excessive accumulation of extracellular matrix proteins, which can lead to cirrhosis and liver cancer. Metabolic dysfunction-associated steatosis liver diseases are common causes of liver fibrosis, sharing a similar pathogenesis with carbon tetrachloride (CCl₄) exposure. This process involves the activation of hepatic stellate cells (HSCs) into myofibroblasts. However, the detailed mechanism and effective treatment strategies require further investigation. In this study, we uncovered a negative correlation between VDR expression and YAP within HSCs. Subsequently, we demonstrated that VDR exerted a downregulatory influence on YAP transcriptional activity in HSCs. Intriguingly, activation VDR effectively inhibited the culture induced activation of primary HSCs by suppressing the transcriptional activity of early YAP. Furthermore, in vivo results manifested that hepatic-specific deletion of YAP/TAZ ameliorates CCl4-induced liver fibrosis, and nullified the antifibrotic efficacy of VDR. Importantly, a YAP inhibitor rescued the exacerbation of liver fibrosis induced by hepatic-specific VDR knockout. Moreover, the combined pharmacological of VDR agonist and YAP inhibitor demonstrated a synergistic effect in diminishing CCl4-induced liver fibrosis, primary HSCs activation and hepatic injury in vivo. These effects were underpinned by their collective ability to inhibit HSC activation through AMPK activation, consequently curbing ATP synthesis and HSCs proliferation. In conclusion, our results not only revealed the inhibition of VDR on YAP-activated liver stellate cells but also identified a synergistic effect of VDR agonist and YAP inhibitor in an AMPKα-dependent manner, providing a practical foundation for integration of multi-targeted drugs in the therapy of CCl4-induced hepatic fibrosis.

Abstract Background Sedentary behavior has been demonstrated to be a modifiable factor for several chronic diseases, while coffee consumption is believed to be beneficial for health. However, the joint associations of daily sitting time and coffee consumption with mortality remains poorly understood. This study aimed to evaluate the independent and joint associations of daily sitting time and coffee intakes with mortality from all-cause and cardiovascular disease (CVD) among US adults. Methods An analysis of a prospective cohort from the 2007–2018 National Health and Nutrition Examination Survey of US adults (n = 10,639). Data on mortality were compiled from interview and physical examination data until December 31, 2019. Daily sitting time was self-reported. Coffee beverages were from the 24-hour diet recall interview. The main outcomes of the study were all-cause and cardiovascular disease mortality. The adjusted hazard ratios [HRs] and 95% confidence intervals [CI] were imputed by Cox proportional hazards regression. Results Among 10,639 participants in the study cohort, there were 945 deaths, 284 of whom died of CVD during the follow-up period of up to 13 years. Multivariable models showed that sitting more than 8 h/d was associated with higher risks of all-cause (HR, 1.46; 95% CI, 1.17–1.81) and CVD (HR, 1.79; 95% CI, 1.21–2.66) mortality, compared with those sitting for less than 4 h/d. People with the highest quartile of coffee consumption were observed for the reduced risks of both all-cause (HR, 0.67; 95% CI, 0.54–0.84) and CVD (HR, 0.46; 95% CI, 0.30–0.69) mortality compared with non-coffee consumers. Notably, joint analyses firstly showed that non-coffee drinkers who sat six hours or more per day were 1.58 (95% CI, 1.25–1.99) times more likely to die of all causes than coffee drinkers sitting for less than six hours per day, indicating that the association of sedentary with increased mortality was only observed among adults with no coffee consumption but not among those who had coffee intake. Conclusions This study identified that sedentary behavior for more than 6 h/d accompanied with non-coffee consumption, were strongly associated with the increased risk of mortality from all-cause and CVD.

