Introduction: Delayed enhancement - magnetic resonance imaging (DE-MRI) has demonstrated that nonischemic cardiomyopathy is mainly characterized by intramural or epicardial fibrosis whereas global endomyocardial fibrosis suggests cardiac involvement in autoimmune rheumatic diseases or amyloidosis. Conduction disorders and sudden cardiac death are important manifestations of autoimmune rheumatic diseases with cardiac involvement but the substrates of ventricular arrhythmias in autoimmune rheumatic diseases have not been fully elucidated. Methods and Results: 20 patients with autoimmune rheumatic diseases presenting with ventricular tachycardia (VT) (n=11) or frequent ventricular extrasystoles (n=9) underwent DE-MRI and / or endocardial electroanatomical mapping of the left ventricle (LV). 10 patients with autoimmune rheumatic diseases underwent VT ablation. Global endomyocardial fibrosis without myocardial thickening and unrelated to coronary territories was detected by DE-MRI or electroanatomical voltage mapping in 9 of 20 patients with autoimmune rheumatic diseases. In the other patients with autoimmune rheumatic diseases, limited regions of predominantly epicardial (n = 4) and intramyocardial (n = 5) fibrosis or only minimal fibrosis (n = 2) were found using DE-MRI. Endocardial low-amplitude diastolic potentials and pre-systolic Purkinje or fascicular potentials, mostly within fibrotic areas, were identified as the targets of successful VT ablation in 7 of 10 patients with autoimmune rheumatic diseases. Conclusion: Global endomyocardial fibrosis can be a tool to diagnose severe cardiac involvement in autoimmune rheumatic diseases and may serve as the substrate of ventricular arrhythmias in a substantial part of patients.

Introduction: In patients with left ventricular (LV) nonischemic cardiomyopathy and monomorphic ventricular tachycardia (VT), midmyocardial and epicardial substrates are often involved but endocardial structures may also be affected. Delayed enhancement – magnetic resonance imaging (DE–MRI) was used to characterize the substrates of predominantly epicardial VT to improve identification of target sites for ablation. Methods and Results: 12 patients with LV nonischemic cardiomyopathy and monomorphic VT (prior myocarditis in 9) had a predominantly epicardial (n = 8) or epicardial-only DE-MRI substrate (n = 4). Modest-sized endocardial involvement in predominantly epicardial substrates was identified by DE-MRI in 8 patients. Mapping of 22 VTs was performed in 12 patients using an endo-epicardial approach in 6 patients and an endocardial-only approach in 6 patients. Endocardial VT reentry circuit exit sites as defined by entrainment and pace mapping criteria corresponded to endocardial breakthroughs from predominantly epicardial DE-MRI substrates in 7 patients. The endocardial VT exits were located at the ventricular base near the mitral annulus in 6 patients. Successful endocardial ablation of at least one VT was accomplished in 5 patients. Epicardial ablation as a part of an endo-epicardial approach or as epicardial-only ablation was performed in 6 patients and was successful in 4 patients. Conclusion: Endocardial breakthroughs from predominantly epicardial DE-MRI substrates are often located near the ventricular base in the perivalvular region and correlate with endocardial VT reentry circuit exit sites amenable to ablation.

