Dielectrophoresis (DEP) is a promising label-free technique for bioparticle manipulation, offering significant potential for diagnostic application such as isolation and trapping of cancerous CCRF-CEM cells. The efficacy of DEP trapping is critically dependent on the interaction between the cell’s dielectric properties and the spatial gradient of the squared electric field (∇|E2|), which is governed by electrode geometry. This study conducts a comparative evaluation, via finite element method (FEM) analysis, to quantify the positive dielectrophoresis (pDEP) force exerted on CCRF-CEM cells. Four distinct electrode configurations were analyzed: parallel (rectangular, triangular, cylindrical) and interdigitated. Based on a single-shell model for CCRF-CEM cells within a low-conductivity buffer, the Clausius-Mossotti factor was determined at 4.6 MHz, confirming a strong pDEP response that attracts cells to high-field regions. Results demonstrate that the pDEP force scales quadratically with applied voltage and is significantly enhanced by reducing the electrode gap. At a standardized 25 Vpp and 100 μm gap, the interdigitated configuration generated the highest maximum pDEP force, substantially exceeding the parallel rectangular, triangular, and cylindrical designs. Furthermore, the interdigitated geometry produced the most extensive and uniform high-force zones along the electrode edges, creating a superior trapping area. This comparative evaluation provides quantitative guidelines for optimizing electrode design, identifying the interdigitated configuration as the most effective for developing high-efficiency microdevices for CCRF-CEM cell trapping.

Dye Sensitized Solar Cell (DSSC) is the third generation of solar cells. DSSC is formed by sandwich structure, there are five parts: ITO glass (Indium Tin Oxide) as substrate; TiO2 as semiconductor material; dye (chlorophyll-turmeric-mangosteen) as an electron donor; gel electrolyte as electron transfer and active carbon as a catalyst in the counter electrode. The synthesis of nanometer-sized TiO2 powder is obtained by coprecipitation method. From the research that has been done, the efficiency of DSSC with 10 µm TiO2 layer thickness bigger than 20 µm and 30 µm layer thickness. The DSSC efficiency result is 0.25% for 10 µm TiO2 layer thickness , 0.143% for 20 µm TiO2 layer thickness, and 0.195% for 30 µm TiO2 layer thickness.

The fabricated 3D-printed bolus with 5 mm thick PLA and TPU materials was successfully used to analyze the air gap, relative electron density ( RED), and mass attenuation coefficient values for Post-Mastectomy Breast Cancer Radiation Therapy (PMRT). The 3D bolus was designed using 3D-Slicer Segment Editor software according to the thickness used, then smoothed and finished using Autodesk Meshmixer software, and printed on a 3D Creality printer. The air gap value was then analyzed by taking images from the phantom and 3D-printed bolus on a CT-Scan, then processed on Radiant DICOM, and the air gap value for the two 3D bolus materials was obtained. Analysis of two 3D bolus materials, PLA and TPU, showed that TPU is more suitable for bolus use in postmastectomy breast cancer cases based on its material properties. In addition, TPU is also better in terms of the air gap value because it has a smaller air gap, an RED value that is almost close to that of breast tissue, and better mass attenuation. Therefore, the recommended 3D-printed bolus material is TPU with a thickness of 5 mm as a tissue substitute for postmastectomy breast cancer cases.

Dye-sensitized Solar Cell (DSSC) is a dye sensitized solar cells are formed by a sandwich structure where there are five parts include: glass ITO (Indium Tin Oxide) as a substrate; TiO2 as a semiconductor material; chlorophyll dye as an electron donor; electrolyte as electron transfer. Nanometer-sized TiO2 powder obtained through synthesis by coprecipitation method. Measurements were taken at the power of 100 mW/cm2. The results of the efficiency of DSSC using active carbon as a catalyst in the reference electrode, produces a larger percentage than black carbon and graphite, which is of 0.05% for active carbon, black carbon to 0.032%, 0.029% for graphite.