目的 探讨职业性接触苯及酮类物质对从业人员人群健康的影响.方法 于2021年对苏州市某区企业的从业人员进行职业健康体检,采用描述性统计学方法对健康资料进行分析.结果 对照组,不接触任何有毒有害物质的健康体检人员243人;苯暴露组,仅接触苯类物质且超过1年的在职人员222人;苯及酮暴露组,仅接触苯及酮类物质且超过1年的在职人员63人;未发现仅接触酮类物质的从业人员.中间细胞计数、中间细胞百分比为苯及酮暴露组＞苯暴露组＞对照组,红细胞平均血红蛋白浓度为对照组＞苯暴露组＞苯及酮暴露组,以上差异均有统计学意义(P值均＜0.05).总蛋白水平,苯及酮暴露组＞苯暴露组＞对照组;白蛋白水平,苯暴露组＞对照组＞苯及酮暴露组;以上差异均有统计学意义(P值均＜0.05).结论 职业性接触苯及酮类物质对人群的血尿指标均有一定的影响,应加强对此类人群的职业健康监护.

Abstract Workers are frequently exposed to the occupational hazards of ionizing radiation and noise. Co-exposure to these hazards is not well understood in terms of their physiological effects. The aim of this study was to investigate the physiological effects of co-exposure to ionizing radiation and noise within the occupational limit. This study extracted the physical examination parameters of workers who met the screening criteria from the occupational health surveillance database. The workers were divided into three groups: the co-exposure (COE) group, the ionizing radiation exposure (ION) group, and the non-exposure (NON) group. The age and sex of the three groups were matched with a sample size ratio of 1:3:3. The physical examination parameters of the three groups of workers were compared. The results showed that there was no significant difference in blood pressure and blood biochemical parameters among the three groups. The COE group had higher levels of free triiodothyronine than the ION group, but there was no difference with the NON group. Moreover, the COE group had lower levels of free tetraiodothyronine than the ION group and the NON group. There was no significant difference in thyroid stimulating hormone, total triiodothyronine, and total tetraiodothyronine among the three groups. Additionally, the number of white blood cells of the COE group was lower than that of ION group and NON group. This study suggests that co-exposure to low-dose ionizing radiation and noise can cause alterations in thyroid hormone and peripheral white blood cells. These alterations are different from those observed after single exposure to low-dose ionizing radiation and require further research.

Background Sodium bicarbonate (SB) infusion is commonly used to correct metabolic acidosis, but its clinical efficacy remains controversial. This study aims to investigate whether acid–base balance parameters should be a consideration for administering SB treatment. Methods Children with metabolic acidosis (pH < 7.35 and bicarbonate < 22 mmol/L) who were treated with or without 50 mg/ml SB injection were grouped and extracted from a retrospective cohort database of the Pediatric Intensive Care Unit. The interaction between acid–base balance parameters and SB treatment on mortality was analyzed through mortality curves and cross-effect models. Logistic regression was conducted to estimate the risk of death following SB treatment in the overall children as well as in subgroups, and potential confounding factors were adjusted for. After employing propensity score matching to account for confounding factors, further analysis was performed to evaluate the effectiveness of SB treatment within each chloride subgroup. Results A total of 5865 children with metabolic acidosis were enrolled, of which 2462 (42.0%) received SB treatment. In the overall population, it was found that SB treatment did not reduce hospital mortality or 28-day mortality. Interactions between acid–base balance parameters (chloride and anion gap) and SB treatment on mortality were observed. Subgroup analysis clarified that when chloride levels were below 107 mmol/L, children treated with SB had higher in-hospital mortality (29.8% vs 14.9%) and 28-day mortality (26.5% vs 13.4%), with adjusted ORs of 2.065 (95% CI, 1.435–2.97) and 1.947 (95% CI, 1.332–2.846), respectively. In contrast, when chloride levels were greater than or equal to 113 mmol/L, children treated with SB had a shorter stay in the PICU (median: 1.1 days vs 5.1 days, adjusted p = 0.004) and lower in-hospital mortality (4.3% vs 10.3%) and 28-day mortality (4.0% vs 8.4%), with adjusted ORs of 0.515 (95% CI, 0.337–0.788) and 0.614 (95% CI, 0.391–0.965), respectively. After controlling for confounding factors through matching, the impact of SB treatment on the risk of death in each chloride subgroup was consistent with the aforementioned results. However, treatment with SB did not significantly increase the risk of death in newborns or children with moderate to severe metabolic acidosis when chloride levels were below 107 mmol/L ( p > 0.05). Conclusions The use of sodium bicarbonate for treating metabolic acidosis has been found to increase mortality in children with low chloride levels but decrease mortality in those with high chloride levels in this study. Further prospective multi-center clinical studies and basic research are needed to validate these findings.