Objective Atrial fibrillation or atrial flutter (AF) and heart failure (HF) often go hand in hand and, in combination, lead to an increased risk of death compared with patients with just one of both entities. Sex-specific differences in patients with AF and HF are under-reported. Therefore, the aim of this study was to investigate sex-specific catheter ablation (CA) use and acute in-hospital outcomes in patients with AF and concomitant HF in a retrospective cohort study. Methods Using International Statistical Classification of Diseases and Related Health Problems and Operations and Procedures codes, administrative data of 75 hospitals from 2010 to 2018 were analysed to identify cases with AF and HF. Sex differences were compared for baseline characteristics, right and left atrial CA use, procedure-related adverse outcomes and in-hospital mortality. Results Of 54 645 analysed cases with AF and HF, 46.2% were women. Women were significantly older (75.4±9.5 vs 68.7±11.1 years, p<0.001), had different comorbidities (more frequently: cerebrovascular disease (2.4% vs 1.8%, p<0.001), dementia (5.3% vs 2.2%, p<0.001), rheumatic disease (2.1% vs 0.8%, p<0.001), diabetes with chronic complications (9.7% vs 9.1%, p=0.033), hemiplegia or paraplegia (1.7% vs 1.2%, p<0.001) and chronic kidney disease (43.7% vs 33.5%, p<0.001); less frequently: myocardial infarction (5.4% vs 10.5%, p<0.001), peripheral vascular disease (6.9% vs 11.3%, p<0.001), mild liver disease (2.0% vs 2.3%, p=0.003) or any malignancy (1.0% vs 1.3%, p<0.001), underwent less often CA (12.0% vs 20.7%, p<0.001), had longer hospitalisations (6.6±5.8 vs 5.2±5.2 days, p<0.001) and higher in-hospital mortality (1.6% vs 0.9%, p<0.001). However, in the multivariable generalised linear mixed model for in-hospital mortality, sex did not remain an independent predictor (OR 0.96, 95% CI 0.82 to 1.12, p=0.579) when adjusted for age and comorbidities. Vascular access complications requiring interventions (4.8% vs 4.2%, p=0.001) and cardiac tamponade (0.3% vs 0.1%, p<0.001) occurred more frequently in women, whereas stroke (0.6% vs 0.5%, p=0.179) and death (0.3% vs 0.1%, p=0.101) showed no sex difference in patients undergoing CA. Conclusions There are sex differences in patients with AF and HF with respect to demographics, resource utilisation and in-hospital outcomes. This needs to be considered when treating women with AF and HF, especially for a sufficient patient informed decision making in clinical practice.

INTRODUCTION:Concealed structural abnormalities were detected by delayed enhancement - magnetic resonance imaging (DE-MRI) in patients with apparently idiopathic tachycardia of left ventricular (LV) origin. Basal septal fibrosis was evaluated as a potential arrhythmia substrate in patients with left ventricular outflow tract (LVOT) arrhythmias.METHODS AND RESULTS:A total of 22 patients with LVOT arrhythmias, including frequent monomorphic premature ventricular complexes (PVCs) in 15 patients and ventricular tachycardia (VT) in 7 patients, underwent catheter ablation and DE-MRI. A total of 19 patients with frequent PVCs and 17 patients with idiopathic VT of other origin served as a control group. Basal septal intramural fibrosis as thin strip-shaped intramyocardial DE or as marked intramyocardial DE involving >25% of wall thickness was detected more frequently in patients with LVOT arrhythmias (41% and 32%) than in patients with non LVOT arrhythmias (14% and 3%). After successful ablation, 4/16 patients with basal septal intramural fibrosis and LVOT PVCs (n = 3) or LVOT VT (n = 1) compared with no patient without basal septal fibrosis experienced episodes of sustained VT with similar or different QRS morphology resulting in ICD therapy in three patients. Follow-up DE-MRI after PVC ablation (17 ± 7 months) revealed an increase in LV ejection fraction from 49 ± 5% to 56 ± 5% (n = 9) but the amount of septal DE remained unchanged.CONCLUSIONS:Basal septal intramural fibrosis may serve as the arrhythmia substrate in a substantial part of patients with premature ventricular complexes (PVCs) and VT originating from the LVOT and identifies patients with continued risk for VT recurrence after initially successful ablation of LVOT arrhythmias.

Zusammenfassung„Das sollte ich eigentlich wissen!“ So oder ähnlich äußern sich manche Ärzte in der Praxis oder im Notdienst, denen ein 12-Kanal-EKG eines hämodynamisch beeinträchtigten Patienten vorgelegt wird, das eine Tachykardie mit breiten Kammerkomplexen zeigt. Trotz einer Fülle an etablierten Kriterien kann die korrekte Diagnose einer Tachykardie mit breiten Kammerkomplexen durchaus schwierig oder alleine aufgrund des 12-Kanal-EKG sogar unmöglich sein. In diesem Beitrag erhalten Sie nützliche Tipps.

ECG criteria for identifying an epicardial origin of ventricular tachycardia (VT) have mainly been described for VTs with basal-superior and lateral origin.

