This work is devoted to the study of the in vivo stages of development of lipid infiltration of foam cells and theformation of atherosclerotic plaques from them in an experiment on “Chinchilla” rabbits. Using laser confocal microscopywe performed a three-dimensional analysis of rabbit aorta preparations (135 days of atherogenic diet) stained with Nile red.Experimental evidence suggests that atherosclerotic plaques form in areas of the aorta-attached single monocyte/macrophagethat begins to consume lipids, turning into foam cells. The topography of the distribution of these cells on the inner surface ofthe aorta determines the shape of the developing atherosclerotic plaque. Further plaque formation occurs due to an increasein lipid accumulations of already existing foam cells, the addition of new ones, the formation of lateral contacts between themand, further, multilayer structures. In general, the data obtained will serve as the basis for the creation of new methods ofdiagnosis, prevention and treatment of atherosclerosis.

The article presents experimental results of electrochemical characteristics of bimetallic implants in experiment.

Disturbance in structure and function of liver cells mitochondria under experimental dislipoproteidaemia have been studied (on 135 day). We observed a disbalance in lipoprotein fractions and an increase in alaninaminotransferase activity in blood. Lipid infiltration in liver was shown to occur under experimental dislipoproteidaemia. These are accompanied by mitochondrial cristae fragmentation, mitochondria undergo swelling, destruction and vacuolization. We observed the following disturbances in nanostructure of liver cells mitochondria under experimental dislipoproteidaemia: an increase in rough and a decrease in membrane domains square. On the whole, the observed alterations in mitochondrial membranes nanostructure serve as a cause for ultrastructural disturbances in mitochondria to occur and may lead to mitochondrial dysfunction. The further investigation of the mechanisms responsible for these disturbances in mitochondrial structure and functions will contribute to the development of new techniques to treat atherosclerosis.