With the advancement of 5G communications, the Internet of Things (IoT), and wearable electronics, there has been an increasing demand for lightweight, flexible, and high-performance electromagnetic interference (EMI) shielding materials. In this study, AgNWs/TOCNF/CNTs* nanocomposite films with Janus structure were successfully prepared by vacuum-assisted filtration followed by hot pressing. The film consisted of a conductive silver nanowire (AgNWs) layer and a supporting TOCNF/CNTs* layer. Specifically, the electromagnetic shielding and mechanical properties were effectively enhanced by constructing a three-dimensional (3D) network within the TOCNF/CNTs* layer through ionic crosslinking between Ca2+ ions and carboxylate anions (-COO-). Comprehensive characterization demonstrated that the film possessed excellent mechanical strength (tensile strength of 93.92 +/- 3.20 MPa), superior electrical conductivity (67,114 S/m), outstanding EMI shielding effectiveness (EMI SET of 63.70 dB, EMI SEE/t exceeding 10,284 dB & sdot;cm2/g, and a shielding efficiency of 99.999957 %), as well as rapid Joule heating response under low voltage (2.0 V, reaching 115.60 degrees C within less than 6s). These properties underscore the film's strong potential for applications in portable electronics, aerospace, and military technologies.

Congenital biliary dilatation (CBD) in children remains a disease of enigmatic origin. Prevailing theories focusing on anomalous pancreaticobiliary ductal union (APBDU) fail to explain the critical anatomical hallmark of Type Ia CBD: the coexistence of a distal stenotic segment (DSS) and a proximal dilated segment (PDS). We aimed to define region-specific molecular landscapes to bridge this fundamental gap. We conducted label-free proteomic and histomorphometric analyses on distinct surgical specimens-cystic duct (CD: as the least-affected internal reference), DSS, and PDS-from pediatric CBD patients (n = 5 proteomics; n = 12 validation). Key findings were rigorously validated using multiplex immunofluorescence, immunohistochemistry, and functional enrichment. Proteomic profiling established DSS and PDS as biologically distinct pathological entities. While both segments shared severe epithelial dysfunction and mechanosensory ciliary loss, a profound molecular dichotomy emerged in smooth muscle remodeling. The DSS was characterized by robust ferroptosis-associated fibrosis (TFR1/α-SMA co-localization) and β-amyloid-associated neural degeneration. Conversely, the PDS exhibited marked muscular atrophy and wall tension failure (CALD1 upregulation). This regional proteomic atlas reveals a pronounced spatial dichotomy, calling into question the adequacy of traditional uniform disease models. These findings suggest that ferroptosis may contribute to distal stenosis and highlight potential therapeutic targets to mitigate fibrosis and improve long-term surgical outcomes.

Non-operative management is often used for complicated appendicitis, but the role of routine interval appendectomy (IA) remains debated. This systematic review and meta-analysis estimated the IA-based detection rate of appendiceal neoplasm in adults with complicated appendicitis and assessed age-stratified detection patterns among available IA cohorts. PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wanfang were searched from database inception to April 2026. Eligible studies reported histopathologically confirmed appendiceal neoplasms among adults undergoing IA after complicated appendicitis. Pooled detection rates were calculated using a random-effects model with Freeman–Tukey double arcsine transformation. Risk of bias was assessed using ROBINS-I V2 for observational studies and RoB 2 for randomized trials. Certainty of evidence was assessed using GRADE. Twelve studies including 1340 patients and 162 neoplasms were included. Among adults selected for IA and histopathological assessment, the pooled IA-based detection rate of appendiceal neoplasm was 12.2