BackgroundIntraoperative controlled mechanical ventilation (CMV) changes the intrathoracic geometry and may impact postoperative left ventricular (LV) lead function after CRT implantation. This multicenter study investigates the effect of intraoperative ventilation setting (spontaneous breathing[SB] vs CMV) on postoperative LV lead function taking into account patients' body mass index (BMI). MethodsCRT implantation was performed at two centers during SB in 92 and during CMV in 73 patients. Follow-up was carried out after 3 5 and 36 53 days. Functional lead parameters (FLP; pacing threshold and impedance), postoperative adverse events (A; phrenic nerve stimulation [PNS] and lead malfunction), and patients' BMI were assessed. Delta values of FLP between baseline and follow-up visits were analyzed applying an analysis of covariance model to detect subclinical alterations in LV lead function. ResultsAE occurred in a total of 36 (21%) patients. PNS was observed in 26 (15%) patients and LV lead repositioning due to malfunction was necessary in 10 (6%) patients. Both AE and FLP delta values between baseline and follow-up were not associated with intraoperative ventilation settings nor the patients' BMI. ConclusionsThis study demonstrates that there is no impact of the intraoperative ventilation setting (SB vs CMV) on postoperative FLP or the occurrence of AE. This is also the case taking into account the BMI. With respect to these findings both approachessedation only or general anaesthesia including CMVcan be safely implemented during CRT implantation.

Aims Catheter ablation is an established therapy in patients with symptomatic atrial fibrillation (AF) with increasing popularity. Pericardial effusion requiring intervention (PE) is one of the most threatening adverse outcomes. The aim of this study was to examine rates of PE after catheter ablation in a large 'real-world' data set in a German-wide hospital network. Methods and results Using ICD and OPS codes, administrative data of 85 Helios hospitals from 2010 to 2017 was used to identify AF catheter ablation cases [Helios atrial fibrillation ablation registry (SAFER)]. PE occurred in 0.9% of 21 141 catheter ablation procedures. Patients with PE were significantly older, to a higher percentage female, had more frequently hypertension, mild liver disease, diabetes with chronic complications, and renal disease. Low hospital volume (<50 procedures per year) and radiofrequency ablation (vs. cryoablation) were significantly associated with PE. Using two logistic regression models, age, female gender, hypertension, mild liver disease, diabetes with chronic complications, renal disease, low hospital volume, and radiofrequency ablation remained independent predictors for PE. Conclusion Overall PE rate was 0.9%. Predictors for PE occurrence involved factors ascribed to the patient (age, gender, comorbidities), the type of catheter ablation (radiofrequency), and the institution (low-volume centres).

Aims Atrial fibrillation (AFib) and atrial flutter (AFlut) are common arrhythmias with increased use of invasive procedures. A steady re-evaluation of relevant safety endpoints is recommended and both quality management and pay-for-performance programs are evolving. Therefore, the aims of this study were (i) to investigate and report overall in-hospital mortality and mortality of invasive arrhythmia-related procedures and (ii) to identify mortality predictors in a German-wide hospital network. Methods and results Administrative data provided by 78 Helios hospitals between 2010 and 2017 were examined using International Statistical Classification of Diseases and Related Health Problems- and Operations and Procedures-codes to identify patients with AFib or AFlut as main discharge diagnosis or secondary diagnosis combined with invasive arrhythmia-related interventions. In 161 502 patients, in-hospital mortality was 0.6% with a significant decrease from 0.75% to 0.5% (P < 0.01) during the observational period. In multivariable analysis, age [odds ratio (OR) 2.69, 95% confidence interval (CI) 2.36-3.05; P < 0.01], high centre volume (OR 0.57, 95% CI 0.50-0.65; P < 0.01), emergency hospital admission (OR 1.57, 95% CI 1.38-1.79; P < 0.01), and Charlson Comorbidity Index (CCI, OR 4.95, 95% CI 4.50-5.44; P < 0.01) were found as independent predictors of in-hospital mortality. Mortality rates were 0.05% for left atrial catheter ablation (CA, n = 21 744), 0.3% for right atrial CA (n = 9972), and 0.56% for implantation of a left atrial appendage occluder (n = 2309), respectively. Conclusion We analysed for the first time in-hospital mortality rates of patients with atrial arrhythmias in a German-wide, multi-centre administrative dataset. This allows feasible, comparable, and up-to-date performance measurement of clinically important endpoints in a real-world setting which may contribute to quality management programs and towards value-based healthcare.

