Efficacy of two antibiotics in patients with acute bacterial maxillar sinusitis was studied. Patients (age 18-65 years) received amoxicillin/clavulanic acid or levofloxacin per os. Therapy with levofloxacin led to eradication of pathogen in 21 cases (35%) at the third day and in 28 cases (47%) at the fourth day that corresponded to clinical picture. The full clinical recovery taken up 5 days in average. Levofloxacin was effective antibiotic in the treatment of patients with acute bacterial sinusitis. Clinical and microbiological efficacy of levofloxacin reached 100%.

Five-year monitoring of microbial environment of the ENT department stated its relative qualitative persistence. Circulating in hospitals microbial strains have a direct influence on the course of the infectious process in the patients. Hospital infection in the ENT department replaces the initial pathogen for a polyresistant hospital pathogen or forms a persistent microbial association.

The comparison of the efficacy of a number of antibacterial drugs in acute pyoinflammatory ENT diseases allowed the authors to recommend moxifloxacin as most effective in acute purulent ENT pathology. Moxifloxacin demonstrated its superiority in seeding (the highest sensitivity of the bacteria to this antibiotic), in the speed of development of the bactericidal action and in treatment results. The drug had no significant side effects.

A dynamic 4-year monitoring of aerobic bacterial environment in the ENT department shows its relative qualitative stability with predominance of the coccal flora, primarily staphylococcal. Gram-negative flora was represented for the most part with non-fermentating microorganisms, most of them Acinetobacter. A wide-spectrum resistance to antibacterial drugs was found. This resistance has a trend to extend.