OBJECTIVE:The existing extraoral approaches cannot meet the aesthetic requirements of the patients with subcondylar fractures well because of visible extraoral scars. Endoscopic-assisted intraoral approach is an aesthetic approach without visible extraoral scars, but it requires expensive equipment and has a steep learning curve, which precludes its use in most hospitals. This study aimed to explore open reduction and internal fixation (ORIF) of subcondylar fracture using a postauricular-groove approach without endoscopic assistant and to assess the aesthetic outcomes and complications. METHODS:This retrospective clinical study included 11 consecutive patients with subcondylar fractures who underwent ORIF using a postauricular-groove approach without endoscopic assistant between Jun 2017 and December 2025. The aesthetic outcomes and complications were evaluated. RESULTS:The mean satisfaction score (0-10) for aesthetic outcomes of incisions was 9.64 ± 0.67 (mean ± SD). Temporary facial nerve weakness was observed in one patient (9.1%), which resolved within 6 months postoperatively. Postoperative auricular anaesthesia was observed in one case(9.1%), and sialocele in another(9.1%). Both resolved within 6 months and 3 weeks postoperatively, respectively. CONCLUSION:It appears that ORIF of subcondylar fracture using a postauricular-groove approach without endoscopic assistant is viable and safe, and can meet the aesthetic requirements of patients well. More importantly, without the need for endoscopic assistant, it can be used in most hospitals.

Precision microdrilling of nickel-based superalloys requires simultaneous control of microhole accuracy, thermal damage, recast-layer formation, processing efficiency, and manufacturing cost. Coaxial waterjet-assisted laser drilling (CWALD) offers a promising route. This study reports the first systematic application of CWALD to the microdrilling of K4002 nickel-based superalloy. In the CWALD process, a focused laser beam was coaxially coupled into the core of a vertical laminar waterjet. Four process parameters were investigated: pulse frequency (kHz), laser pump current (A), waterjet velocity (m/s), and spot overlap ratio (%). Their effects on material removal rate (MRR), geometric precision, hole taper, entrance rough-band width, and recast-layer thickness were systematically characterized. The coaxial vertical waterjet facilitates bubble transport and dispersion while continuously flushing molten material and ablation products from the hole, thereby reducing bubble-induced scattering and improving drilling efficiency and dimensional accuracy. It also suppresses recast-layer formation, particularly at moderate single-pulse energy and high waterjet velocity. One-factor-at-a-time (OFAT) results showed that the average MRR was highest at 10kHz and lowest at 40kHz, whereas hole taper was lowest at 10kHz and highest at 30kHz. A waterjet velocity of 5.66m/s provided the best balance between MRR and entrance rough-band width, while the maximum MRR occurred at a spot overlap ratio of 90%. The OFAT experiments were followed by a 17-run response surface methodology (RSM) design to quantify parameter interactions and determine the optimal process parameter combination. The five response models achieved adjusted R2 values of 0.8522-0.9592. The optimal combination was 5kHz, 36A, 5.66m/s, and 90%. This study provides process guidance for fabricating high-quality microholes in K4002 nickel-based superalloy using CWALD and serves as a reference for process optimization in related CWALD microdrilling applications.

Epoxy-functional silicone resins are promising reactive modifiers for transparent hard coatings. However, their synthesis often faces challenges such as ring-opening of epoxy groups under acidic conditions or insufficient siloxane condensation. In this work, a weak base-catalyzed hydrolytic condensation method was developed to synthesize a series of soluble epoxy-functional MDQ and MTQ silicone resins, containing M/D/Q and M/T/Q siloxane units, respectively, with tunable molecular weight. K2CO3 was used as a mild catalyst to promote Si-O-Si network formation while preserving epoxy functionalities. The obtained silicone resins were introduced into a tetra-armed epoxy-functionalized phenylsiloxane (BBE-Ep4Si, BE) to fabricate transparent coatings through epoxy-anhydride curing. The incorporation of epoxy-functional silicone resins significantly improved the thermal stability and surface hardness of the coatings. The optimized coating exhibited the best overall performance, with a pencil hardness of 8H, an adhesion grade of 5B, a transmittance of 95.8% at 550 nm, a low surface energy of 27.92 mN m−1, and good anti-contamination and easy-cleaning properties. After 96 h of UV aging, the coating still maintained high visible-light transmittance of 92.3% at 550 nm and good hydrophobicity with a water contact angle of 99.5°. The optimized coating shows potential as a transparent protective layer for next-generation optoelectronic devices, including foldable displays, touch panels, and cover windows.