Background The Omicron variant of the coronavirus disease 2019 (COVID-19) virus has spread rapidly worldwide, even in areas with high vaccination rates. Consequently, it has further exacerbated the current global pandemic. In this study, we aimed to characterize the clinical severity of patients with the COVID-19 variant Omicron and analyze vaccine effectiveness in predicting clinical severity. Methodology A total of 142 patients who contracted the COVID-19 virus in the Omicron era were retrospectively studied, and differences in their clinical severity were analyzed. They were stratified as follows: unvaccinated vs. vaccinated, unvaccinated vs. one to two vaccine doses vs. three vaccine doses, and cycle threshold (CT) values ≤ 28 vs. CT > 28. Results Of the 142 patients, 27 were asymptomatic, 83 had mild disease, and 32 had moderate disease. The median age was 32 years for asymptomatic patients vs. 31 years for those with mild disease vs. 59 years for those with moderate disease (P＜0.05), and the direct medical hospitalization costs were ¥4901 for asymptomatic patients vs. ¥5259 for those with mild disease vs. ¥8378 for those with moderate disease (P＜0.05). Of the 142 patients, 112 (78.8%) were vaccinated, 11 (7.7%) had one vaccine dose, 63 (44.4%) had two vaccine doses, and 38 (26.7%) received three vaccine doses. The median direct medical cost in the vaccinated group was significantly lower than that in the unvaccinated group (¥5470.5 vs. ¥7535.5, P＜0.05). For ORF1ab and N genes, hospital stay length and direct medical cost significantly decreased in the group with CT values > 28 compared with those in the group with CT values ≤ 28 (P＜0.05). Multiple regression analysis showed that being ≥ 60 years old could be a predictor of moderate disease severity in patients, and three vaccine doses could be effective against moderate COVID-19. Conclusion Mild infection is the main clinical manifestation of the Omicron variant. Vaccination can significantly decrease direct Omicron-associated medical costs. Although vaccination cannot provide protection against severe disease caused by this variant, three vaccine doses are highly effective in preventing moderate COVID-19.

报告1例因MRI增强扫描静脉注射钆对比剂(gadolinium-based contrast agent,GBCA)后出现尿钆升高的个案.该病例静注GBCA约6 h后出现手、面部发麻,逐渐表现为全身不适,临床症状以头痛为主,后出现内脏器官灼痛、颈部皮肤紧缩感等.患者在接触GBCA 4个月后查24 h尿钆为0.097 μg/g(肌酐校正),高于美国标准[正常值范围≤0.019 μg/g(肌酐校正)]上限值5倍.予以依地酸钠钙1 g/d静脉滴注驱钆治疗,驱3 d停4 d为一疗程,共驱钆三个疗程,患者临床症状有所缓解.同时结合文献复习,对钆毒性相关疾病进行了系统介绍,提示应重视对钆毒性相关疾病的认识,做到早期诊断、早期治疗.

