The article contains a description of generalized sarcoidosis diagnosed morphologically after cholecystectomy for phlegmonous cholecystitis.

The review analyzes 21 publications on sarcoidosis pathogenesis, clinical course, treatment characteristics (sarcoidosis in the COVID-19 era), and prognostic aspects during the COVID-19 pandemic.

In the article the analysis of dynamics of indicators of oncological morbidity of the Ryazan region (RO) for the period from 2004 to 2014 was held. Presents the results of the comparative analysis of these indicators with the average indicators across Russia in 2014. Found that, despite progress made to reduce mortality from malignant neoplasms (EIT), the tendency to steady growth of indicators of morbidity. When comparing statistical indicators in a number of regions of Russia has its own peculiarities, caused by a number of demographic and social reasons. Also over the last 10 years there have been changes in the structure of oncological pathologies, which should lead to the adjustment of the priority directions in the diagnosis and treatment of cancer.

The article is dedicated to the study of occurrence, characteristics and drug resistance trends among patients with TB relapses in Ryazan region. We have shown a tendency to MDR and simultaneous drug resistance share increase in the ratio to the three anti-TBdrugs of the 1st line, as well as a tendency to monoresistance share decrease at the relapse time as compared with the moment of the initial disease detection. It has been found out that the period before drug-resistant TB relapse emerging is with certainty shorter than that before the relapse uprise of the TB generated by the drug-sensitive mycobacteria tuberculosis.

The given article is dedicated to the study of occurrence, characteristics and drug resistance trends among patients with TB relapses in Ryazan region. We have shown a tendency to MDR and simultaneous drug resistance share increase in the ratio to the three antituberculous preparations of the 1st line, as well as a tendency to monoresistance share decrease at the relapse time as compared with the moment of the initial disease detection. It has been found out that the period before drug-resistant TB relapse emerging is with certainty shorter than that before the relapse uprise of the TB generated by the drug-sensitive mycobacteria tuberculosis.

The article is devoted to drug-resistant tuberculosis in the Ryazan region. There is a tendency to the increase of the amount of tubercular patients among women of middle ages. It is stated that in the period from 1999 to 2007 mycobacteria’s structure of drug-resistance has not changed considerably. The exception was a dramatic increase of cases with simultaneous drug-resistance to the four first-line antibiotics. The direct interdependence between the character of drug-resistance and the speed and intensity of tuberculosis microorganisms growth has not been found yet.