Introduction. Mechanisms of change in vascular reactivity and synthetic endothelial function remain controversial in thyroid pathology. Controlled hemostasis in areas of vascular injury is one of the important functions of the endothelium. Lack of coordination between synthetic and vasomotor endothelial function may be a possible cause of increased tissue bleeding in the surgical treatment of toxic goiter. Methods. Endothelial function and guanylate cyclase activity of smooth muscle cells of the brachial artery (GCAM) were studied in a prospective observational study. 49 women aged 44 (33; 50) years were examined. Vasomotor function of the brachial artery in response to short-term ischemia (EDVD) and oral administration of nitroglycerin (ENVD), flow-induced production of endothelin-1, prostacyclin and nitric oxide were measured. The parameters were evaluated in hyperthyroidism, drug-treated hyperthyroidism and on the 4–5 day after thyroidectomy in postoperative hypothyroidism. Results. We have established the consistency of flow-induced production of nitric oxide and endothelin-1 (r = 0.78; p = 0.01) in toxic goiter. Paradoxical vasoconstriction in response to sublingual glyceryl trinitrate administration or short-term ischemia was associated with excessive level of endothelin-1 (> 0.36 fmol/ml; p = 0,05) and TSH suppression < 0.03 mIU/L (p = 0.003). The magnitude of the EDVD varied depending on the ENVD and flow-induced production of prostacyclin (R = 0.87; RI = 0.75; p = 0.00001). Deleting of the thyroid gland led to a decrease of EDVD and increase of GCAM. The relationship between the magnitude of variability of these parameters had a linear character (r = 0.66; p = 0.02). Findings. TSH suppression below 0.03 mIU/L in toxic goiter is accompanied with excessive synthetic endothelial function, which is implemented in a paradoxical vasoconstriction. Increased ability of the endothelium to synthesize prostacyclin may be a possible cause of increased tissue bleeding while removing toxic goiter.

The aim of the work was to study the peculiarities of the influence of bloodfactors on the development of spherocytosis in patients with coronary disease and arterial hypertension. The study involved 30 patients with coronary disease and 24 patients arterial hypertension with the study of their clinical status and biochemical parameters of blood, hemostasis, blood cell analysis. It was found that the increase in the pool spherocytic cells in patients with arterial hypertension were associated with increased nitric oxide production, while in patients with coronary disease spherocytosis was due to an increase in the concentration of reactive oxygen metabolites.

This review presents the observation of the role of endothelial dysfunction in development of atherosclerosis, coronary disease and. hypertension. Among other causes of endothelial dysfunction the most significant are hemodynamic factors (wall transverse strain, transmural pressure), dyslipoproteinemia, hyperhomocysteinemia, hyperglycemia, free radical damage of endothelium. It is supposed that in development and. progressing of coronary disease more significant role may belong to endothelial dysfunction rather than to morphological vascular changes, predetermined by atherosclerosis. However, there is still no clear view of development of endothelial dysfunction and. mechanisms of development and. progressing of both isolated forms of coronary disease and arterial hypertension and their combination.

General principles of erythrocyte's cytoskeleton structure and structural and functional features of its membrane are observed in the article. Data about the role of different components of erythrocyte membrane in their interaction with extracellular matrix are given. Main typical breaks of structure and function of blood red cells at pathologies of different genesis are shown.

Patients with FC II-IV CHD and angina of effort were divided into 3 groups (compensated, subcompensated, and decompensated types) based on vascular reaction to local ischemic load Serum lipid spectrum, parameters of hemostasis and blood flow were evaluated before and after the load. It was shown that each type of vascular reaction had specific predictors. Vasodilation in "compensated" patients was largely due to hydrodynamic changes in the vascular bed. The "subcompensated" type was characterized by reduced sensitivity to this changes "decompensated" type of reactivity was related to metabolic rather than hydrodynamic disorders accounting for paradoxic vasoconstriction in response to ischemic load.

Hemostatic parameters and the diameter of the brachial artery were studied in patients with functional classes II and III angina on exertion before and after an ischemic test. A multivariate statistical analysis was used to determine the significant parameters that distinguish vascular endothelial function in these patients. At the same time it was established that endothelial dysfunction in patients with varying angina pectoris is determined by different predictors of thrombocytic-vascular hemostasis.

Th e rates of blood fl ow and functional state of endothelium vascular wall were examined prior to and following the ischemic test in patients with exertional angina of the II-III functional class and in the control group. Multiparameter statistical analysis allowed determining signifi cant parameters which distinguished the given groups of patients. It was stated that endothelium dysfunction in patients with angina of diff erent severity was determined with diff erent predictors. In addition, dysfunctional changes caused by the disruption of endothelium of vascular wall were revealed in patients with angina of III functional class.

After conducted investigations it was established, that degrees of manifestation of feedback on ischemic test in practically healthy people and patients with CHD with different degree of stenocardia differ significantly. It testifies to different functional state of endothelium. Obtained, data revealed, the most informative parameters which were characteristics of feedback on ischemic test in s

The aim of the present study was the examination of imozimaza fibrinolytic properties. Also we estimated the effect of intraabdominal debridement of wound by imozimaza according to the parameters of hemostasis system in patients with purulent peritonitis.

We studied effects of neonatal hepatocytes transplantation (NHT) on lipid metabolism and hemostasis in experimental hypercholesterolemia. A positive NHT influence on lipid metabolism, lipid peroxidation and hemostasis was established. The experimental data evidence for preferential influence of intrahepatic NHT on lipid metabolism and hemostasis compared to intravenous NHT.

The work is devoted to the study of protein-peptide structure of organotypic fetal cellular suspension of human (18-20 weeks of gestation): liver, lung, heart and the similar cellular material of rabbits in 1-2 days of neonatal period. In peptide extracts the groups of angiotensins, bradykinin, enkephalins, oxytocin, somatostatin, bombesin, endothelins, endorphins, P substance, carnosine, aminooacid fraction were identified. Except that, the cellular suspensions contained fibrinogen like substances, angiotensin-II and plasminogen.