Patients with frequent premature ventricular contractions (PVCs) are often highly symptomatic with significantly reduced quality-of-life. We evaluated the outcome and success of PVC ablation in patients in the German Ablation Registry.

Ventricular arrhythmias (VAs) from the left ventricular outflow tract (LVOT) can have multiple exits exhibiting divergent ECG features.

BackgroundTypical left bundle branch block (LBBB) during ventricular tachycardia (VT) is a diagnostic criterion of bundle branch reentry tachycardia (BBRT) with activation of the right bundle in the anterograde direction.Methods and ResultsEleven patients (seven male, 60 ± 12 years) with nonischemic cardiomyopathy (left ventricular ejection fraction 37 ± 16%) presenting with BBRT were successfully treated by ablation of the right bundle. Among them, five patients had atypical surface electrocardiograms (ECGs) differing from a typical LBBB during the VT. Three patients with severe enlargement and dysfunction of the left ventricle had broadened irregular QRS complexes with rR or RS configuration in lead V6 during the BBRT. Two patients with enlargement and/or hypokinesia of the right ventricle had entirely or almost entirely negative complexes (QS) in the chest leads (V1–V6) during the VT. Activation mapping in these two patients revealed that the exit site of the BBRT was in the anterior right ventricle generating a negative concordance in the precordial leads.ConclusionsAtypical surface ECGs with broadened irregular QRS complexes or negative concordance in the precordial leads can complicate the correct diagnosis of BBRT in patients with severe left ventricular dysfunction and involvement of the right ventricle.

Ein Makroreentry innerhalb des His-Purkinje-Systems kann zu einer anhaltenden ventrikulären Tachykardie (VT) führen, die als Bundle-Branch-Reentry-VT bezeichnet wird. Die Bundle-Branch-Reentry-VT ist i. d. R. mit einer Erkrankung des His-Purkinje-Systems und einer eingeschränkten linksventrikulären Funktion assoziiert. Im Fall der typischen Bundle-Branch-Reentry-VT wird der rechte Schenkel in anterograder Richtung aktiviert, und die ventrikuläre Depolarisation beginnt am Ende des rechten Schenkels im ventrikulären Septum mit der Folge einer typischen Linksschenkelblock QRS-Morphologie. Bei Patienten mit schwerer linksventrikulärer Dysfunktion und Beteiligung des rechten Ventrikels werden aber auch atypische Oberflächen-EKG-Befunde beobachtet, welche die Diagnose einer Bundle-Branch-Reentry-VT erschweren können. Die Diagnose einer Bundle-Branch-Reentry-VT ist von großer Bedeutung, da bei Patienten mit Bundle-Branch-Reentry-VT häufig serielle Schockabgaben eines implantierbaren Kardioverter-Defibrillators (ICD) auftreten können, die auf Rezidiven durch sofortige Reinitiierung der VT beruhen. Die Ablation des rechten Schenkels führt zu einer sicheren Therapie der Bundle-Branch-Reentry-VT und kann häufige ICD-Interventionen verhindern. Nach Ablation der Bundle-Branch-Reentry-VT bleibt aufgrund der häufig schweren linksventrikulären Dysfunktion eine hohe Mortalität bestehen, und die Patienten sollten einer kardialen Resynchronisationstherapie (CRT-D) zugeführt werden.

Sustained ventricular tachycardia (VT) in patients with nonischemic cardiomyopathy (NICM) often involves midmyocardial and epicardial structures. Delayed-enhancement magnetic resonance imaging (DE-MRI) of scar and fibrosis is the method of choice to define the substrate of monomorphic VT.

A 36-year-old patient was admitted after successful resuscitation due to ventricular fibrillation. The patient recovered without neurological sequelae. Cardiological examination including QTc interval, ajmaline testing, echocardiography, coronary angiography, and cardiac magnetic resonance imaging revealed no abnormal findings. The patient received a dual-chamber ICD …

Nonreentrant ventricular tachycardia (VT) originates in hearts without structural disease but occasionally can occur in patients with different cardiomyopathies equipped with an implantable cardioverter defibrillator (ICD).