Introduction . The adaptive overload of the central nervous system, caused by occupational stress, leads to the disruption of complex operational activities in the ambulance station workers and an increasing number of errors in medical decision-making towards the end of the work shift. Aim . To assess the level and prevalence of changes in the work of the central nervous system (CNS) under the influence of occupational stress. Materials and methods . The study involved 35 workers (medical and nursing staff) of ambulance station (19 men and 16 women aged 20 to 55 years). Electroencephalogram (EEG) was recorded at rest for 3 minutes, according to international scheme 10-20 in six leads: F3, F4, T3, T4, P3, P4. The following rhythmic activity indicators were used: THETA rhythm (4–8 Hz), ALPHA rhythm (8–12 Hz), BETA rhythm (BETA, 12–25 Hz) and their ratios. Results and discussion . When analyzing the overall activity, there is a decrease in all the studied parameters. At the same time, THETA, BETA and the total power of all ranges showed significant dynamics. In spatial analysis, the most noticeable decrease in activity in the frontal lobes (F3, F4) is responsible for motor behavior (premotor area of the cortex), executive functions (behavior control, inductive reasoning, planning), short-term and spatial memory, attention (spatial and motor). The decrease in activity in the temporal (T3, T4) and parietal (P3, P4) departments is observed only in some indicators. Conclusions . Professional workload during the 24 hour shift has a predominant effect on the activity of the frontal lobes, reducing the ability to control and plan complex (precise) motor functions, visual-spatial attention and planning abilities. These mechanisms are key to the professional work of the personnel of the emergency medical service and determine the number of errors.
Introduction. The adaptive overload of the central nervous system, caused by occupational stress, leads to the disruption of complex operational activities in the ambulance station workers and an increasing number of errors in medical decision-making towards the end of the work shift.Aim. To assess the level and prevalence of changes in the work of the central nervous system (CNS) under the influence of occupational stress.Materials and methods. The study involved 35 workers (medical and nursing staff) of ambulance station (19 men and 16 women aged 20 to 55 years). Electroencephalogram (EEG) was recorded at rest for 3 minutes, according to international scheme 10-20 in six leads: F3, F4, T3, T4, P3, P4. The following rhythmic activity indicators were used: THETA rhythm (4–8 Hz), ALPHA rhythm (8–12 Hz), BETA rhythm (BETA, 12–25 Hz) and their ratios.Results and discussion. When analyzing the overall activity, there is a decrease in all the studied parameters. At the same time, THETA, BETA and the total power of all ranges showed significant dynamics. In spatial analysis, the most noticeable decrease in activity in the frontal lobes (F3, F4) is responsible for motor behavior (premotor area of the cortex), executive functions (behavior control, inductive reasoning, planning), short-term and spatial memory, attention (spatial and motor). The decrease in activity in the temporal (T3, T4) and parietal (P3, P4) departments is observed only in some indicators.Conclusions. Professional workload during the 24 hour shift has a predominant effect on the activity of the frontal lobes, reducing the ability to control and plan complex (precise) motor functions, visual-spatial attention and planning abilities. These mechanisms are key to the professional work of the personnel of the emergency medical service and determine the number of errors.
Introduction. In the research literature, there have been recorded instances of imbalance of interleukins and tumour necrosis factors in the cervix tissues, endocervical mucus, suggestive of the potential feasibility of the use of immunomodulatory therapy.Purpose of the study. To assess the effectiveness of the use of the domestic drug allokin-alpha in the treatment of high-risk HPV infection (HPV) in patients of reproductive age, without elimination of the virus within more than 6–12 months and planning pregnancy.Materials and methods. The study included 60 patients of reproductive age with chronic HPV carriage – BP infection. They are represented in the study by two groups: 1st: 30 people in whose therapy allokin-alpha was not used (control group); and 30 patients without HPV BPV elimination in terms of more than 6–12 months, planning pregnancy and taking the domestic cytokiton-like immunomodulator allokin-alpha.Results. Spontaneous pregnancy occurred in 2/30 (6.7%) in the group without immunomodulator and in 9/30 patients in the group with allokin-alpha (30%) cases (c² = 5.45; p = 0.02; OR = 6.0 [1.17–30.72])Conclusion. The sustained virological response that we have achieved indicates the advisability of the use of allokin-alpha, a domestic immunomodulator of natural origin, in patients with high-risk chronic HPV infection and reproductive planning.
