Abstract: The fulminant form of post‐transplant lymphoproliferative disorder (PTLD) is very uncommon and occurs in approximately 1% of PTLD patients. Approximately 85% of these lesions are of B‐cell origin, and most of them are associated with Epstein–Barr virus infection. Fulminant PTLD is frequently associated with a systemic inflammatory response syndrome, and may be difficult to differentiate from septicemia. We describe the case of a 59‐yr‐old man who suffered from prolonged septicemia in the immediate post‐transplant period, and presented again four months after cardiac transplantation with fever, painful liver edge and gastrointestinal bleeding. The diagnosis of fulminant PTLD with advanced multiorgan infiltration by a diffuse large‐cell lymphoma of B‐cell phenotype was made. During treatment with rituximab, the patient died from Enterococcus faecium septicemia. The sequence of septicemia, PTLD and, finally again, septicemia is an unusual challenge and urges for an aggressive diagnostic approach, where markers like procalcitonin may aid in the discrimination of fulminant PTLD from septicemia.
Scientific and Clinical Abstracts From the 37th Annual Wound, Ostomy and Continence Conference: Las Vegas, Nevada June 12–16, 2005: Research Abstracts: Wound—Dermatological Management/Issues
Invasive meningococcal disease (IMD) is an important cause of morbidity and mortality in children and adults. This study was conducted to determine a possible increase in IMD in recent years with special interest focused on serogroup C disease. From January 1st 1993 to December 31st 2002, IMD was studied in one million residents of Austria. We used active, population-based surveillance data from the Office of Public Health. A total of 126 patients with positive blood and/or cerebrospinal fluid culture or positive swabs for Neisseria meningitidis were studied. The median age of all patients was 9.5 years (range 1 month to 63 years). The average incidence of all IMD subgroups was 1.05 cases per 100,000 person years and was highest in children 0–4 years old (7.08 cases per 100,000 person years) followed by young adults aged 15 to 19 years (4.35 cases per 100,000 person years). Serogroup C IMD occurred in 1.30 cases/100,000 person years in patients aged 0 to 4 years and in 1.92 cases/100,000 person years in patients aged 15 to 19 years. Overall mortality was 11.1%. There was a significant increase ( P =0.001) in IMD due to serogroup B disease within the last 10 years. In contrast, serogroup C disease did not increase during the last decade. Conclusion: Currently, we do not recommend mass vaccination against serogroup C disease in Austria, but young adults aged 15 to 19 years display a high incidence of meningococcal C disease. In this age group, vaccination against serogroup C disease should be considered.
AbstractThe thiazyl compound (I) is irradiated to give the trimeric derivative (II).
A Simple Method for the Preparation of Cationic Organometallic Sulfur Dioxide Complexes by Metal-Metal Bond Cleavage [Co(CO)4SO2]+ AsF (9) is isolated from the reaction of Co2(CO)8 (8) with AsF5 in liquid SO2. Similarly the known complexes [M(CO)5SO2]+ AsF6− [M = Mn, Re (6a, 6b)] or [η5-CpFe(CO)2-SO2]+ AsF (7) can be prepared by metal-metal bond cleavage from M2(CO)10 and [η5-CpFe-(CO)2]2, respectively.
AbstractThe reaction of Co2(CO)8 (Ia) with AsFs in liq.
The decomposition and trimerisation of (CF3)2 NOSN (2) are investigated, the structure determinations of 2 (by electron diffraction in the gas phase) and of [(CF3)2 NOSN]3 (6) (by x-ray crystallography) are reported.
Eine Fülle neuer Thionitrosyl-Komplexe sollte auf einem recht allgemein anwendbaren Weg erhältlich sein: der Umsetzung von kationischen CO-oder SO2-Komplexen mit NS+ AsF. Gleichung (1) zeigt exemplarisch eine Reaktion, die quantitativ verläuft.
AbstractBei Umsetzung der Titelsalze (I) [Darstellung von (Ic) bzw. (Ib) aus (Ia) bzw. (II); Charakterisierung der Nebenprodukte] mit Zn in flüssigem SO2 erhält man die 7n‐Radikale (IV), die mit 802C]; wieder zu (I) oxidiert werden können.
AbstractFor corrigendum see DOI:10.1002/anie.198500761
A large number of new thionitrosyl complexes should be obtained via a very generally applicable route: the reaction of cationic CO- or SO2-complexes with NS+ AsF. Equation (1) shows by way of example a reaction that takes place quantitatively.
The preparation of [Re(CO)5NSX]+AsF6 - (2a X = Cl, 2b X = Br) is possible (a) by metathesis from [Re(CO)5NSF]+AsF6 - with SiX4, (b) by insertion of the NS+-cation into the metal-halogenbond of Re(CO)5X and (c) by nucleophilic halide addition to the sulfur in the dicationic thionitrosyl complex [Re(CO)5NS]+ +.
AbstractDie Darstellung der Titelverbindung (II) wird beschrieben.
The preparation of cyclo-(CF3CN)(NSCl)2 (2) from CF3CN and (NSCl)3 is reported. Dechlorination of 2 by Zn in liquid SO2 is found to yield either CF3CN3S2 or mainly CF3CN2S2, depending on the reaction conditions. The structure of 2 was determined from single crystal data.
Das fehlende Glied in der Reihe der isovalenzelektronischen 10π—Systeme S4N und (RC)2N4S2 ist das Kation (RC)N4S3⊕, R CF3, im Salz 1. Diese Verbindung wurde unter speziellen Bedingungen aus (SNCl)3, CF3CN und SO2 synthetisiert. Das Kation ist nahezu planar.
AbstractThe complete manuscript of this communication appears in: Angew. Chem. Suppl. 1983, 945. DOI:10.1002/anie.198309450