The image reconstruction for two-dimensional high-speed Electrical Impedance Tomography (EIT) has been successfully studied with multi-frequency current injection. The aim of this study is to get the best image reconstruction under the influence of multi-frequency current injection of this EIT system. In this method, we used current injection at 1 mA with varies of frequency in the range 10 to 50 kHz injected at the practical phantoms with 16 electrodes. Polyvinyl chloride (PVC) cylinder was put in the practical phantom as the anomaly. Then, The boundary voltage of the practical phantom was measured by the voltage measurement circuit. After that, it processed in the computer with Gauss-Newton Algorithm to got image reconstruction. The result showed that the best image reconstruction was achieved at 10 kHz of frequency current injection. The best image reconstruction had more accuracy of shape, position and electrical properties of an anomaly in boundary phantom than another image reconstruction result .

Indonesia salah satu negara terdampak Coronavirus disease 2019, sejak saat itu telah diterapkan pembelajaran daring interaktif dengan memanfaatkan beberapa platform seperti Google Classroom, dan Zoom. Saat ini guru dituntut untuk menyiapkan metode pembelajaran tatap muka yang tidak monoton dan handal dalam penguasaan teknologi serta dapat menampilkan pembelajaran yang interaktif untuk para siswa. Berdasarkan permasalahan tersebut perlu disadari bahwa guru memiliki peran yang sangat penting dalam suksesnya pembelajaran dan pendidikan. Oleh karena itu tim pengabdi dari Departemen Fisika ITS memberikan pelatihan kepada guru mengenai e-learning melalui program pengabdian kepada masyarakat di SDN Candimulyo 3 Madiun Jawa Timur. Tim pengabdi memberi pelatihan mengenai bagaimana cara menyampaikan materi dengan menarik menggunakan aplikasi gratis yaitu PhET-Colorado dan menyampaikan bagaimana cara membuat soal evaluasi untuk siswa secara menyenangkan menggunakan Quizizz. Guru-guru telah melakukan praktik pembuatan soal evaluasi dengan media Quizizz dengan baik. Kemudian soal tersebut juga telah disampaikan di kelas dengan hasil yang telah sesuai dengan arahan tim pengabdi.

This study presents a novel biosensor for detecting CCRF-CEM cells, derived from a T lymphoblastoid cell line, featuring intricate surface modification techniques. The fabrication process involves thin film deposition, electropolishing and dual anodization to create an anodic aluminum oxide template, followed by DC sputtering deposition to produce gold (Au) thin film/silver (Ag) nanodots and an Ag thin film/Au nanodots electrodes. Characterization using scanning electron microscopes (SEM), energy-dispersive X-ray spectroscopy (EDX), and X-ray diffraction (XRD) confirms electrode suitability for biosensing applications. Surface modification with aptamer Sgc8c and bovine serum albumin enables specific binding of CCRF-CEM cells while minimizing non-specific interactions. Electrochemical characterization via cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) reveals the biosensor's sensitivity, selectivity, and reproducibility. The Au thin film/Ag nanodots electrode emerges as the most promising choice, exhibiting exceptional sensitivity (limit of detection (LOD) = 16 cell/10 mL), reproducibility, and selectivity for CCRF-CEM cells. This work highlights the importance of tailored surface development in biosensor design and lays the groundwork for highly sensitive and selective biosensors with potential applications in disease diagnosis and therapeutic monitoring.

Leukemia is one of the ten types of cancer that causes the biggest death in the world. Compared to other types of cancer, leukemia has a low life expectancy, so an early diagnosis of the cancer is necessary. A new strategy has been developed to identify various leukemia biomarkers by making blood cancer biosensors, especially by developing nanomaterial applications so that they can improve the performance of the biosensor. Although many biosensors have been developed, the detection of leukemia by using nanomaterials with electrochemical and optical methods is still less carried out compare to other types of cancer biosensors. Even the acoustic and calorimetric testing methods for the detection of leukemia by utilizing nanomaterials have not yet been carried out. Most of the reviewed works reported the use of gold nanoparticles and electrochemical characterization methods for leukemia detection with the object of study being conventional cancer cells. In order to be used clinically by the community, future research must be carried out with a lot of patient blood objects, develop non-invasive leukemia detection, and be able to detect all types of blood cancer specifically with one biosensor. This can lead to a fast and accurate diagnosis thus allowing for early treatment and easy periodic condition monitoring for various types of leukemia based on its biomarker and future design controlable via internet of things (IoT) so that why would be monitoring real times.

