Objective Excision repair cross-complementing gene-1(ERCC1) are key regulatory enzymes whose expression patterns are associated with overall survival(OS) in several malignancies.Their expression patterns and prognostic value in resected gastric adenocarcinoma(GAC) are not known and need to investigate.Methods A total of 109 patients who underwent resection for GAC in Liu′an People′s Hospital from January 2010 to June 2013 had tissue available for analysis.The primary objective was to assess for the differential expression of ERCC1 using by immunohistochemistry.The secondary objective was to assess for the association between OS and the expression of ERCC1.Results The median follow-up was 21.2 months,and the median OS was 28.8 months.Resected GAC exhibited differential expression of ERCC1(high expression,n=25(23%)).ERCC1 expression was not associated with OS(18.9 months vs.27.7 months,P=0.72).In a subset analysis of patients who received chemotherapy(n=73),high ERCC1 expression was associated with decreased OS(16.7 months vs.53.8 months,P=0.03).After controlling for known adverse pathologic features,high ERCC1 expression persisted as a negative prognostic factor in multivariate Cox regression analysis(HR=2.22,95% CI1.05-4.98,P<0.05).Conversely,in patients who underwent resection only(n=35),high ERCC1 expression demonstrated a trend toward improved OS(40.4 months vs.12.7 months,P=0.10).A positive prognostic influence also was present on multivariate analysis(HR=0.20,95% CI0.05-0.84,P=0.03).Conclusion Resected GAC exhibited differential expression of ERCC1.Among all patients,ERCC1 expression levels were not associated with OS.High ERCC1 tumor expression is associated with decreased OS in the patients who received chemotherapy but is associated with increased OS in those who underwent surgery alone.ERCC1 expression have prognostic value in resected gastric cancer,and further investigation is needed.

目的比较小切口胆囊切除术(MC)与传统开腹胆囊切除术(OC)治疗急性胆囊炎的临床疗效。方法将符合手术条件的80例急性胆囊炎患者,按照就诊先后顺序,随机分为A组和B组,每组40例,A组采用MC治疗,B组采用OC治疗,治疗过程中观察两组患者的平均手术时间、术中平均出血量、平均切口长度、平均住院时间及并发症等情况。结果两组患者在平均手术时间、术中平均出血量、平均切口长度、平均住院时间及并发症等方面比较差异均有统计学意义(P<0.05),A组患者的各项指标均低于B组患者。结论两种手术方法治疗急性胆囊炎均有效,小切口胆囊切除术(MC)的疗效优于传统开腹胆囊切除术(OC),具有手术时间短、术中出血量少、住院时间短、手术切口小、并发症低等优点,可在广大基层医院作为急性胆囊炎手术治疗的首选术式推广应用。

Objective In our hospital from 2007 to 2010,50 cases of tick-borne encephalitis patient clinical data retrospectively,discuss the disease is the leading cause of death.Method 50 cases of male patients in 41 cases,feimale 9cases,aged 17 to 60 years old.The average age of 32.5 years,all patients living in endemic areas.At least 1 tick bites.After the incubation period of typical clinical manifestations,combined with forest encephalitis immunofluorescence antibody positive,and related auxiliary examination results,with the exception of other central nervous system infectious disease after diagnosis.Results 50 patients,38 cases were cured,7 cases died,giving up treatment in 3 cases,left limb movement disorder,intelligence impairment,psychiatric symptoms and sequelae in 2 cases.Conclusion Forest encephalitis virus invasion of brain and brainstem after induced respiratory muscle paralysis,assisted mechanical ventilator patients can greatly reduce the mortality,and actively given antiviral,gamma globulin,prevention and treatment of cerebral edema,prevention of lung infection,maintaining water and electrolyte balance is also very important.Advance of forest encephalitis vaccine inoculation into the forest,be of great advantage for personnel

腺样囊性癌是生长缓慢但恶性度高的上皮性肿瘤,好发于腮腺、颌下腺、舌下腺、腭腺等小涎腺及皮肤等组织,其具有局部侵袭性强、远处转移率高、长期预后较差等典型生物学特征.目前,治疗腺样囊性癌主要是采用以手术为主,辅以术后化学治疗、放射治疗和基因分子治疗等综合治疗手段,能显著提高患者疗效及改善患者预后.我们近期诊断皮肤腺样囊性癌1例,现报道如下.

<正>现将我院自2007年1月至2010年9月收治的分别误诊为脑卒中及病毒性脑炎的神经梅毒2例报道如下。1病例资料例1:患者男性,47岁。主因左侧肢体偏瘫,偏身感觉障碍,中枢性面舌瘫,言语含糊2d,于2007年1月20日入院。患者在发病前有发热史。否认高血压及糖尿病病史。入院后查体,初步诊断为脑卒中,给予脑血管疾病二级预防治疗的同时进一步检查,行免疫全项示