It is widely known that many workers are exposed to more than one occupational hazard, but little is known about the prevalence of multiple exposures to occupational hazards in the real world. In most occupational hazard risk assessments and toxicological studies, only one single occupational hazard is targeted. Recent commentaries have underlined the massive challenges associated with the identification of combinations of occupational hazards.1, 2 Identification of exposure combinations is important for public health and epidemiology since it is hypothesized that exposures induce changes in phenotype, not as a single agent, but as a collection of agents acting in concert.3, 4 Compared to the hazard risk assessment of single hazards, coexposure risk assessment presents a greater challenge due to the common existence of many types and numbers of hazards. One way to deal with this challenge is to identify combinations that are prevalent, which, in turn, might help prioritize research and interventions.5 Therefore, this study describes the prevalence of coexposure to chemical and physical hazards in China-based industrial enterprises using the database of occupational health surveillance. According to China's mandatory regulations, enterprises must arrange an occupational examination for workers who are exposed to occupational hazards. Industrial workers who were exposed to occupational hazards and underwent occupational physical examinations in our institute were included. We defined occupational exposure as the process of workers' contact with occupational hazards through the respiratory tract, skin, and other organs during occupational activities. Multiple exposure was defined as when a worker is exposed to two or more occupational hazards in the same enterprise. Enterprises in China must employ a third-party organization to identify and detect the occupational hazards that workers have been exposed to. Based on the categories of occupational hazards workers are exposed to described in the report of the third-party organization, the physical examination institution conducted examinations for workers according to technical specifications for occupational health surveillance (GBZ 188-2014). We obtained data on occupational hazards, age, and gender from the occupational physical examination system. Enterprises are classified according to the industrial classification system used for China's national economic activities (GB/T 4754-2017). All procedures performed in the study coincided with the 1964 Declaration of Helsinki as well as its later amendments or comparable ethical standards. Categorical variable was described by frequency (percentage), and continuous variable was described by mean ± standard deviation or median (interquartile range, IQR). All statistical analyses were performed using the R version 4.1.1 software (R Core Team, 2021), with the pheatmap package for the heat-map procedure and the igraph package for the network procedure. The study focused on 10,363 workers (71.4% males) exposed to occupational hazards who came from 371 industrial enterprises. The average age of workers was 29.0 ± 6.5 years. The distribution of occupational hazards in various industries is shown in Figure 1. In most industries, benzene and its homologs (including toluene, xylene, and ethyl benzene, etc., BTXE) were the primary hazards for occupational exposure, accounting for 43.2% of the total. Exposure to noise, ionizing radiation, nonmetallic dust, alcohols, ketones, ester, acid, alkane, and alkaline also play an important role in several industries, accounting for about 10%−20% of occupational hazards. The median number of occupational hazards workers experienced was 3.0 (IQR: 3.0–5.0). The proportion of workers exposed to two or more hazards reached 75.2%, those exposed to five or more hazards reached 33.8%, and exposure to 10 hazards or more reached 7.2%. The cross and net analysis results of coexposure are shown in Figure 2. BTXE hazards were the most common partner in coexposures. Cross-combination analysis showed that the proportion of workers exposed to BTXE combined with noise reached 12.8%, with nonmetallic dust reached 10.6%, and with alcohols or ketones reached even 20%. BTXE combined with noise, nonmetallic dust, alcohols, ketones, esters, and acids formed a coexposure cluster. This clustering trend can also be seen in the tree in Figure 1. The proportion of workers exposed to any two or more of the seven hazards reached 37.4%, the proportion of any three or more reached 26.8%, and the proportion of any four or more reached 15.3%. The combined exposure frequency of alkane, alkaline, furan, and other hazards was also striking. This study has described the multiple, coexposures of workers to occupational hazards in the real world in China. Utilizing the monitoring database to analyze multiple exposures to occupational hazards has also been reported in other studies.2, 6 The group of workers analyzed in the study came from the largest industrial enterprises zone in China, where there are many types of industrial enterprises. To some extent, the results of this study can represent the current situation of workers' multiple occupational exposures. The prevalence of multiple exposures poses a more difficult challenge for industrial enterprises as they seek to provide effective protective measures for workers. For example, if a worker is exposed to splashing harmful chemicals and works in a high-temperature environment, wearing protective equipment to prevent splashing contact will inevitably make it more difficult for a worker to adapt to the high-temperature working environment. Industrial enterprises need to make more efforts in the design and improvement of protective equipment, shift work and rest, mechanized operation, and so on. Among the occupational hazards workers are exposed to in various industries, BTXE were the primary hazards, and they also cross-linked with noise, nonmetallic dust, alcohols, ketones, esters, and acids to form a significant coexposure cluster. The detrimental health effects on workers exposed to BTXE in combination with other occupational hazards has been observed by some researchers. For example, it was found that noise combined with benzene−toluene−xylene exposures in painting workshops of automobile manufacturing enterprises had a positive influence on the systolic blood pressure of workers.7 Male occupational exposures to multiple solvents (benzene, methylene chloride, toluene, trichloroethylene, perchloroethylene, and 1,1,1-trichloroethane) increased the risk of amyotrophic lateral sclerosis.8 Nevertheless, the current understanding of the health effects of multiple exposures is far from sufficient. When understanding this study, the following limitations should be noted. First, the health monitoring database used in this study recorded the categories of occupational hazards workers are exposed to and the results of occupational health examination parameters, but there were no data on the duration and dose of workers exposed to various occupational hazards. Hence, when analyzing multiple exposures, this study could not identify the weight of exposure time and dose of each hazard. Second, the sample selection of this study is nonrandom sampling, which may have potential bias. In conclusion, multiple exposures of industrial workers to occupational hazards are prevalent, and BTXE, noise, nonmetallic dust, alcohols, ketones, esters, and acids often cross-link to form a significant coexposure cluster in industrial workers. Conceptualization: Yan-mei Cao and Wen-yi Liu. Data collection: Wei-min Gao and Liang-bin Xie. Analysis and interpretation of data: Hua-qing Liu. Writing—original draft preparation: Hua-qing Liu, Wen-yi Liu, and Yan-mei Cao. Writing—review and editing: Hua-qing Liu and Yan-mei Cao. All authors have read and approved the final version of the manuscript. We would like to thank Wordvice (https://wordvice.cn/) for English language editing. This study was supported by the Health Commission of Suzhou (SZYJTD201904). The authors declare no conflicts of interest. The work was performed at the Fifth People's Hospital of Suzhou and was approved by the Medical Ethics Committee of the Fifth People's Hospital of Suzhou on June 11, 2021 (code: 2021016). The corresponding author confirms that the manuscript is an honest, accurate, and transparent account of the study being reported. The data supporting the findings of this study are available from the corresponding author upon reasonable request.