In this study, a novel magnetic carboxymethyl chitosan/graphene oxide composite aerogel (Fe3O4@PDA/CMC/GO) adsorbent was successfully synthesized and used to remove triphenylmethane dyes from aqueous solutions. The synthesized adsorbent was characterized by FT-IR, SEM, TEM, TG, XRD, VSM, and BET technology methods. The adsorption of triphenylmethane dyes (AF: acid fuchsin; CV: crystal violet; MG: malachite green,) on Fe3O4@PDA/CMC/GO aerogel was performed to optimize the parameters, including pH, initial dye concentration, adsorbent dose, adsorption time, and temperature. The adsorption mechanism explained by kinetic data shows that, compared with the pseudo-first-order kinetic model, the adsorption process of three triphenylmethane dyes is a pseudo-second-order kinetic model. The isotherm parameters confirm that the adsorption process follows multilayer adsorption on a heterogeneous surface, with maximum adsorption capacities of 425.9, 757.6, and 832.0 mg/g for AF, CV, and MG, respectively. The adsorption thermodynamic process of AF, CV, and MG shows a self-endothermic process. These results indicate that adsorption was affected by various parameters. The five cycles of adsorption-desorption indicate that the adsorbent can regenerate. The adsorption mechanism is the electrostatic attraction between the dye molecules and the adsorbent, hydrogen bonding, and pi-pi interaction.

Objective With the development of aerospace and national defense industries, the demand for high-performance aerospace components continues to grow. Nickel-based superalloys are widely used in the hot-end components of aerospace and gas turbine engines due to their excellent high-temperature strength, fatigue resistance, corrosion resistance, and oxidation resistance. Although this type of superalloy has many advantages, its high strength and low thermal conductivity increase the processing difficulty, especially for traditional machining methods. Therefore, it is of great significance to break through the limitations of conventional machining methods to improve the machining efficiency and quality of nickel-based superalloys. Methods The experiment is divided into three parts. First, a single-factor experiment was conducted, selecting five factors: the number of scans (N), laser power density (I), pulse repetition frequency (f), pulse overlap rate (rPO), and pump voltage (Vpump), to analyze changes in microgroove width, depth, and material removal rate (MMR), providing guidance for subsequent optimization of superalloy coaxial waterjet-assisted laser micro-machining. The experimental parameters for this section were listed in Table 2. The second part was a response surface experiment using a Box-Behnken design (BBD) to establish a regression equation for predicting MRR, investigating how different parameters interact and influence the results. The third part compared the geometric features, thermal damage, and processing quality of microgrooves processed by GAL and CWAL. For GAL processing, the water circuit was closed, and the air circuit was opened to introduce compressed air. Results and Discussions To investigate the effects of different laser treatments on the K4002 superalloy, EBSD (electron back scatter diffraction) analysis was conducted on the cross-sectional area of the microgrooves to characterize their crystallographic properties. Observations reveal that for microgrooves processed by GAL, the outermost recast layer exhibits significant orientation changes and a fine-grained structure, with a thickness of approximately ten micrometers. This may be attributed to rapid cooling. Due to the presence of cracks, the connection between the recast layer and the substrate is discontinuous. A region of approximately 5 mu m in width between the recast layer and the substrate exhibits minor orientation changes, which constitutes the heat-affected zone. This indicates that the surface layer of the nickel-based single-crystal superalloy undergoes a transformation from single-crystal to polycrystalline structure due to the thermal accumulation effect during GAL processing. The primary reason is that material removal in nanosecond laser processing of nickel-based alloys mainly occurs through two mechanisms: vaporization and melting. Within the laser pulse interval, molten material accumulates on the processed surface and recrystallizes. Under repeated laser exposure, the process of melting and recrystallization is repeated. The molten material is uniformly distributed on the processed surface, forming the recast layer. For microgrooves processed by CWAL, no significant orientation changes are observed, indicating that their microstructures are not affected by laser processing. In CWAL processing, the waterjet removes the ablated material from the processing area. Since the specific heat capacity of the solid material is lower than that of water, the heat generated during the process is absorbed and carried away by the waterjet. Since heat cannot accumulate continuously or be conducted to the substrate, the substrate material adjacent to the processing area is protected, thereby eliminating the heat-affected zone (HAZ) and reducing the formation of the recast layer. The microstructural characteristics of microgrooves processed by different lasers indicate that an appropriate cooling medium can effectively eliminate the thermal effects of laser processing and prevent thermal damage to the adjacent substrate. Conclusions GAL machining can produce microgrooves with an aspect ratio (AR) of 2.4-5.1. However, the AR does not change significantly with an increase in the number of scans. After 300 laser scans, the microgroove depth and width reached 241 mu m and 69 mu m, respectively. Additionally, severe slag accumulation was observed at the entrance of the microgrooves produced by GAL machining, with flake-like slag detected at the bottom of the microgrooves. Due to the presence of a large amount of oxygen in the auxiliary gas, a recast layer and HAZ were formed on the surface layer of the microgrooves during machining. CWAL processing formed relatively clear and deep microgrooves with a low AR of 0.8-2.4. Increasing the CWAL scans can increase the depth of the microgrooves. After 300 laser scans, the depth and width of the microgrooves reached 302 mu m and 128 mu m, respectively. The waterjet suppressed the formation of the HAZ, but formed a recast layer with a thickness of less than 1 mu m. Through single-factor experiments, it was found that when the pulse repetition frequency f is constant, the microgroove depth increases with increasing number of scans, while the MRR decreases. Conversely, when the number of scans is constant, the microgroove width and MRR are positively correlated with the f and negatively correlated with the microgroove depth. Laser power density I and pump voltage Vpump have a positive impact on microgroove depth and MRR. Additionally, increasing the pulse repetition frequency f leads to expanded thermal damage around the processing area and shallower processing depth. In the RSM experiments, the parameters influencing MRR, ranked from high to low, are Vpump, f, I and rPO. The optimized process parameters for maximizing MRR were identified as follows: I=1.67 GW/cm2, f=26.35 kHz, rPO=96.47 %, and Vpump=15.51 V (equivalent waterjet velocity vw=6.63 m/s).

