Purpose: Doppler flow parameters of fetal umbilical artery (UA) and middle cerebral artery (MCA) have been widely used for fetal growth restriction (FGR), but their diagnostic efficacy remains contentious. The purpose of this study is to clarify the superiority of cerebroplacental ratio (CPR) and umbilicocerebral ratio (UCR) in terms of their correlation and predictive accuracy in diagnosing FGR. Methods: Doppler flow parameters of the UA and MCA were tested for FGR patients and normal pregnant women during the third trimester. Collection of delivery gestational weeks and neonatal birth weight were conducted. Logistic regression and area under the curve (AUC) analysis were used to elucidate the association and diagnostic accuracy of CPR and UCR for diagnosing FGR. Results: The CPR-EDV and CPR-MFV in FGR patients were higher, while the CPR-S/D, CPR-PI, and CPR-RI were lower (P<0.05). The UCR-EDV in the FGR group was lower than that in the NC group, while the UCR-S/D and UCR-PI were higher than those in the NC group (P<0.05). Only the CPR-PI (OR:0.166, 95% CI 0.049 ~ 0.563, P = 0.004) was independently associated with FGR. A positive correlation between CPR-PI and delivery gestational weeks was found, as well as neonatal birth weight. The AUC of CPR-PI for detecting FGR was 0.719 (95% CI 0.594 ~ 0.844; P=0.003), with a critical value of 1.57. Conclusion: Compared with UCR and simple UA or MCA blood flow parameters, CPR-PI may be the most optimized ultrasound parameter for diagnosing and assessing FGR.

Objective . To analyze the distribution of human papilloma virus (HPV) infection in women with cervical lesions of different grades and analyze the relationship of high-risk HPV and cervical lesions in order to facilitate targeted prevention. Methods . The infection status of HPV subtype was statistically analyzed in patients who underwent colposcopy examination from April 2017 to June 2019. Results . The infection rate of HPV was 81.4% in chronic cervicitis, 82.9% in 1ow-grade squamous intraepithelial lesion (LSIL), 63.7% in HSIL (high-grade squamous intraepithelial lesion), and 50% in cervical squamous cell carcinoma (CSCC). Among the 16 high-risk HPV types, the top six HPV types with the comprehensive infection rates were HPV16 > HPV52 > HPV58 > HPV18 > HPV51 > HPV53 in turn, and the infection rates were 23.3%, 14.8%, 13.3%, 9.8%, 9.2%, and 8.8%, respectively. The infection rates of HPV16 in chronic cervicitis group, LSIL group, and HSIL group were significantly different. There was no significant difference in the injection rates of HPV52, HPV58, and HPV18 among the three groups. HPV infection rates were highest in the 31–40 years old group, followed by the 41–50 years old group. Conclusion . The distribution of different types of HPV varies in different tissue types, which can be used to develop relevant vaccines to achieve better prevention and treatment of cervical cancer.

目的 基于Survivin信号通路探究miR-373对宫颈癌HeLa细胞增殖、侵袭和粘附能力的影响.方法 将HeLa细胞随机分为3组,转染miR-373 inhibitor质粒为miR-373组,转染miR-NC空质粒为miR-NC组,未经任何质粒转染为空白对照组.实时荧光定量PCR(qPCR)检测细胞中miR-373、Survivin表达,MTT法检测细胞增殖能力,平板克隆实验检测细胞克隆形成能力,Transwell法检测细胞侵袭能力;基质胶粘附实验检测细胞粘附能力;蛋白质印迹检测细胞中Suivivin、caspase-3、caspase-9蛋白表达.结果 和空白对照组比较,miR373组细胞中miR-373和Survivin表达均显著降低(P<0.05);miR-373组24、48、72h时细胞增殖能力,侵袭能力及粘附能力均显著降低(P<0.05);miR-373组细胞Survivin蛋白表达显著降低,caspase-3和caspase-9蛋白表达显著升高(P<0.05).结论 下调miR-373表达可抑制宫颈癌HeLa细胞的增殖、侵袭和粘附能力,其机制可能与Survivin通路有关.

Objective: To observe the clinical efficacy of lentinan combined with cisplatin and paclitaxel in the treatment of ovarian cancer with ascites. Materials and Methods: Two hundred and twelve cases of patients with epithelial ovarian cancer (EOC) and ascites were retrospectively analyzed. Patients were divided into TP (taxinol + platinol) group and TP + lentinan group according to the chemotherapy regimen. Results: The effective rate (CR + PR) in TP group (98 cases) was 31.6% and disease control rate (CR + PR + SD) was 80.6%. The effective rate in TP + lentinan group (114 cases) was 50.9% and the disease control rate was 88.6%, with statistical difference compared with TP group. The control of ascites in TP + lentinan group was better than TP group. The common adverse reactions of chemotherapy in TP + lentinan group was relative mild with reduced incidence. Conclusion: Lentinan combined with chemotherapy could enhance the efficacy of chemotherapy and control of the ascites.

Objective To investigate the clinical value of hysteroscopy in helping identify the etiology of intrauterine fluid collection in postmenopausal women.Methods One hundred and thirtyfour postmenopausal women with intrauterine fluid collection,detected via transvaginal sonography,were admitted in the department of gynecology and obstetrics at Beijing ChaoYang Hospital from May 2014 to October 2016.All clinical data were retrospectively analyzed.All patients underwent hysteroscopy and biopsy of the endometrium.The results of hysteroscopy were analyzed against biopsy results.Results Hysteroscopy revealed that 116 of the 134 cases had uterine fluid(86.6％).Based on hysteroscopy results,44 (37.9 ％) had endometritis,10 (8.6 ％) had atrophic endometritis,5 (4.3 ％) had endometrial carcinoma,and 7(6.0 ％)had endometrial polyps,but the case numbers and rates for these conditions from microscopic examination were39 (33.6％),15 (12.9％),6 (5.2％),and 7 (6.0 ％),respectively.When microscopic examination was used as the gold standard,the sensitivities and specificities of hysteroscopy in the diagnosis of endometritis,atrophic endometritis,endometrial cancer and endometrial polyps were 82.0 ％ and 85.7 ％,66.7 ％ and 97.1％,80.0 ％ and 98.2 ％,and 100.0％ and 97.3％,respectively.The diagnostic coincidence rates were 84.6％,93.2％,94.4％ and 97.4％,respectively.Conclusions Postmenopausal women with intrauterine fluid collection shown on transvaginal sonography should receive hysteroscopy for early detection of endometrial lesions.

Objective To explore the feasibility of trans-obturator tension-free vaginal tape for female stress urinary incontinence(SUI) performed during gynecologic surgery.Methods Twelve females with benign gynecologic disease and stress urinary incontinence were treated with trans-obturator tension free vaginal tape during gynecologic surgery.Nine patients had uterine and vaginal anterior wall prolapse,2 with uterine myoma and 1 with endometriosis.The operation time,blood loss and complications were recorded. Results The patient′s average age was 58.5 years.All the TVT-O operations were finished between 15-25 minutes(mean 19.8 minutes) and with the estimated blood loss of 20-40 ml(mean 22 ml).None of them had bladder injury,hematoma or nerve damage.During follow up from 2 to 12 months(mean 8.2 month),12 patients were cured successfully without urinary incontinence recurring.The cure rate was 100%.Conclusion Trans-obturator tension-free vaginal tape during gynecologic surgery is a practical procedure with little more operating time,less risk of infection,minimal invasion and better outcomes for patients with gynecologic disease and stress urinary incontinence.Colposcopy is not necessary because less risk of injury to the bladder.