МОДЕЛЬ ПРОГНОЗИРОВАНИЯ ПРЕЖДЕВРЕМЕННОЙ ОТСЛОЙКИ НОРМАЛЬНО РАСПОЛОЖЕННОЙ ПЛАЦЕНТЫ ПРИ НЕДОНОШЕННОЙ БЕРЕМЕННОСТИЛ. И. Анохова 1 , Т
Materials and methods. This retrospective case-control study enrolled 50 women with severe preeclampsia and 50 control women with spontaneous singleton pregnancy. Median age of women ranged from 20 to 35 years. All women did not have a history of hypertension, autoimmune, metabolic, renal, or cardiac diseases, and preeclampsia before this pregnancy. We have analyzed χ2, odds ratio (OR) and its 95% confidence intervals (95% Cl). Results. We found significant association between maternal systemic infectious and severe preeclampsia (OR = 49.6; 95% Cl 13.05-188.64). The risk of severe preeclampsia were significantly lower in patients with local infections of the lower genital tract (OR = 4.5; 95% Cl 1.49-6.71). Asymptomatic bacteriuria is associated with the highest risk of severe preeclampsia (OR = 17.0; 95% Cl 4.66-61.81). Acute gravidarum pyelonephritis showed lower association with severe preeclampsia (OR = 5.4; 95% Cl 1.69-10.54). We did not observe increased risk of severe preeclampsia with acute respiratory infections (OR = 2.0; 95% Cl 0.71-4.69). Acute non-specific bacterial vaginitis and acute candidiasis vulvovaginitis were found to be risk factors of severe preeclampsia (OR = 6.7; 95% Cl 1.90-11.02 and OR = 4.3; 95% Cl 1.45-9.99 respectively). Cytomegalovirus infection (2 %), toxoplasmosis (2 %), Chlamydia trachomatis cervicitis (4 %), acute Trichomonas colpitis (2 %) and bacterial vaginosis (4 %) were found only in patients with severe preeclampsia. Conclusion. Our data support that acute maternal infection is associated with an increased risk of severe preeclampsia in healthy women with singleton pregnancy. Systemic inflammatory response might be the main potential mechanisms related to infections and enhanced development of severe preeclampsia. Further research is required to elucidate the underlying mechanism of this association.
The identification of the immune system disorders along with the impact on the causative agent and correction of such disorders is of great importance in the therapy of patients with endometritis. It has been established that the infectious agents are eliminated by the phagocytic system cells, therefore the optimal choice for the activation of anti-infective immunity are the immunomodulators acting on the monocyte-macrophage system cells. Use of immunomodulators: recombinant human interleukin-2 (Roncoleukin®, IL-2) and Interferon alfa-2b + Taurine + Benzocaine (Genferon®) in combination with the standard therapy showed its safety and efficiency in treating patients with endometritis after caesarean section.
ПОЛИМОРФИЗМ ГЕНОВ ПРОВОСПАЛИТЕЛЬНЫХ ЦИТОКИНОВ У ЖЕНЩИН С ПРЕЖДЕВРЕМЕННЫМИ РОДАМИЛ. И. Анохова, Т
В работу включены 206 женщин, родивших недоношенных детей без признаков ЗРП (1-я группа сравнения) и 70 пациенток, родивших детей преждевременно, с ЗРП, составившие 2-ю группу сравнения. При преждевременных родах с плацентарными нарушениями и ЗРП выявлены статистически значимые гемореологические нарушения: снижение показателя гематокрита (р=0,0025), уменьшение содержания эритроцитов (р<0,001), снижение СОЭ (р=0,004) с активацией сосудисто-тромбоцитарного гемостаза и изменениями коагуляционного потенциала: удлинение АЧТВ (р<0,001), понижение МНО (р=0,012), характерные для 1-й фазы синдрома диссеминированного внутрисосудистого свертывания крови, чаще встречались во второй группе сравнения и отнесены к предикторам ЗРП. Количественные признаки, в значениях которых обнаружены статистически значимые различия, могут быть использованы в качестве потенциальных прогностических факторов (предикторов). Обнаруженные, и выделенные как предикторы развития ЗРП, межгрупповые различия в медианных гемореологических количественных показателях открывают новый подход в прогнозировании задержки роста плода в сроки преждевременных оперативных родов.