Congo red dye wastewater is highly toxic and nondegradable, posing a significant threat to the environment. Hypercrosslinked porous materials (HCP) are effective candidates for the removal of dyes from wastewater. In this study, hypercrosslinked polystyrene (HCPS) with high specific area (1073.08 m2/g) was synthesized by using waste expanded polystyrene (EPS) as starting material. HCPS was then modified through a simple dopamine-assisted deposition of polyethyleneimine, resulting in the modified material HCPS@PDA/PEI, which retained a significant specific surface area of 738.36 m2/g and a porous structure with abundant functional groups. HCPS@PDA/PEI exhibits remarkable efficacy as a high-performance adsorbent for the removal of Congo red (CR) from aqueous solutions. The adsorption process of CR conforms to the pseudo-second-order kinetic model. Further fitting with the Langmuir isotherm model elucidates that the adsorption of CR occurs as a monolayer chemical adsorption, with a maximum adsorption capacity of 1030.31 mg/g, which is triple that of the unmodified HCPS (291.54 mg/g). The adsorption activation energy and thermodynamic parameters substantiate that the adsorption process is chemical in nature, spontaneous, and endothermic. Consequently, HCPS@PDA/PEI holds considerable promise for applications in the treatment of dye-contaminated wastewater.

In this study, an N, N-dimethyl-p-toluidine/benzoyl peroxide redox initiation system was used to synthesize a series of silicone-modified UV-curable acrylic pressure-sensitive adhesives (PSAs) via bulk polymerization. The oxidizing and reducing agents were added separately but simultaneously into a mixture of monomers. The impact of varying monomer content on the PSA's properties, as well as the influence of organosilicon incorporation on water and aging resistance, was evaluated through 180 degrees peel strength and initial adhesion tests. The results demonstrated that the PSA without organosilicon modification exhibited a maximum peel strength of 7.21 N/25 mm and an initial adhesion of 8.41 N/25 mm. Although the introduction of the organosilicon structure reduced both peel strength and initial adhesion, it notably improved the PSA's water resistance and aging resistance.Highlights Synthesis without solvent using redox initiator system. UV-cured system to enhance molecular weight and adhesion. Introduction of silane structure to improve water and aging resistance. Adhesion performance testing on different substrates (PET and BOPP).

