The aim of the present study is to analyze the dynamics of free circulating mtDNA level in blood after occlusion of the upper one-third left descending branch of the coronary artery. We showed that the concentration of free circulating mtDNA of blood tends to decrease 24 hours after ligation; it increased and reached values close to control samples 48 and 72 hours after ligation. These data define the need in further investigation of the dynamics of this parameter during later periods of myocardial infarction modeling that will contribute to objective evaluation of its significance for acute myocardial damage diagnostics and prognosis.

The aim of the study was to analyze the dynamics of level of free circulating mtDNA in blood in the experimental small-focal myocardial ischemia induced by subcutaneous injections of adrenaline. The level of mtDNA of blood plasma tended to decrease during first hours after adrenaline injection and it increased 2.5 times in 72 hours as compared to control subjects. A negative correlation was found between the dynamics of mtDNA level and activity of cytolysis biomarkers of the myocardium. These data open the opportunity for further research that will favor to the creation of new techniques for diagnostics and prognosis of acute myocardial injuries.

The paper presents the data on the basic sources of environmental contamination with lead and entry pathways to the human organism. The mechanisms of lead toxicity influence on the human organism are considered.

In the article the results of the experimental researching of bimetallic implante electrochemical characteristics in biological fluids have been given.

The possibilities to analyze mtDNA level of peripheral blood adipocyte and mononuclear leukocytes to predict and diagnose complications after the antiretroviral therapy. The lipoatrophy development was shown to be accompanied by mitochondrial dysfunction and a decrease in adipocytes mtDNA level. There is a decrease in mtDNA concentration of mononuclear leukocytes during the treatment with nucleoside analogues (reverse transcriptase inhibitors) that reflects therapy duration but is not associated with lipoatrophy development. The topic requires further investigation most aimed at increase of the method selectivity in respect of different cell subtypes and detailed elaboration of cellular mtDNA level dynamics