КОЛОНКА РЕДАКТОРА Дорогие коллеги!Основная тема выпуска -проблема родовспоможения.На страницах этого номера мы обсуждаем наиболее актуальные вопросы акушерства: особенности течения беременности и родов в возрастном аспекте, вопросы истмико-цервикальной недостаточности и преждевременного разрыва плодных оболочек, акушерских кровотечений, плацентарной недостаточности, задержки роста плода, асфиксии новорожденного
Aim: To develop a model for prediction of intrauterine growth retardation in preterm pregnancy. Materials and Methods: We collected 264 observations and used a logistic regression to calculate the receiver operating characteristic (ROC) curve and area under the curve. Six independent variables were ranked according to the strength of their relationship with the dependent variable. Results: We found that smoking was one of the causes of intrauterine growth restriction, having the highest impact on intrauterine growth retardation. Past medical history of gynecological diseases, complicated pregnancies, abortions, miscarriages, or preterm birth as well as placental insufficiency also were the significant risk factors of intrauterine growth retardation. Moreover, F7 gene 10976 G>A, FGB gene 455 G>A, and ITGB3 gene 1565 T>C polymorphisms were also identified as risk factors. Area under the ROC curve was 0.792 that testified the fair predictive value of the model. Conclusions: Our model can be used for prediction of intrauterine growth retardation.
We studied polymorphisms of candidate genes of hemostasis disorders in 205 pregnant women after having A(H1N1) pdm2009 influenza during pregnancy and in 75 pregnant women who didn't have acute respiratory viral infections during pregnancy. Pregnant women with influenza were more often carriers of mutant alleles F2, genotypes F7:0976GA and F13:W3G> . Severe course of influenza is associated with genotypes F7:0976GA and PAI-1:4G4G. It was revealed that polymorphisms of genes F7:0976G>A, F13:103G>T and PAI-1:6755G>4G can be molecular predictors of complicated course of A(HlNl)pdm09 influenza in pregnant women.
We conducted epidemiological research of WHO record for the estimation of prevalence and characteristics of infertility in young women living in Zabaykalsky District. The research included 2932 women of 18-35 years, 731 of them had infertility. Frequency of infertility exceeds 15% critical level, determined by WHO, and reaches 24,9 % (22,3 % - in town, 25,8 % - in countryside). Secondary infertility appears more often that primary one (54,2 % vs 45,8 %). 44,0 % of young infertile women don't plan pregnancy.
Abstract. An immune deficiency state, along with continuously increased intravascular coagulation, are shown to develop in puerperal women after Caesarian section complicated by endometritis. Complex therapeutic schedules aimed for endometritis treatment, including thymic peptides (thymalin or thymogen) are accompanied by more rapid correction of these disorders and favorable clinical effect. (Med. Immunol., 2011, vol. 13, N 2-3, pp 279-284)
The analysis was made of the content of proteins in inflammation acute phase in 100 healthy puerperants and 157 women with endometritis after cesarean section. The established disproportion in protein concentration during acute phase in healthy puerperants is considered as a female organism adaptive reaction to pregnancy and delivery. As for patients with endometritis, this condition testifies the compensatory resources stress, development of pathophysiological reactions of organism and intensity of local damages. The concentration of C-reactive protein and prealbumin in patients with endometritis provides an opportunity to forecast the degree of severity of course of disease.
