The goal of this study was to see association between angeotensin-convertion enzyme (ACE) gene polymorphism, angeotensin II type 1 receptor (ATR 1 ), apoproteine E (APO E), apolipoprotein CIII (APO CIII), methylentetrahydrofolate reductase (MTHFR), fibrinogen (Fb), also endothelial NO-synthesis gene polymorphism (NOS3), and stroke frequency in patients suffering from AH (Arterial Hypertension) (n=41). Also to study the influence of these genes polymorphism on the characterizing parameters of AH (arterial hypertension). Conducted study shown that stroke frequency in patients with AH (arterial hypertension) associated with A1166C ATR 1 gene polymorphism, G-455A Fb gene polymorphism and C677T MTHFR gene polymorphism. And at the same time high risk markers and C- allele of ATR 1 gene and AA genotype of Fb-gene, and protection part in stroke origin in AH (arterial hypertension) patients play A-allele and genotype AA of ATR 1 gene, CC genotype of MTHFRg gene. Also figured out that patients with I/D and DD-genotype of ATR -gene, AC and CC genotypes of ATR 1 gene, TT and CT genotypes of MTHFR gene, AA-genotype of Fb, authentically valuable meaning have parameters of functional condition of cardio-vascular system and metabolic status which determines risk degree of stroke in AH-patients.