Abstract Background: Metabolic acidosis is a common acid-base imbalance in critically ill patients. Whether sodium bicarbonate (SB) can improve clinical outcomes in the treatment of metabolic acidosis is still controversial. The aim of this study was to determine the factors influencing the clinical efficacy of SB in the treatment of metabolic acidosis and the potential benefit to patients. Methods: Patients with metabolic acidosis who were treated with or without SB were identified and grouped from a retrospective cohort (Pediatric Intensive Care Unit [PICU] database), from which the clinical data were extracted. The in-hospital mortality curves of the acid-base balance parameters of patients in the two groups were drawn and fitted using the locally-weighted scatter plot smoothing (LOWESS) method. The prevalence ratios (PRs) of in-hospital mortality were estimated by log-binomial regression based on the maximum likelihood method, and the potential confounders, such as age and disease category, were adjusted. Results: A total of 6,167 children with metabolic acidosis were enrolled, of whom 2,626 (42.58%) were treated with SB. The overall analysis showed that there was no significant difference in the in-hospital mortality rates (9.71% vs. 10.56%, p = 0.275) between children in the SB treatment and non-treatment groups, adjusted PR = 0.929 (95% CI, 0.802-1.072). There was no significant difference in the in-hospital mortality rates as a function of pH and HCO3- between the two groups. The in-hospital mortality rate as a function of chloride was significantly different; specifically, the curve of the untreated group was U-shaped and the curve of the treated group was L-shaped. The curves of the two groups crossed at 110 mmol/L of chloride after LOWESS fitting. There was no statistically significant difference in the risk of death between the SB treatment and non-treatment groups at a chloride < 107 mmol/L and a chloride >113 mmol/L. In the chloride < 107 mmol/L subgroup, SB treatment had a 41.7% increased risk of in-hospital death (adjusted PR=1.417, 95% CI, 1.069−1.481) and a 35.9% increased risk of 28-day death (adjusted PR=1.359, 95% CI, 1.315−1.474). In the chloride≥113 mmol/L subgroup, SB treatment had a 61.1% reduced risk of in-hospital death (adjusted PR=0.389, 95% CI, 0.268−0.553) and a 56.4% reduced risk of 28-day death (adjusted PR=0.436, 95% CI, 0.295−0.631). The median length of stay in the PICU of children in the SB group was also shorter than children in the non-treatment group when the chloride concentration was ≥110 mmol/L. Conclusions: The clinical outcomes of SB in the treatment of metabolic acidosis are associated with chloride. When the chloride concentration was high (> 110 mmol/L), children benefited from SB treatment and when the chloride concentration was low (< 107 mmol/L), the risk of death increased.

