Objective To explore the effect of statins and low protein diet on early diabetic nephropathy,especially on inflammato-ry factors.Methods 74 cases of early diabetic nephropathy patients in our hospital were divided into two groups.The control group was only treated with low protein diet,and the observation group was treated with statins and low protein diet.UAER and serum TNF -α, hs -CRP,SCr of two groups were observated.Results The level of UAER and serum TNF -α,hs -CRP of two groups were signifi-cantly higher than normal (P >0.05).UAER levels of the control group significantly decreased after treatment (P <0.05),but TNF alpha and hs -CRP levels had no statistical difference after treatment (P <0.05).UAER and serum TNF -α,hs -CRP levels signif-icantly decreased after treatment in observation group (P <0.05),the level of SCr had no obvious difference (P >0.05).Conclu-sion s Early diabetic nephropathy treated by statins and low protein diet can effectively reduce the inflammatory factor levels and allevi-ate the proteinuria.

目的 观察尿毒症患者血清晚期氧化蛋白产物水平,对比不同血液净化方式对其清除效果,探讨其与心血管疾病的关系。方法 将60例维持性血液透析患者随机分为单纯血液透析(HD)组、血液透析联合血液透析滤过(HD+HDF)组和血液透析联合血液灌流(HD+HP)组,每组20例;另设健康对照及尿毒症未透析组,观察12个月。结果 尿毒症未透析组血清晚期氧化蛋白产物明显高于健康对照组(P<0.01),透析后进一步升高(P<0.05);12个月后,HD+HDF组及HD+HP组血清晚期氧化蛋白产物水平及心血管并发症发生率低于HD组(P<0.05)。结论 ①尿毒症患者HD后血清晚期氧化蛋白产物水平升高;②HD+HDF或HD+HP血液灌流能降低尿毒症患者血清晚期氧化蛋白产物水平,改善维持性血液透析患者心血管预后。

本文分析我中心152例维持性血液透析(maintenance hemodialysis,MHD)患者的资料,了解MHD患者的性别、年龄、原发病、血管通路、治疗转归和传染性疾病感染率等流行病学情况,为制定慢性肾脏病(chronic kidney disease,CKD)的防治方案提供依据.