Electrical impedance tomography (EIT), as a non-ionizing tomography method, has been widely used in various fields of application, such as engineering and medical fields. This study applies an iterative process to reconstruct EIT images using the simultaneous algebraic reconstruction technique (SART) algorithm combined with K-means clustering. The reconstruction started with defining the finite element method (FEM) model and filtering the measurement data with a Butterworth low-pass filter. The next step is solving the inverse problem in the EIT case with the SART algorithm. The results of the SART algorithm approach were classified using the K-means clustering and thresholding. The reconstruction results were evaluated with the peak signal noise ratio (PSNR), structural similarity indices (SSIM), and normalized root mean square error (NRMSE). They were compared with the one-step gauss-newton (GN) and total variation regularization based on iteratively reweighted least-squares (TV-IRLS) methods. The evaluation shows that the average PSNR and SSIM of the proposed reconstruction method are the highest of the other methods, each being 24.24 and 0.94; meanwhile, the average NRMSE value is the lowest, which is 0.04. The performance evaluation also shows that the proposed method is faster than the other methods.

Radiation therapy treatment for post-mastectomy breast cancer usually requires a bolus to raise the surface dose to a certain level. Bolus is a compensatory material that has properties such as soft tissue or water. Therefore, this study will evaluate the potential of using bolus and without bolus in post-mastectomy breast cancer cases. This study aims to analyze the percentage surface dose (PSD) on the solid water slab phantom, dose-volume histogram (DVH), profile dose, and surface dose in Postmastectomy Radiation Therapy (PMRT) cases with and without using a bolus made of silicone rubber with a thickness of 0.5 cm. The methods used in this study include measuring surface dose using bolus and without bolus on a solid water slab phantom with the TRS 398 protocol, making an Intensity-modulated radiation therapy (IMRT) planning system in 5 fields with angles of 30 ̊, 60 ̊, 230 ̊, 260 ̊and 320 ̊. Then analyzed DVH, dose profile, and surface dose using bolus and without bolus. Finally, verification of the plans that have been made is done using EBT3 film placed at 3 points (isocenter, right, and left). The results showed that DVH with bolus and without bolus met the recommendations of the International Commission on Radiation Unit (ICRU) 62, and organ at risk (OAR) still met the tolerance limit. Percentage of surface dose reached to 80,02 % and 29,75 % respectively for with and without bolus. The surface dose in PMRT increased up to 35%. Moreover, a bolus can increase the dose to the surface very well when the tumor cells are located on the surface compared to without a bolus.

Sertifikasi halal adalah serangkaian proses untuk memperoleh sertifikat halal, sedangkan sertifikat halal Majelis Ulama Indonesia (MUI) sendiri adalah fatwa tertulis Majelis Ulama Indonesia yang menyatakan kehalalan suatu produk sesuai dengan syariat Islam. Pendampingan sertifikasi halal dilakukan pada Usaha Mikro Kecil dan Menengah (UMKM) yang berada pada Sentra Wisata Kuliner (SWK) Convention Hall dan UMKM di daerah Benowo. Tahapan pendampingan Sertifikasi Halal di Convention Hall meliputi 5 tahap yaitu musyawarah bersama pengurus Sentra Wisata Kuliner Convention Hall Surabaya, pendataan UMKM yang mengikuti program sertifikasi halal, pendampingan dalam melakukan pengisian website oss dan sihalal, proses verifikasi dan validasi (verval) di tempat produksi setiap UMKM, dan terakhir proses penerbitan sertifikat halal oleh Komite Fatwa Badan Penyelenggara Jaminan Produk Halal (BPJPH) Jawa Timur. Sedangkan tahapan pendampingan Sertifikasi Halal di Benowo meliputi 4 tahap yaitu sosialisasi dan pendataan UMKM yang mengikuti program sertifikasi halal, pendampingan dalam melakukan pengisian website oss dan sihalal, proses verifikasi dan validasi (verval) di tempat produksi setiap UMKM, dan terakhir proses penerbitan sertifikat halal oleh Komite Fatwa BPJPH Jawa Timur. Untuk sentra wisata kuliner Convention Hall Surabaya hanya 4 UMKM yang telah masuk proses komite fatwa. Sedangkan, UMKM di wilayah Benowo total ada 10 UMKM atau keseluruhan UMKM telah berhasil masuk ke proses komite fatwa dan menunggu sertifikat halal terbit.

