Purpose: to analyze clinical polymorphism of endocrine ophthalmopathy in patients with Graves’ disease.Methods: Clinical and radiological data of 18 cases with clinical manifestations of lacrimal gland increase were analyzed and compared with data retrieved from 50 patients without increasing of lacrimal gland.Results: the characteristics of clinical manifestations of endocrine ophthalmopathy with lacrimal gland increase were presented. this form differs, as the organ of the target, along with orbital fat and/or eye muscles becomes the glandula lacrimalis. A correlation between fact involving, on the one hand, and the intensity and severity of the autoimmune process in orbit, on the other hand were identified.Conclusion: Involvement of this secretion organ in the autoimmune process makes the clinical course of endocrine ophthalmopa-thy more complicated, and leads to eye dry syndrome creation.

A total of 139 patients (278 eyes) presenting with Graves' disease (GD) and endocrine ophthalmopathy (EOP) were examined. The age of 35 men and 104 women ranged from 17 to 71 years. All of them were tested for the functional activity of the thyroid gland and underwent standard ophthalmologic examination; anti-TSH receptor antibodies were measured. Both the activity and severity of EOP were verified as recommended by the European Group on Graves' Orbitopathy (EUGOGO) It was shown that the frequency of detection of anti-TSH receptor antibodies and their titers in patients with GD and EOP depended on the activity of the intraorbital process and the severity of EOP manifestations. The functional state of the thyroid gland also influenced the level of anti-TSH receptor antibodies level during the active phase unlike that in the inactive phase. The in-depth analysis of the relationship between the level of anti-TSH receptor antibodies and clinical characteristics of either EOP (activity, severity, manifestation of selected clinical symptoms) or GD (thyrotoxicosis, euthyroidism, hypothyroidism) demonstrated the possibility to use these characteristics as the factors predicting the severity and outcome of EOP. Also, they may be helpful for the choice of a therapeutic strategy for the treatment of such patients.

Purpose. To evaluate the relationship of clinical and radiologic findings in improving of diagnostics and amendment of the outcome.Material and methods. 52 patients (104 orbial cavities) in the age of 18–61 years were examined. Patients with the clinical symptoms of Grave’s orbitopathy were examined using ophthalmological evaluation and MSCT-visualization of orbial cavities.Results. The most significant MSCT-parameters for the determination of severity are: prolapse of orbital fat (р = 0.0009), protrusion of eye bulb (р = 0.001), apical inspissations (р = 0.019), density of RBCmin (р = 0.004), size of external terminal membrane (р = 0.001), size of LRM (р = 0.002), size of MRM (р = 0.006), length of optic nerve (р = 0.0001), diameter of optic nerve in 1 cm from the macula (р = 0.01), width of lacrimal gland (р = 0.0002).Conclusions. There is significant relationship between clinical and radiologic (MSCT) features. It lets develop the protocolof examination for diagnostics and treatment of Grave’s orbitopathy.

Purpose. To evaluate the relationship of clinical and radiologic findings in improving of diagnostics and amendment of the outcome.Material and methods. 52 patients (104 orbial cavities) in the age of 18–61 years were examined. Patients with the clinical symptoms of Grave’s orbitopathy were examined using ophthalmological evaluation and MSCT-visualization of orbial cavities.Results. The most significant MSCT-parameters for the determination of severity are: prolapse of orbital fat (р = 0.0009), protrusion of eye bulb (р = 0.001), apical inspissations (р = 0.019), density of RBCmin (р = 0.004), size of external terminal membrane (р = 0.001), size of LRM (р = 0.002), size of MRM (р = 0.006), length of optic nerve (р = 0.0001), diameter of optic nerve in 1 cm from the macula (р = 0.01), width of lacrimal gland (р = 0.0002).Conclusions. There is significant relationship between clinical and radiologic (MSCT) features. It lets develop the protocolof examination for diagnostics and treatment of Grave’s orbitopathy.

Diabetes mellitus is a group of metabolic metabolic) diseases characterized by hyperglycemia that results from defects in insulin secretion, insulin action, or both of these factors (WHO, 1999). In the last etiological classification (WHO, 1999), 4 clinical types of diabetes mellitus are distinguished: type 1, type 2, other types (infections, genetic disorders, etc.) and gestational diabetes. Type 1 diabetes mellitus includes diseases caused by destruction (pancreatic β-cells, absolute insulin deficiency and a tendency to ketoacidosis. The vast majority of such cases have an autoimmune nature of the lesion, but there are groups of patients who do not show autoimmune markers Taking this into account, according to this classification, type 1 diabetes includes 2 types: autoimmune and idiopathic. Idiopathic diabetes is also called type 1B diabetes, atypical type 1 diabetes , ketosis-prone diabetes, tropical diabetes.

Синдром Вольфрама ? аутосомно-рецессивное заболевание, связанное с гомозиготной или несколькими гетерозиготными мутациями в гене синдрома Вольфрама (WFS1), расположенном на коротком плече 4-й хромосомы в положении 16. Распространенность синдрома Вольфрама составляет 1 на 770 ООО населения в Великобритании и 1 на 100 000 населения в США . По некоторым данным, риск заболеваемости синдромом Вольфрама возрастает у детей, рожденных от родителей, состоящих в близкородственных связях. Синдром Вольфрама включён в этиологическую классификацию сахарного диабета в группу других генетических синдромов, сочетающихся иногда с сахарным диабетом.