目的 了解尘肺病患者的维生素D水平,并分析维生素D与炎症因子、淋巴细胞亚群各指标之间的相关性.方法 选取60名老年男性健康体检人员为对照组,182名尘肺病患者为研究组,比较两组的维生素D水平;同时分析研究组维生素D水平、尘肺病期别与炎症因子、淋巴细胞亚群的相关性.结果 182名尘肺病患者维生素D缺乏人员的占比高于对照组(P＜ 0.05).研究组平均25(OH)D水平为(21.55 ± 9.51)ng/mL,显著低于对照组的(27.16±8.12)ng/mL(P＜ 0.01).182名尘肺病患者的炎症因子,包括白介素2受体(IL-2R)、白介素-6(IL-6)、白介素-8(IL-8)、降钙素原(PCT)、C反应蛋白(CRP)随着尘肺病期别的升高而升高(P＜0.05);IL-6在维生素D充足组最低(P＜ 0.05),IL-8、PCT及CRP随着25(OH)D水平的升高逐渐降低(P ＜ 0.05);壹期尘肺病患者CD4/CD8值高于贰、叁期患者(P＜ 0.05),CD4+T细胞、L/CD45随着尘肺分期的升高而降低(P ＜ 0.05);随着25(OH)D水平的升高,CD4+T细胞占比、L/CD45逐渐升高,而CD8+T细胞逐渐下降;25(OH)D与CRP水平呈弱的负相关(r =-0.191,P＜0.05),25(OH)D与IL-10、CD4/CD8值、L/CD45呈弱的正相关(r = 0.299、0.176、0.257,P ＜ 0.05).结论 尘肺病患者维生素D缺乏或不足率较高,尘肺病患者体内的维生素D可能通过调节炎症因子及细胞因子参与炎症反应及免疫功能.

对1例职业性急性苯胺中毒患者的临床表现、实验室检查、治疗方案及病情转归等资料进行综合分析.探讨职业性急性苯胺中毒患者的解毒及发生溶血性贫血后的临床救治措施.

对苏州市1971—1974年参加某空军部队从事采掘作业并诊断为尘肺的85例患者进行25-(OH)D及相关指标的检测.85例尘肺患者25-(OH)D平均水平为(28.60±6.05)ng/ml,58.8％的患者25-(OH)D不足(＜30 ng/ml).Spearman相关分析显示,血清25-(OH)D水平与球蛋白、天冬氨酸氨基转移酶、免疫球蛋白A、降钙素原呈正相关(r=0.238、0.228、0.254、0.237,P＜0.05),而血清25-(OH)D水平与部分凝血活酶时间呈负相关(r=-0.269,P＜0.05).提示国防施工尘肺患者存在较为严重的维生素D缺乏,维生素D与多种指标具有相关性.