The article contains a description of generalized sarcoidosis diagnosed morphologically after cholecystectomy for phlegmonous cholecystitis.

The review analyzes 21 publications on sarcoidosis pathogenesis, clinical course, treatment characteristics (sarcoidosis in the COVID-19 era), and prognostic aspects during the COVID-19 pandemic.

The article presents a clinical case of myocardial infarction in the early postoperative period after lung resection due to tuberculosis in a 51-year-old patient; clinical manifestations, diagnosis, management tactics and successful treatment are described. In 24 hours after the diagnosis was made, the patient underwent emergency stenting of the right coronary artery in the cardiologic dispensary.The authors state that they have no conflict of interests.

The article presents data from the literature devoted to studying the evolution of M. tuberculosis and the matter of the process which resulted in the modern diversity of tuberculous mycobacteria. Molecular methods with other auxiliary tools helped to change the view on history of M. tuberculosis complex, leading to the development of a new evolutionary scenario.

The review analyzes the major foreign publications on the iron exchange in mycobacteria for the recent years. The issues of iron absorption by tuberculous mycobacteria, its preservation and regulation of their metabolism have been reviewed. Deeper and more detail description of the above process will provide new opportunities for therapeutic interventions into it and assist in development of new tuberculosis treatment techniques.

The study included 28 patients with pulmonary tuberculosis and a possible postoperative hemoglobin level of less than 120 g/l. For the prevention of postoperative anemia it is used recombinant human erythropoietin alpha and iron (III) hydroxide sucrose complex. Hemoglobin levels were monitored for 4 weeks after surgery and it is estimated the need for blood transfusions. Use of recombinant human erythropoietin and iron sucrose in patients with pulmonary tuberculosis increases basic hematological parameters as compared with the control group, and reduces the risk of postoperative anemia.

The study included 28 patients with pulmonary tuberculosis and a possible postoperative hemoglobin level of less than 120 g/l. For the prevention of postoperative anemia it is used recombinant human erythropoietin alpha and iron (III) hydroxide sucrose complex. Hemoglobin levels were monitored for 4 weeks after surgery and it is estimated the need for blood transfusions. Use of recombinant human erythropoietin and iron sucrose in patients with pulmonary tuberculosis increases basic hematological parameters as compared with the control group, and reduces the risk of postoperative anemia.

Концепция существования множественных (смешанных) туберкулезных инфекций получает все большее признание.

Comparison of the state of 83 patients with histologically confirmed sarcoidosis observed with a 10 year interval revealed remission in 47% of the cases. The main factors having negative effect on prognosis of the disease included extrapulmonary symptoms, the use ofcorticosteroids (at all stages, especially at stage I and in Lofgren syndrome) and antituberculosis drugs, positive TB test. Risk factors of relapses were stage II sarcoidosis, the use of systemic corticosteroids in patients with Lofgren syndrome and antituberculosis drugs, initially low FEV1/FVLC ratio and the number of lymphocytes in peripheral blood.

The study included 22 patients with pulmonary tuberculosis and presumptive hemoglobin level post surgery of less than 120 g/l. For the prevention of postoperative anemia was used the recombinant human erythropoietin alpha and iron (III) hydroxide sucrose complex. Within four weeks level of hemoglobin after surgery and the need for blood transfusions was accessed. Use of recombinant human erythropoietin and iron sucrose in patients with pulmonary tuberculosis increases basic hematological parameters as compared with the control group, and reduces the risk of postoperative anemia.

The article is dedicated to the study of occurrence, characteristics and drug resistance trends among patients with TB relapses in Ryazan region. We have shown a tendency to MDR and simultaneous drug resistance share increase in the ratio to the three anti-TBdrugs of the 1st line, as well as a tendency to monoresistance share decrease at the relapse time as compared with the moment of the initial disease detection. It has been found out that the period before drug-resistant TB relapse emerging is with certainty shorter than that before the relapse uprise of the TB generated by the drug-sensitive mycobacteria tuberculosis.

In the study reported a significant decrease in quality of life for all indicators SF-36 questionnaire in patients co-infected with tuberculosis and chronic viral hepatitis, compared with healthy subjects. Chronic hepatitis from TB patients lead to a change in role functioning and pain perception, which is an additional factor that significantly reduces quality of life of patients with respiratory tuberculosis.

Summary. A multicenter (12 centers) retrospective analysis of health status of 83 sarcoidosis patients in time of diagnosis and after 10 years of treatment has been performed. In 10 years after diagnosis, 47 % of the patients had complete remission of pulmonary manifestations; mean forced spirometric values have not reduced in 10 years (excluding patients initially treated with anti-TB drugs). Patients treated with systemic steroids initially or during 10 yrs were less likely to have the complete remission (36.5 %) and more likely to have recurrent sarcoidosis course (57.1 %) compared to those not treated with systemic steroids. Pentoxifylline administration positively influenced the remission rate (71.4 %) and relapse rate in patients who had not received immunosuppressive therapy (28.6 %). A tendency has been found to positive effects of essential phospholipids on relapse rate and remission rate in sarcoidosis. Anti-TB therapy or treatment of sarcoidosis patients in TB centers negatively influenced the outcome of sarcoidosis. The results disclose an urgent need to imply new approaches to treatment of sarcoidosis, eg. anti-TNF-α drugs.

Summary. A multicenter (12 centers) retrospective analysis of health status of 83 sarcoidosis patients in time of diagnosis and after 10 years of treatment has been performed. In 10 years after diagnosis, 47 % of the patients had complete remission of pulmonary manifestations; mean forced spirometric values have not reduced in 10 years (excluding patients initially treated with anti-TB drugs). Patients treated with systemic steroids initially or during 10 yrs were less likely to have the complete remission (36.5 %) and more likely to have recurrent sarcoidosis course (57.1 %) compared to those not treated with systemic steroids. Pentoxifylline administration positively influenced the remission rate (71.4 %) and relapse rate in patients who had not received immunosuppressive therapy (28.6 %). A tendency has been found to positive effects of essential phospholipids on relapse rate and remission rate in sarcoidosis. Anti-TB therapy or treatment of sarcoidosis patients in TB centers negatively influenced the outcome of sarcoidosis. The results disclose an urgent need to imply new approaches to treatment of sarcoidosis, eg. anti-TNF-α drugs.

The given article is dedicated to the study of occurrence, characteristics and drug resistance trends among patients with TB relapses in Ryazan region. We have shown a tendency to MDR and simultaneous drug resistance share increase in the ratio to the three antituberculous preparations of the 1st line, as well as a tendency to monoresistance share decrease at the relapse time as compared with the moment of the initial disease detection. It has been found out that the period before drug-resistant TB relapse emerging is with certainty shorter than that before the relapse uprise of the TB generated by the drug-sensitive mycobacteria tuberculosis.

The article is devoted to drug-resistant tuberculosis in the Ryazan region. There is a tendency to the increase of the amount of tubercular patients among women of middle ages. It is stated that in the period from 1999 to 2007 mycobacteria’s structure of drug-resistance has not changed considerably. The exception was a dramatic increase of cases with simultaneous drug-resistance to the four first-line antibiotics. The direct interdependence between the character of drug-resistance and the speed and intensity of tuberculosis microorganisms growth has not been found yet.