We report a new epidemic outbreak of hemorrhagic fever with renal syndrome occurred in Ardennes during winter period (1992–1993).

118 cases of erysipela admitted to Charleville-Mezieres hospital in internal medecine department between January 1989 and December 1991 were analysed retrospectively. General facilitating factors were noted in 44 % of the patients and local in 64,5 %. The first line treatment was in 84 % of the cases penicillin G (12 MUnites per day) effective in 75,8 % of the cases. Another treatment used was ceftriaxone and pristinamycine in first stage or when patients were allergic to penicillin G. Local complication appeared in 6 % of the cases and recurrence in 7 %. When recurrences were multiple, we proposed preventive therapy with benzyl penicillin in intramuscular (2,4 MUnits twice a month) during three or six month.

During 1990, 166 patients were treated by quinolones. 8,4 % adverse reactions were noted in 6,6% of treated patients. The most frequent adverse effects were arthromyalgias and CNS reactions (1,7 %). The therapy had to be discontinued in 2,4 % of cases. These side-effects were always reversible after drug with drawal.

From January through December 1992, 143 patients were given fluoroquinolone therapy. A total of 32 adverse events were recorded in 12.6 % of patients. Gastrointestinal symptoms and joint or muscle pain were the most common adverse effects (7 %), neurosensory and skin manifestations occurred in 6.3 % and 2.1 % of patients, respectively. Discontinuation of treatment was required in 2.8 % of cases. All adverse events resolved following treatment withdrawal.

We reported twenty one cases of leptospirosis occurred in Ardennes between 1987 and 1992.

We reported the center's experience of Charleville-Mezières between 1988 to 1991. We have seen 2112 travellers during these four years. Chloroquine and Proguanil is the usually prophylaxis used for malaria and is well tolerated, one failure is reported.

We reported 118 cases of eresypela admitted to Charleville-Mézières hospital, analysed retrospectively. General falicitating factors were noted in 44 %, local in 64,5 %. Penicillin G intravenous 12 M/units per day was effective in 64 %, another treatment was used based on Ceftriaxone or Pristinamycine in second stage in 14 % or in first stage in 22 %. Some complication appeared in 22 cases.

We are reporting 9 cases of haemorragic fever with renal syndrome (HFRS) hospitalised from May to August 1990. These patients presented episodes of high temperature, headache, backpain or abdominal pain with fleeting biological modifications confirmed by repeated blood tests (creatinine, platelets counts).