Ag and AgNO film were fabricated through sputter deposition on indium tin oxide (ITO) conductive glass. Electrochemical detection using cyclic voltammetry (CV) was carried out for low albumin levels in blood as a parameter of cancer patients. This study aims to determinate low albumin level as a biomarker cancer. Albumin adsorption on the Agfilm/ITO and AgNOfilm/ITO was also investigated to determine the level of sensitivity of both electrodes. Analysis of the CV measurements indicated that the Agfilm/ITO electrode was more sensitive compared to the AgNOfilm/ITO electrode, with a sensitivity value of 4.564 µA M-1cm-2 for the Agfilm/ITO electrode and 2.123 µA M-1cm-2 for the AgNOfilm/ITO electrode. The testing of albumin levels in blood within a range of low concentration levels between 10-1 and 10-8 g/dL indicated a detection limit of 10-9 g/mL. The selectivity of Ag electrodes was found to be very good for other interfering molecules such as urine, glucose, and lysozyme. The results of the modeling of electric field and magnetic field distribution showed that the Agfilm/ITO electrode possessed larger values than the AgNOfilm/ITO electrode. From this analysis, it can be concluded that the electrode modified with micro-sized Ag achieved more effective results than the electrode modified with AgNO. This sensor can determine low albumin level as a blood cancer biomarker. This sensor holds great promise for use in real samples in the future. HIGHLIGHTS Early detection with albumin biomarkers before metastasis cancer The testing of albumin levels with Cyclic Voltammetry and Electric Impedance Spectroscopy in the cancer within a wide range of low concentration levels (10-1 - 10-8) indicated a detection limit of 10-9 g/mL. The total mass of adsorbed BSA in electrode surface is more higher (281 mgm-2) than previous study. The Agfilm/ITO electrode exhibited high sensitivity and long-term stability for future applications. GRAPHICAL ABSTRACT

The fabrication of a ZnO/Au nanosquare-array electrode was successfully carried out for the detection of glucose concentration in biomedical applications. The fabrication of the ZnO/Au nanosquare array using an ultra-thin alumina mask (UTAM) based on the imprinted anodic aluminum oxide (AAO) template and the direct current (DC) sputtering method was able to produce a very well-ordered nanosquare arrangement with a side size of 300 nm and a thickness of 100 nm. Tests were done to evaluate the performance of the electrode by means of cyclic voltammetry (CV) which showed that the addition of glucose oxidase (GOx) increased the sensitivity of the electrode up to 1180 ± 116 μA mM−1cm−2, compared with its sensitivity prior to the addition of GOx of 188.34 ± 18.70 mA mM−1 cm−2. A iox/ired ratio equal to ~1 between the peaks of redox reactions was obtained for high (hyperglycemia), normal, and low (hypoglycemia) levels of glucose. The ZnO/Au nanosquare-array electrode was 7.54% more sensitive than the ZnO/Au thin-film electrode. Furthermore, finite-difference time-domain (FDTD) simulations and theoretical calculations of the energy density of the electric and magnetic fields produced by the ZnO/Au electrode were carried out and compared to the results of CV. From the results of CV, FDTD simulation, and theoretical calculations, it was confirmed that the ZnO/Au nanosquare array possessed a significant optical absorption and that the quantum effect from the nanosquare array resulted in a higher sensitivity than the thin film.