Antibiotic resistance and biofilm formation pose as the primary challenges in the bacterial infectious diseases. Herein, a ferrocenyl cationic covalent organic polymer (COP) artificial peroxidase (POD) enzyme catalytic system (iTAFc-COP) was constructed based on the ternary Knoevenagel condensation of 2,4,6-trimethyl-triazine (TMT), ferrocene dicarboxaldehyde (Fc), and bromoethane (BE). The peroxidase-mimicking (POD-like) therapeutic activity of iTAFc-COP demonstrates dual stimuli-responsive activation, specifically triggered by both endogenous hydrogen peroxide (H2O2) and the pathologically weak acidic microenvironment (pH similar to 5.5). This unique responsive mechanism enables precise spatiotemporal control for targeted in situ antibacterial therapy, which is particularly effective against localized bacterial infections. The cationic framework of iTAFc-COP significantly enhances electrostatic interactions with negatively charged bacterial membranes, thereby promoting localized generation and efficient utilization of transient hydroxyl radicals (center dot OH) at the bacteria-material interface. Notably, iTAFc-COP exhibits remarkable photoresponsive behavior, demonstrating significantly enhanced photothermal conversion efficiency compared to its nonionic counterpart (TAFc-COP). This unique photothermal property enables light-mediated activation of enzymatic catalytic activity, establishing a photoenzyme synergistic system. TAFc-COP exhibits exceptional bacterial adhesion properties, enabling a self-amplifying therapeutic cascade through the synergistic interplay of cationic interactions, photothermal effects, and enzymatic activities. This trimodal antimicrobial strategy demonstrates superior efficacy in bacterial inactivation and biofilm disruption, effectively promoting wound healing progression in infectious conditions. The integrated multifunctionality establishes iTAFc-COP as an advanced therapeutic platform, offering a robust solution for combating infection-related pathologies through its unique combination of therapeutic modalities.

The increasing prevalence of electronic devices has led to a notable rise in the severity of electromagnetic interference (EMI). Nanofillers in conventional EMI shielding materials aggregate in the matrix, affecting their usability. Hence, with the aim of optimizing the dispersion of silver nanowires (AgNWs) within the matrix and augmenting its conductivity, we herein report a method for modifying silver nanowires and conduct an exhaustive investigation into its practical implementation and performance. An ultra-long aspect ratio AgNWs with an average length of 150.23 mu m, an average diameter of 129.82 nm, and an aspect ratio of about 1157 was prepared. Surface hydroxylated silver nanowires (M-AgNWs) were obtained by bis(2-hydroxyethyl) disulfide modification. Polyvinyl alcohol (PVA) and borax hydrogel systems were prepared by the addition of M-AgNWs, resulting in the formation of PVA/Borax/M-AgNWs hydrogels (PB/M-AgNWs). The tensile strength of the self- healing PB/M-AgNWs (0.1 %) hydrogel was able to reach 78 % of the original value. The PB/M-AgNWs (0.2 %) hydrogel, with a conductivity of 3.59 S/m, exhibited a conductivity of 3.09 S/m following self- healing at room temperature, with an estimated self-healing efficiency of 86 %. The hydrogel EMI shielding effectiveness of 2 mm PB/M-AgNWs (0.1 %) is 32.03 dB. 8 mm PB/M-AgNWs (0.1 %) hydrogel has an EMI shielding effectiveness of 65.10 dB, which is 99.9999 % attenuation of the incident electromagnetic waves (EMW).

Background: Diabetes can cause an increase in intracellular glucose, leading to neuronal damage and microvascular dysfunction. Neuroprotective agents 1α,25-dihydroxyvitamin D3 (1,25-D3) can reduce neurological complications. The main purpose of this study is to evaluate the levels of inflammatory factors and vascular protective factors in streptozotocin (STZ)-induced diabetic rats and determine whether 1,25-D3 can protect the rat brains from hyperglycemia through the glucagon-like peptide-1 (GLP-1)R/PI3K/AKT signal pathway. Methods: We first evaluated whether the relevant target could effectively bind to 1,25-D3 through molecular docking. Next, we established STZ-induced diabetic rat models for in vivo experiments to verify the targets in molecular docking that have good binding effects on 1,25-D3. After 8 weeks of a high-fat diet (HFD) and an intraperitoneal injection of STZ (35 mg/kg body weight), the experimental type 2 diabetic rat model was created, and the morphological changes of the cerebral cortex were measured by performing hematoxylin and eosin (H&E) staining. Western blotting (WB) was used to detect the proteins' expression of relevant targets, and the RT-qPCR was used to analyze the mRNA levels of relevant targets in the cerebral cortex. We also utilized the enzyme-linked immunosorbent assay (ELISA) kit for detecting the protein content of relevant targets. Results: Molecular docking showed that 1,25-D3 had good binding ability with related targets, such as GLP-1R, PI3K, AKT1, vascular endothelial growth factor-α (VEGF-α), endothelial nitric oxide (NO) synthase (e-NOS), intercellular adhesion molecule-1 (ICAM-1), and vascular intercellular adhesion molecule-1 (VCAM-1). Experimental verification results found that 1,25-D3 partially prevented abnormalities in brain function and structure caused by diabetes. Meanwhile, the ICAM-1 and VCAM-1 levels were increased in the high-glucose group, e-NOS levels were decreased, and the relative expression of GLP-1R, VEGF-α, p-PI3K/PI3K, and p-AKT/AKT was reduced. 1,25-D3 abolished these changes, and these effects were suppressed by specific inhibitors. Conclusions: 1,25-D3 alleviates neuroinflammation and improves vascular endothelial dysfunction through multitarget and multipathway by upregulating the GLP-1R/PI3K/AKT signaling axis to improve diabetes-induced brain injury.

Background Kasai portoenterostomy (KPE) remains the primary intervention for biliary atresia (BA), but its outcomes are highly variable. Reliable prognostic biomarkers remain elusive, complicating the management and prediction of postoperative progression. Method Liver biopsies from BA patients taken at and after KPE (post-KPE) were used to generate organoids for RNA-sequencing analysis. Control organoids were derived from non-BA livers. Differential gene expression and enrichment analyses were performed to assess post-KPE transcriptomic changes between native liver survivors (NLS) and patients who eventually became liver transplant recipients (LTR). Results Organoid datasets: 70 from liver biopsies at KPE (10 patients), 112 from post-KPE livers (13 livers; 12 patients), and 47 from control livers (9 patients). At KPE, BA organoids displayed mainly hepatocyte expression, a trait notably reduced in control organoids. Similarly, post-KPE organoids from NLS revealed a significant decrease in hepatocyte expression features and an overall increase in cholangiocyte expression features. A similar hepatocyte-to-cholangiocyte expression transition was evidenced in paired liver organoids (at- and post-KPE) generated from an NLS. In contrast, post-KPE organoids from LTR maintained a high level of hepatocyte expression features. Conclusion Our study demonstrated that an elevated expression of hepatocyte features in KPE organoids may indicate aberrant cholangiocyte development in BA livers. In contrast, a post-KPE hepatocyte-to-cholangiocyte expression transition in NLS may imply effective biliary recovery. The lack of this transition in LTR organoids indicates ongoing disease progression, highlighting the potential for organoid-based transcriptomic profiling to inform KPE success and guide BA management. Level of Evidence Level III