The fabrication of silver (Ag) and gold (Au) thin film electrodes was successfully carried out using the DC sputtering deposition method. These thin film electrodes were able to detect the increase in serum albumin concentration that was used as a prognostic factor for leukemia. The simulation and the optical experimental analysis show that an increase in BSA concentration can increase the absorbance peak observed at a wavelength of 435 nm on hypoalbumin medium and 470 nm on normal concentration of serum albumin medium. The performance of the electrodes was electrochemically tested, in which it was shown that a decrease in oxidation and reduction peaks occurred with respect to an increase in BSA concentration. An oxidation peak was observed at a voltage of 0.5 V for the Ag thin film. For the Au, Au/Ag, and Ag/Au thin films, an oxidation peak was observed at a voltage of 1.0 V. The limits of detection (LODs) of the Ag, Ag/Au, Au, and Au/Ag thin films were 0.56, 0.24, 0.64, and 0.36 g/dL, respectively. Therefore, based on both the electrochemical and optical analysis, the Ag/Au thin film possessed the highest potential for prognosis monitoring of leukemia compared with the other Ag and Au thin films.

3D printing technology was capable of fabricating phantoms to enhance quality assurance in radiation therapy. The ideal phantom has properties equivalent to the real tissue. However, 3D Printing has the limits to mimicking the attenuation properties of various tissues because during 3D printing there can be only one type of material. The purpose of this study was to evaluate the effect of infill percentage and infill patterns of 3D printing technology to simulate various types of tissue. This study used 25 samples measuring 5 × 5 × 1 cm3 from PETG material. The 20 samples were printed using variations infill percentages from 5 - 100% and the infill pattern in lines. The five samples were then printed with the infill percentage constant at 50% and used the infill pattern triangles, grid, gyroid, octet, and concentric. We used Computed Tomography (CT) to determine the Hounsfield Unit (HU) value for each sample and evaluated the suitability of each sample for phantom applications in radiation therapy and radiology. However, none of the samples was able to simulate compact bone. As a result, we found that PETG material could simulate the properties of soft tissue, fat, lung, kidney, liver, pancreas, and spongy bone. Thus, the study had shown promising potential for the fabrication of the anthropomorphic phantom of radiation therapy.

Sertifikasi halal self-declare merupakan wujud komitmen pemerintah yang dijabarkan oleh BPJH untuk memfasilitasi sertifikasi halal non-risk menjelang tahun 2024. Produk UMKM memiliki relatif sederhana terhadap bahan dan proses produksi, namun demikian pengolahan dan proses pembuatannya tetap rentan terhadap titik kritis yang tetap harus diberi penjelasan. Dari 20 pelaku UMKM peserta pendampingan dilakukan dengan cara tatap muka, wawancara secara langsung dan tidak langsung untuk mengetahui tentang pelaksanaan 1) kebijakan halal; 2) bahan dan melaksanakan prosedur terhadap bahan yang digunakan untuk produksi; 3) melaksanakan prosedur proses produk halal; 4) serta melaksanakan audit internal secara berkala. Tujuan pemantauan dan edukasi kepada UMKM ini adalah menguatkan dan memberikan penyuluhan terhadap 4 kriteria dokumen SJH yang diperlukan dalam mengurus sertifikasi halal tipe self-declare. Target dari kegiatan ini adalah agar jenis produk-produk UMKM ini dapat melakukan kesiapan secara berkelanjutan pre-sertifikasi sampai pasca-sertifikasi dalam melaksanakan tatacara melaksanakan prosedur halal untuk produk ini. Dari ananlisa faktual 3 UMKM telah mendapatkan sertifikasi halal, 6 UMKM telah kadaluarsa sertifikasi halalnya dengan masa sertifikat 2 tahun dan akan/sedang mengajukan sertifikasi halal self-declare, sedangkan 11 UMKM belum pernah mengajukan sertifikasi halal.