Noise has become a major potential problem in modern society, with a profound impact on human health. There is an urgent need to develop more effective sound-absorbing materials to control noise. In this study, composite foams were prepared by the sacrificial template method combined with non-solvent-induced phase separation using polyvinylidene fluoride (PVDF) as matrix and diatomaceous earth (DE) as filler. The result shows the addition of DE can act as a crystallization site to induce the formation of β phase in the PVDF matrix, thus enhancing the piezoelectricity of the foam. Due to the local piezoelectric effect of PVDF promoted by DE and the high porosity of DE itself, the sound absorption performance of DE/PVDF composite foam was better than that of pure PVDF foam. When the DE was 5 wt

Objectives Explore the Clinical Value of Visual endoscopic retrograde appendicitis therapy in Pediatric Appendicitis. Methods Analysis of clinical data from 38 pediatric patients who underwent Visual endoscopic retrograde appendicitis therapy (V-ERAT) for appendicitis at Shenzhen Children's Hospital's Hepatobiliary and Oncology Surgery Department between December 2023 and April 2025. The study evaluated V-ERAT success rates, operative times, first-hospitalization appendectomy rate, and recurrence rate to evaluate the safety and efficacy of this procedure. Results All 38 patients underwent V-ERAT, with a surgical success rate of 92.11%. Three pediatric patients underwent laparoscopic appendectomy during their initial hospitalization, yielding an appendectomy rate of 7.89% during the first admission. The median operative time was 75 (55, 101) minutes. Thirty-three cases (94.29%) achieved a Numerical Rating Scale score < 3 at 6 hours postoperatively. No V-ERAT related complications occurred. Among the 34 patients followed up, 6 experienced recurrence, yielding a recurrence rate of 17.14%. Conclusions V-ERAT for pediatric appendicitis is a novel minimally invasive technique integrating diagnosis and treatment while preserving the appendix. It demonstrates promising preliminary efficacy and operates with high safety and reliability without requiring X-ray or ultrasound guidance. This approach features no external surgical incisions and facilitates rapid postoperative recovery, aligning with the principles of enhanced recovery after surgery (ERAS).

Conventional antimicrobial sutures often fail to respond dynamically to the evolving demands of wound healing, potentially presenting risks associated with cytotoxicity. In this study, we synthesized copper-luteolin metal-phenolic network particles (Cu-Lut MPNs) through a one-pot reaction. Subsequently, we coated them onto polydopamine-modified poly (lactic-co-glycolic acid) (PGLA) sutures, resulting in the development of a pH-responsive surgical suture, designated as Cu-Lut@P/PGLA. In acidic inflammatory environments, the pH-responsive decomposition of Cu-Lut@P/PGLA facilitates the release of Cu2+ (1.89 mgmL(-1)) and Lut (229 mu gmL(-1)), which collectively drive significant antibacterial activity, achieving a 99 % inhibition rate against both Escherichia coli and Staphylococcus aureus, along with promising antioxidant efficacy (DPPH and ABTS are 81.7 % and 86.3 % respectively). Notably, due to the gentle preparation process, the original mechanical property and handling performance of the Cu-Lut@P/PGLA suture were preserved. Additionally, in vitro and in vivo studies indicate that Cu-Lut@P/PGLA suture has excellent biocompatibility (hemolysis rate < 3 % and fibroblast viability greater than 90 %). In a mice wound model infected with Staphylococcus aureus, the Cu-Lut@P/PGLA suture demonstrates excellent antibacterial activity compared to the control group. It significantly suppresses the inflammatory response and promotes enhanced collagen regeneration. This study may shed light on the development of smart sutures that combine dynamic antimicrobial regulation and tissue regeneration functions.

The rapid development of DNA nanotechnology has made it possible to explore information security methods based on non-computational complexity, providing an effective way to avoid the threats that high-performance computational methods pose to modern cryptography. However, most molecular information security methods require both external stimuli and specific DNA signals, placing high demands for experimental conditions and DNA-sequence design, limiting their practical application and further development. Herein, we proposed an EHairpin-driven double-stem-loop programmable allosteric strategy for molecular security access control. Specifically, this strategy regulates the conformational changes in the double-stem-loop programmatically by responding to specific DNA input signals, converting molecular conformational changes into signal-response triggering events. We constructed a programmable allosteric strategy through the EHairpin structure to achieve the temporal response of the DNA signal-driven molecular structure and further built a molecular-switch-response circuit for multiple input signals. Finally, we implemented an EHairpin-driven molecular security access control system, which has a three-level security assurance mechanism of administrator authentication, authorization, and user authentication. This strategy offers a powerful method for security access control of molecular devices, further promoting the development of next-generation information security and providing some new ideas for the secure control of nanomachines, which has great potential in biosensing and disease diagnosis.

Organosilicon materials are rich in Si-O bonds, which possess relatively longer bond lengths but high bond energies, making them excellent high-temperature-resistant materials. In polysiloxanes, each silicon atom is bonded to two oxygen atoms, resulting in a typical thermal decomposition temperature of around 200 degrees C. In contrast, in polysilsesquioxanes, each silicon atom is bonded to three oxygen atoms, endowing them with superior thermal stability compared to polysiloxanes. Their decomposition temperatures generally exceed 300 degrees C, making them outstanding candidates for high-temperature-resistant and flame-retardant materials. In this study, a ladder-like polysilsesquioxane (LLP) was synthesized, and a composite resin with enhanced flame retardancy, smoke suppression, and thermal stability was developed by incorporating surface-modified nano-Al(OH)s. The LLP was obtained via co-condensation of phenyl, epoxycyclohexyl, and glycidoxypropyl silane coupling agents in dichloromethane. A dual-curing strategy involving titanium(IV) isopropoxide, dibutylamine, and 4,4 '-diaminodiphenylmethane was employed to crosslink the LLP chains, resulting in a denser and more robust network. LLP exhibited a tensile strength of 30.98 MPa, which is more than 20 times higher than that of PDMS (1.54 MPa). Subsequently, nano-Al(OH)s modified with bis(2-ethylhexyl pyrophosphate) titanate (AlPT) was blended with LLP to yield a high-performance composite resin, referred to as AlPT-T-LLP. Compared with commercial polydimethylsiloxane (PDMS), AlPT-T-LLP exhibited a 37.34 % reduction in total heat release (THR) and a 76.03 % decrease in total smoke production (TSP) during combustion. Furthermore, the thermal degradation temperature was significantly elevated from 296 degrees C for PDMS to 402 degrees C for AlPT-T-LLP. These findings offer a promising strategy for the design of advanced polysiloxane-based resins with superior flame retardancy and thermal resistance for high-performance applications.

With the continuous advancement and rapid iteration of electronic devices, the impact of electromagnetic interference (EMI) on industrial production and daily life has become increasingly profound. Hydrogel-based materials have emerged as promising candidates for EMI shielding. However, monolithic-property hydrogels often fail to meet the multifunctional requirements in practical applications. Therefore, a multifunctional hydrogel material composed of deep eutectic solvent (DES), modified silver nanowires (M-AgNWs), and polyvinyl alcohol (PVA) is reported. Among these, DES possesses abundant hydrogen bonds and excellent electrical conductivity compared to ionic liquids, effectively enhancing the electrical conductivity and mechanical properties of hydrogels. The synthesized AgNWs (L/D ratio 1194) were modified with bis(2-hydroxyethyl) disulfide to introduce hydroxyl groups on their surfaces, thereby improving their dispersion in PVA. Following crosslinking with borax, the borate ester bonds and hydrogen bonds formed within the composite material confer self-healing properties. The addition of 0.1 wt% M - AgNWs exhibited a hydrogel tensile strength of 0.48 MPa and an elongation at break of 344 %, which could be up to 75 % of the original after self-healing at room temperature. The hydrogel exhibits a conductivity of up to 3.937 S/m, an EMI shielding effectiveness (SE) of 80.59 dB, and achieves 99.999999 % attenuation of incident electromagnetic waves (EMW). Moreover, the prepared hydrogels also demonstrate the potential to function as wearable, flexible body sensors. This work provides valuable insights for the preparation of flexible, high-strength multifunctional hydrogels.